Detalhe da pesquisa
1.
A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis.
Nature
; 546(7658): 376-380, 2017 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28562588
2.
Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling.
PLoS Pathog
; 12(8): e1005737, 2016 08.
Artigo
Inglês
| MEDLINE | ID: mdl-27500641
3.
Comprehensive physicochemical, pharmacokinetic and activity profiling of anti-TB agents.
J Antimicrob Chemother
; 70(3): 857-67, 2015 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-25587994
4.
Perspective: Challenges and opportunities in TB drug discovery from phenotypic screening.
Bioorg Med Chem
; 23(16): 5087-97, 2015 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25577708
5.
A novel F(420) -dependent anti-oxidant mechanism protects Mycobacterium tuberculosis against oxidative stress and bactericidal agents.
Mol Microbiol
; 87(4): 744-55, 2013 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-23240649
6.
Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression.
PLoS Pathog
; 7(9): e1002264, 2011 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-21980288
7.
Drug discovery for parasitic diseases: powered by technology, enabled by pharmacology, informed by clinical science.
Trends Parasitol
; 39(4): 260-271, 2023 04.
Artigo
Inglês
| MEDLINE | ID: mdl-36803572
8.
Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections.
Science
; 380(6652): 1349-1356, 2023 06 30.
Artigo
Inglês
| MEDLINE | ID: mdl-37384702
9.
Vitamin B6 biosynthesis is essential for survival and virulence of Mycobacterium tuberculosis.
Mol Microbiol
; 78(4): 980-8, 2010 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-20815826
10.
A continuous fluorescence displacement assay for BioA: an enzyme involved in biotin biosynthesis.
Anal Biochem
; 416(1): 27-38, 2011 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21621502
11.
Opportunities and Challenges in Developing a Cryptosporidium Controlled Human Infection Model for Testing Antiparasitic Agents.
ACS Infect Dis
; 7(5): 959-968, 2021 05 14.
Artigo
Inglês
| MEDLINE | ID: mdl-33822577
12.
Use-case scenarios for an anti-Cryptosporidium therapeutic.
PLoS Negl Trop Dis
; 15(3): e0009057, 2021 03.
Artigo
Inglês
| MEDLINE | ID: mdl-33705395
13.
Benzoheterocyclic Oxime Carbamates Active against Mycobacterium tuberculosis: Synthesis, Structure-Activity Relationship, Metabolism, and Biology Triaging.
J Med Chem
; 64(13): 9444-9457, 2021 07 08.
Artigo
Inglês
| MEDLINE | ID: mdl-34138573
14.
Innovations in Addressing Pediatric Diarrhea in Low Resource Settings.
ACS Infect Dis
; 6(1): 14-24, 2020 01 10.
Artigo
Inglês
| MEDLINE | ID: mdl-31612701
15.
Setting Our Sights on Infectious Diseases.
ACS Infect Dis
; 6(1): 3-13, 2020 01 10.
Artigo
Inglês
| MEDLINE | ID: mdl-31808676
16.
Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates.
Infect Immun
; 76(6): 2333-40, 2008 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-18347040
17.
Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824.
Bioorg Med Chem Lett
; 18(7): 2256-62, 2008 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18358721
18.
Safe and effective treatments are needed for cryptosporidiosis, a truly neglected tropical disease.
BMJ Glob Health
; 8(8)2023 08.
Artigo
Inglês
| MEDLINE | ID: mdl-37541693
19.
Development of a Cytopathic Effect-Based Phenotypic Screening Assay against Cryptosporidium.
ACS Infect Dis
; 4(4): 635-645, 2018 04 13.
Artigo
Inglês
| MEDLINE | ID: mdl-29341586
20.
A monoclonal antibody that inhibits mycobacterial DNA gyrase by a novel mechanism.
Nucleic Acids Res
; 33(10): 3085-94, 2005.
Artigo
Inglês
| MEDLINE | ID: mdl-15930158