Detalhe da pesquisa
1.
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.
Cell
; 149(3): 656-70, 2012 Apr 27.
Artigo
Inglês
| MEDLINE | ID: mdl-22541435
2.
Telomere dysfunction induces metabolic and mitochondrial compromise.
Nature
; 470(7334): 359-65, 2011 Feb 17.
Artigo
Inglês
| MEDLINE | ID: mdl-21307849
3.
Discovery of KIN-3248, An Irreversible, Next Generation FGFR Inhibitor for the Treatment of Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations.
J Med Chem
; 67(3): 1734-1746, 2024 Feb 08.
Artigo
Inglês
| MEDLINE | ID: mdl-38267212
4.
The Discovery of Exarafenib (KIN-2787): Overcoming the Challenges of Pan-RAF Kinase Inhibition.
J Med Chem
; 67(3): 1747-1757, 2024 Feb 08.
Artigo
Inglês
| MEDLINE | ID: mdl-38230963
5.
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers.
Nature
; 447(7147): 966-71, 2007 Jun 21.
Artigo
Inglês
| MEDLINE | ID: mdl-17515920
6.
BRCA1 E1644X: a deleterious mutation in an African American individual with early onset breast cancer.
Breast Cancer Res Treat
; 113(2): 393-5, 2009 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-18311584
7.
Overview of genetically engineered mouse models of colorectal carcinoma to enable translational biology and drug development.
Curr Protoc Pharmacol
; 65: 14.29.1-10, 2014 Jun 16.
Artigo
Inglês
| MEDLINE | ID: mdl-24934606
8.
Cross-species analysis of genetically engineered mouse models of MAPK-driven colorectal cancer identifies hallmarks of the human disease.
Dis Model Mech
; 7(6): 613-23, 2014 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-24742783
9.
Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer.
Cancer Lett
; 347(2): 204-11, 2014 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24576621
10.
Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR.
Sci Signal
; 7(351): ra107, 2014 Nov 11.
Artigo
Inglês
| MEDLINE | ID: mdl-25389372
11.
Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer.
Clin Cancer Res
; 19(10): 2688-98, 2013 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-23549875
12.
Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation.
Clin Cancer Res
; 19(11): 2929-40, 2013 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23403635
13.
Identification of a HMGA2-EFCAB6 gene rearrangement following next-generation sequencing in a patient with a t(12;22)(q14.3;q13.2) and JAK2V617F-positive myeloproliferative neoplasm.
Cancer Genet
; 205(6): 295-303, 2012 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-22749035
14.
The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer.
PLoS One
; 6(9): e25132, 2011.
Artigo
Inglês
| MEDLINE | ID: mdl-21966435
15.
BRCA1 IVS2-2delA: a deleterious mutation in a family of Asian descent.
Cancer Genet Cytogenet
; 150(2): 173-5, 2004 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-15066328
16.
Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types.
Cancer Res
; 67(22): 10736-43, 2007 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18006816
17.
Human peripheral CD2-/lo T cells: an extrathymic population of early differentiated, developing T cells.
Int Immunol
; 17(9): 1213-25, 2005 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-16027135
18.
High-resolution genomic profiles of human lung cancer.
Proc Natl Acad Sci U S A
; 102(27): 9625-30, 2005 Jul 05.
Artigo
Inglês
| MEDLINE | ID: mdl-15983384
19.
A genetic screen for candidate tumor suppressors identifies REST.
Cell
; 121(6): 837-48, 2005 Jun 17.
Artigo
Inglês
| MEDLINE | ID: mdl-15960972
20.
The BCSC-1 locus at chromosome 11q23-q24 is a candidate tumor suppressor gene.
Proc Natl Acad Sci U S A
; 100(20): 11517-22, 2003 Sep 30.
Artigo
Inglês
| MEDLINE | ID: mdl-14504409