Detalhe da pesquisa
1.
Compound Activity Prediction with Dose-Dependent Transcriptomic Profiles and Deep Learning.
J Chem Inf Model
; 64(7): 2695-2704, 2024 Apr 08.
Artigo
Inglês
| MEDLINE | ID: mdl-38293736
2.
On the Choice of Active Site Sequences for Kinase-Ligand Affinity Prediction.
J Chem Inf Model
; 62(18): 4295-4299, 2022 09 26.
Artigo
Inglês
| MEDLINE | ID: mdl-36098536
3.
Collaborative Profile-QSAR: A Natural Platform for Building Collaborative Models among Competing Companies.
J Chem Inf Model
; 61(4): 1603-1616, 2021 04 26.
Artigo
Inglês
| MEDLINE | ID: mdl-33844519
4.
Biased Diversity for Effective Virtual Screening.
J Chem Inf Model
; 60(9): 4116-4119, 2020 09 28.
Artigo
Inglês
| MEDLINE | ID: mdl-32026691
5.
All-Assay-Max2 pQSAR: Activity Predictions as Accurate as Four-Concentration IC50s for 8558 Novartis Assays.
J Chem Inf Model
; 59(10): 4450-4459, 2019 10 28.
Artigo
Inglês
| MEDLINE | ID: mdl-31518124
6.
Physiologically Based Pharmacokinetic Modeling in Lead Optimization. 2. Rational Bioavailability Design by Global Sensitivity Analysis To Identify Properties Affecting Bioavailability.
Mol Pharm
; 15(3): 831-839, 2018 03 05.
Artigo
Inglês
| MEDLINE | ID: mdl-29337562
7.
Physiologically Based Pharmacokinetic Modeling in Lead Optimization. 1. Evaluation and Adaptation of GastroPlus To Predict Bioavailability of Medchem Series.
Mol Pharm
; 15(3): 821-830, 2018 03 05.
Artigo
Inglês
| MEDLINE | ID: mdl-29337578
8.
Profile-QSAR 2.0: Kinase Virtual Screening Accuracy Comparable to Four-Concentration IC50s for Realistically Novel Compounds.
J Chem Inf Model
; 57(8): 2077-2088, 2017 08 28.
Artigo
Inglês
| MEDLINE | ID: mdl-28651433
9.
Traumatic injury causes selective degeneration and TDP-43 mislocalization in human iPSC-derived C9orf72-associated ALS/FTD motor neurons.
bioRxiv
; 2024 Mar 26.
Artigo
Inglês
| MEDLINE | ID: mdl-38585915
10.
Enhancing the Small-Scale Screenable Biological Space beyond Known Chemogenomics Libraries with Gray Chemical MatterâCompounds with Novel Mechanisms from High-Throughput Screening Profiles.
ACS Chem Biol
; 19(4): 938-952, 2024 Apr 19.
Artigo
Inglês
| MEDLINE | ID: mdl-38565185
11.
Polyurethane Culture Substrates Enable Long-Term Neuron Monoculture in a Human in vitro Model of Neurotrauma.
Neurotrauma Rep
; 4(1): 682-692, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-37908320
12.
Abyssal hydrothermal springs-Cryptic incubators for brooding octopus.
Sci Adv
; 9(34): eadg3247, 2023 08 25.
Artigo
Inglês
| MEDLINE | ID: mdl-37611094
13.
Removal of trichloroethene from thin clay lenses by electrical resistance heating: Laboratory experiments and the effects of gas saturation.
J Contam Hydrol
; 243: 103892, 2021 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34634516
14.
MAIP: a web service for predicting blood-stage malaria inhibitors.
J Cheminform
; 13(1): 13, 2021 Feb 22.
Artigo
Inglês
| MEDLINE | ID: mdl-33618772
15.
TETs compete with DNMT3 activity in pluripotent cells at thousands of methylated somatic enhancers.
Nat Genet
; 52(8): 819-827, 2020 08.
Artigo
Inglês
| MEDLINE | ID: mdl-32514123
16.
Dissecting the Functional Consequences of De Novo DNA Methylation Dynamics in Human Motor Neuron Differentiation and Physiology.
Cell Stem Cell
; 22(4): 559-574.e9, 2018 04 05.
Artigo
Inglês
| MEDLINE | ID: mdl-29551301
17.
Blockade of orexin receptors attenuates the cardiovascular response to air-jet stress in spontaneously hypertensive rats.
Auton Neurosci
; 201: 8-16, 2016 12.
Artigo
Inglês
| MEDLINE | ID: mdl-27591948
18.
Target-biased scoring approaches and expert systems in structure-based virtual screening.
Curr Opin Chem Biol
; 8(4): 359-64, 2004 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-15288244
19.
Chronic heart failure alters orexin and melanin concentrating hormone but not corticotrophin releasing hormone-related gene expression in the brain of male Lewis rats.
Neuropeptides
; 52: 67-72, 2015 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-26111703
20.
Exploiting structure-activity relationships in docking.
J Chem Inf Model
; 48(4): 817-30, 2008 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-18399649