Detalhe da pesquisa
1.
Laquinimod arrests experimental autoimmune encephalomyelitis by activating the aryl hydrocarbon receptor.
Proc Natl Acad Sci U S A
; 113(41): E6145-E6152, 2016 10 11.
Artigo
Inglês
| MEDLINE | ID: mdl-27671624
2.
Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening.
J Comput Aided Mol Des
; 24(12): 971-91, 2010 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-20976528
3.
VRX-03011, a novel 5-HT4 agonist, enhances memory and hippocampal acetylcholine efflux.
Neuropharmacology
; 53(4): 563-73, 2007 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-17692343
4.
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
J Med Chem
; 49(11): 3116-35, 2006 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-16722631
5.
PREDICT modeling and in-silico screening for G-protein coupled receptors.
Proteins
; 57(1): 51-86, 2004 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-15326594
6.
Modeling the 3D structure of GPCRs: advances and application to drug discovery.
Curr Opin Drug Discov Devel
; 6(3): 353-61, 2003 May.
Artigo
Inglês
| MEDLINE | ID: mdl-12833668
7.
Benzofuran Derivatives as Potent, Orally Active S1P1 Receptor Agonists: A Preclinical Lead Molecule for MS.
ACS Med Chem Lett
; 2(2): 97-101, 2011 Feb 10.
Artigo
Inglês
| MEDLINE | ID: mdl-24900286
8.
Discovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1).
ACS Med Chem Lett
; 2(2): 102-6, 2011 Feb 10.
Artigo
Inglês
| MEDLINE | ID: mdl-24900287
9.
G Protein-Coupled Receptors: target-based in silico screening.
Curr Pharm Des
; 15(35): 4049-68, 2009.
Artigo
Inglês
| MEDLINE | ID: mdl-20028321
10.
SeleX-CS: a new consensus scoring algorithm for hit discovery and lead optimization.
J Chem Inf Model
; 49(3): 623-33, 2009 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-19231809
11.
G protein-coupled receptors: in silico drug discovery in 3D.
Proc Natl Acad Sci U S A
; 101(31): 11304-9, 2004 Aug 03.
Artigo
Inglês
| MEDLINE | ID: mdl-15277683