Detalhe da pesquisa
1.
Comparative analytical performance of multiple plasma Aß42 and Aß40 assays and their ability to predict positron emission tomography amyloid positivity.
Alzheimers Dement
; 2022 Jul 12.
Artigo
Inglês
| MEDLINE | ID: mdl-35820077
2.
Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade.
Proc Natl Acad Sci U S A
; 105(25): 8754-9, 2008 Jun 24.
Artigo
Inglês
| MEDLINE | ID: mdl-18559859
3.
Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
J Pharmacol Exp Ther
; 331(2): 598-608, 2009 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-19671883
4.
(S)-N-(5-Chlorothiophene-2-sulfonyl)-beta,beta-diethylalaninol a Notch-1-sparing gamma-secretase inhibitor.
Bioorg Med Chem Lett
; 19(3): 926-9, 2009 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19097890
5.
Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide gamma-secretase inhibitors.
Bioorg Med Chem
; 17(13): 4708-17, 2009 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19443228
6.
Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease.
J Neurosci
; 25(39): 8898-902, 2005 Sep 28.
Artigo
Inglês
| MEDLINE | ID: mdl-16192379
7.
Reference measurement procedures for Alzheimer's disease cerebrospinal fluid biomarkers: definitions and approaches with focus on amyloid ß42.
Biomark Med
; 6(4): 409-17, 2012 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-22917143
8.
Purinergic receptor-mediated morphological changes in microglia are transient and independent from inflammatory cytokine release.
Eur J Pharmacol
; 643(2-3): 202-10, 2010 Sep 25.
Artigo
Inglês
| MEDLINE | ID: mdl-20621081
9.
The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease.
Mol Cell Neurosci
; 34(4): 621-8, 2007 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-17336088