Detalhe da pesquisa
1.
A Small Molecule Allele-selective Transcriptional Inhibitor of the MIF Immune Susceptibility Locus.
J Biol Chem
; : 107443, 2024 Jun 03.
Artigo
Inglês
| MEDLINE | ID: mdl-38838773
2.
Iguratimod, an allosteric inhibitor of macrophage migration inhibitory factor (MIF), prevents mortality and oxidative stress in a murine model of acetaminophen overdose.
Mol Med
; 30(1): 43, 2024 Mar 27.
Artigo
Inglês
| MEDLINE | ID: mdl-38539088
3.
A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase.
J Biol Chem
; 297(3): 101061, 2021 09.
Artigo
Inglês
| MEDLINE | ID: mdl-34384784
4.
Design, synthesis, in-vitro evaluation and molecular docking studies of novel indole derivatives as inhibitors of SIRT1 and SIRT2.
Bioorg Chem
; 92: 103281, 2019 11.
Artigo
Inglês
| MEDLINE | ID: mdl-31561106
5.
Plant MDL proteins synergize with the cytokine MIF at CXCR2 and CXCR4 receptors in human cells.
Sci Signal
; 16(812): eadg2621, 2023 11 21.
Artigo
Inglês
| MEDLINE | ID: mdl-37988455
6.
A Cysteine Variant at an Allosteric Site Alters MIF Dynamics and Biological Function in Homo- and Heterotrimeric Assemblies.
Front Mol Biosci
; 9: 783669, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-35252348
7.
SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases.
Front Pharmacol
; 11: 585821, 2020.
Artigo
Inglês
| MEDLINE | ID: mdl-33597872
8.
Rational discovery of a SOD1 tryptophan oxidation inhibitor with therapeutic potential for amyotrophic lateral sclerosis.
J Biomol Struct Dyn
; 37(15): 3936-3946, 2019 09.
Artigo
Inglês
| MEDLINE | ID: mdl-30286701
9.
Assessment of ligand binding at a site relevant to SOD1 oxidation and aggregation.
FEBS Lett
; 592(10): 1725-1737, 2018 05.
Artigo
Inglês
| MEDLINE | ID: mdl-29679384
10.
Bromodomain and extra-terminal (BET) family proteins: New therapeutic targets in major diseases.
J Biosci
; 41(2): 295-311, 2016 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-27240990
11.
A Novel Phenanthridionone Based Scaffold As a Potential Inhibitor of the BRD2 Bromodomain: Crystal Structure of the Complex.
PLoS One
; 11(5): e0156344, 2016.
Artigo
Inglês
| MEDLINE | ID: mdl-27243809