Detalhe da pesquisa
1.
In Vivo Metabolism of Aristolochic Acid I and II in Rats Is Influenced by Their Coexposure.
Chem Res Toxicol
; 33(11): 2804-2818, 2020 11 16.
Artigo
Inglês
| MEDLINE | ID: mdl-32894017
2.
Heme: emergent roles of heme in signal transduction, functional regulation and as catalytic centres.
Chem Soc Rev
; 48(24): 5624-5657, 2019 Dec 09.
Artigo
Inglês
| MEDLINE | ID: mdl-31748766
3.
Identification of Human Enzymes Oxidizing the Anti-Thyroid-Cancer Drug Vandetanib and Explanation of the High Efficiency of Cytochrome P450 3A4 in its Oxidation.
Int J Mol Sci
; 20(14)2019 Jul 10.
Artigo
Inglês
| MEDLINE | ID: mdl-31295928
4.
Coordination and redox state-dependent structural changes of the heme-based oxygen sensor AfGcHK associated with intraprotein signal transduction.
J Biol Chem
; 292(51): 20921-20935, 2017 12 22.
Artigo
Inglês
| MEDLINE | ID: mdl-29092908
5.
Highly conserved nucleotide phosphatase essential for membrane lipid homeostasis in Streptococcus pneumoniae.
Mol Microbiol
; 101(1): 12-26, 2016 07.
Artigo
Inglês
| MEDLINE | ID: mdl-26691161
6.
Structural characterization of the heme-based oxygen sensor, AfGcHK, its interactions with the cognate response regulator, and their combined mechanism of action in a bacterial two-component signaling system.
Proteins
; 84(10): 1375-89, 2016 10.
Artigo
Inglês
| MEDLINE | ID: mdl-27273553
7.
Membrane-Anchored Cytochrome P450 1A2-Cytochrome b5 Complex Features an X-Shaped Contact between Antiparallel Transmembrane Helices.
Chem Res Toxicol
; 29(4): 626-36, 2016 Apr 18.
Artigo
Inglês
| MEDLINE | ID: mdl-26918755
8.
Lipid molecules can induce an opening of membrane-facing tunnels in cytochrome P450 1A2.
Phys Chem Chem Phys
; 18(44): 30344-30356, 2016 Nov 09.
Artigo
Inglês
| MEDLINE | ID: mdl-27722524
9.
Active Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1.
Int J Mol Sci
; 17(2): 213, 2016 Feb 05.
Artigo
Inglês
| MEDLINE | ID: mdl-26861298
10.
Ferrous and ferric state of cytochromes P450 in intact Escherichia coli cells: a possible role of cytochrome P450-flavodoxin interactions.
Neuro Endocrinol Lett
; 36 Suppl 1: 29-37, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-26757119
11.
A Mechanism of O-Demethylation of Aristolochic Acid I by Cytochromes P450 and Their Contributions to This Reaction in Human and Rat Livers: Experimental and Theoretical Approaches.
Int J Mol Sci
; 16(11): 27561-75, 2015 Nov 18.
Artigo
Inglês
| MEDLINE | ID: mdl-26593908
12.
Flexible docking-based molecular dynamics/steered molecular dynamics calculations of protein-protein contacts in a complex of cytochrome P450 1A2 with cytochrome b5.
Biochemistry
; 53(42): 6695-705, 2014 Oct 28.
Artigo
Inglês
| MEDLINE | ID: mdl-25313797
13.
Mechanisms of enzyme-catalyzed reduction of two carcinogenic nitro-aromatics, 3-nitrobenzanthrone and aristolochic acid I: Experimental and theoretical approaches.
Int J Mol Sci
; 15(6): 10271-95, 2014 Jun 10.
Artigo
Inglês
| MEDLINE | ID: mdl-24918288
14.
Induced expression of cytochrome P450 1A and NAD(P)H:quinone oxidoreductase determined at mRNA, protein, and enzyme activity levels in rats exposed to the carcinogenic azo dye 1-phenylazo-2-naphthol (Sudan I).
Chem Res Toxicol
; 26(2): 290-9, 2013 Feb 18.
Artigo
Inglês
| MEDLINE | ID: mdl-23289503
15.
Case report: A rare variant m.4135T>C in the MT-ND1 gene leads to Leber hereditary optic neuropathy and altered respiratory chain supercomplexes.
Front Genet
; 14: 1182288, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-37274791
16.
Cytochrome b5 increases cytochrome P450 3A4-mediated activation of anticancer drug ellipticine to 13-hydroxyellipticine whose covalent binding to DNA is elevated by sulfotransferases and N,O-acetyltransferases.
Chem Res Toxicol
; 25(5): 1075-85, 2012 May 21.
Artigo
Inglês
| MEDLINE | ID: mdl-22390216
17.
Theoretical investigation of differences in nitroreduction of aristolochic acid I by cytochromes P450 1A1, 1A2 and 1B1.
Neuro Endocrinol Lett
; 33 Suppl 3: 25-32, 2012.
Artigo
Inglês
| MEDLINE | ID: mdl-23353840
18.
Mapping of interaction between cytochrome P450 2B4 and cytochrome b5: the first evidence of two mutual orientations.
Neuro Endocrinol Lett
; 33 Suppl 3: 41-7, 2012.
Artigo
Inglês
| MEDLINE | ID: mdl-23353842
19.
Comparison of activation of aristolochic acid I and II with NADPH:quinone oxidoreductase, sulphotransferases and N-acetyltranferases.
Neuro Endocrinol Lett
; 32 Suppl 1: 57-70, 2011.
Artigo
Inglês
| MEDLINE | ID: mdl-22167209
20.
Homozygous missense mutation in UQCRC2 associated with severe encephalomyopathy, mitochondrial complex III assembly defect and activation of mitochondrial protein quality control.
Biochim Biophys Acta Mol Basis Dis
; 1867(8): 166147, 2021 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33865955