Detalhe da pesquisa
1.
Apalutamide Absorption, Metabolism, and Excretion in Healthy Men, and Enzyme Reaction in Human Hepatocytes.
Drug Metab Dispos
; 47(5): 453-464, 2019 05.
Artigo
Inglês
| MEDLINE | ID: mdl-30787101
2.
Comments to pharmacological and behavioral divergence of ketamine enantiomers by Jordi Bonaventura et al.
Mol Psychiatry
; 27(4): 1860-1862, 2022 04.
Artigo
Inglês
| MEDLINE | ID: mdl-35177823
3.
Dose- and Time-dependency of the Toxicity and Pharmacokinetic Profiles of Bedaquiline and Its N-desmethyl Metabolite in Dogs.
Toxicol Pathol
; 45(5): 663-675, 2017 07.
Artigo
Inglês
| MEDLINE | ID: mdl-28789609
4.
Absorption, metabolism, and excretion of oral ¹4C radiolabeled ibrutinib: an open-label, phase I, single-dose study in healthy men.
Drug Metab Dispos
; 43(2): 289-97, 2015 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-25488930
5.
Physiology-based IVIVE predictions of tramadol from in vitro metabolism data.
Pharm Res
; 32(1): 260-74, 2015 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-25048637
6.
A phase I, open-label, single-dose, mass balance study of 14C-labeled abiraterone acetate in healthy male subjects.
Xenobiotica
; 43(4): 379-89, 2013 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-23020788
7.
Pharmacokinetics, metabolism and excretion of 14C-monoethyl phthalate (MEP) and 14C-diethyl phthalate (DEP) after single oral and IV administration in the juvenile dog.
Xenobiotica
; 42(4): 389-97, 2012 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-22054055
8.
Prediction of Drug-Drug Interactions After Esketamine Intranasal Administration Using a Physiologically Based Pharmacokinetic Model.
Clin Pharmacokinet
; 61(8): 1115-1128, 2022 08.
Artigo
Inglês
| MEDLINE | ID: mdl-35579824
9.
Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity.
Mol Cancer Ther
; 20(12): 2317-2328, 2021 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34583982
10.
Absorption, metabolism, and excretion of darunavir, a new protease inhibitor, administered alone and with low-dose ritonavir in healthy subjects.
Drug Metab Dispos
; 37(4): 809-20, 2009 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-19131522
11.
Which human metabolites have we MIST? Retrospective analysis, practical aspects, and perspectives for metabolite identification and quantification in pharmaceutical development.
Chem Res Toxicol
; 22(2): 280-93, 2009 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-19183054
12.
Disposition, metabolism, and excretion of [14C]doripenem after a single 500-milligram intravenous infusion in healthy men.
Antimicrob Agents Chemother
; 52(10): 3478-83, 2008 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-18644951
13.
Absorption, metabolism, and excretion of paliperidone, a new monoaminergic antagonist, in humans.
Drug Metab Dispos
; 36(4): 769-79, 2008 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-18227146
14.
The ontogeny of drug metabolizing enzymes and transporters in the rat.
Reprod Toxicol
; 26(3-4): 220-30, 2008.
Artigo
Inglês
| MEDLINE | ID: mdl-18926897
15.
Strategies for Determining Correct Cytochrome P450 Contributions in Hepatic Clearance Predictions: In Vitro-In Vivo Extrapolation as Modelling Approach and Tramadol as Proof-of Concept Compound.
Eur J Drug Metab Pharmacokinet
; 42(3): 537-543, 2017 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-27317395
16.
Best practices for metabolite quantification in drug development: updated recommendation from the European Bioanalysis Forum.
Bioanalysis
; 8(12): 1297-305, 2016 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-27217058
17.
Synthesis, in vitro and in vivo small-animal SPECT evaluation of novel technetium labeled bile acid analogues to study (altered) hepatic transporter function.
Nucl Med Biol
; 43(10): 642-9, 2016 10.
Artigo
Inglês
| MEDLINE | ID: mdl-27513813
18.
Cell-based models to study hepatic drug metabolism and enzyme induction in humans.
Expert Opin Drug Metab Toxicol
; 1(1): 75-90, 2005 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-16922654
19.
Evaluation of the Pharmacokinetics and Renal Excretion of Simeprevir in Subjects with Renal Impairment.
Drugs R D
; 15(3): 261-70, 2015 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-26248593
20.
Physiologically Based Pharmacokinetic Predictions of Tramadol Exposure Throughout Pediatric Life: an Analysis of the Different Clearance Contributors with Emphasis on CYP2D6 Maturation.
AAPS J
; 17(6): 1376-87, 2015 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-26209290