RESUMO
Analysis of the microcirculation indices in 246 patients, suffering diabetic foot syndrome (DFS), was presented. For a neuropathic form of DFS characteristic is lowering of the arterioles tone and enhancement of the blood volume in them, witnessed by raising of constant component of the blood flow. General worsening of perfusion is caused by lowering of endothelial secretion activation, and as well as neurogenic and myogenic control mechanisms. Occurrence of neurogenic regulation disorder is witnessed by the neurogenic oscillations lowering, the neurogenic and myogenic tone raising. In ischemic form of DFS there was noted the perfusion disorder, connected with reduction of the arterial inflow volume. The indices changes witness the disorder of sympathetic regulation of microcirculation and arteriole-venular reactions. The change of the perfusion indices, caused by a congestion processes in arterioles and venules, is characteristic for the mixed form of DFS. The perfusion control mechanisms was noted, as a consequence of the endothelial secretion lowering and the neurogenic and myogenic mechanisms activation of a control. The neurogenic and myogenic tone raising occurs depending on the sympathetic component activity, causing the arterioles diameter reduction.
Assuntos
Diabetes Mellitus Tipo 2/complicações , Diabetes Mellitus Tipo 2/fisiopatologia , Pé Diabético/complicações , Pé Diabético/fisiopatologia , Microcirculação/fisiologia , Idoso , Arteríolas/patologia , Arteríolas/fisiopatologia , Velocidade do Fluxo Sanguíneo/fisiologia , Estudos de Casos e Controles , Interpretação Estatística de Dados , Diabetes Mellitus Tipo 2/patologia , Pé Diabético/patologia , Endotélio Vascular/fisiologia , Feminino , Pé/irrigação sanguínea , Pé/inervação , Humanos , Fluxometria por Laser-Doppler , Masculino , Pessoa de Meia-Idade , Contração Muscular/fisiologia , Sistema Nervoso Simpático/fisiologiaAssuntos
Antibacterianos/uso terapêutico , Bactérias/efeitos dos fármacos , Infecções Bacterianas/tratamento farmacológico , Carbapenêmicos/uso terapêutico , Sepse/tratamento farmacológico , Bactérias/crescimento & desenvolvimento , Bactérias/isolamento & purificação , Infecções Bacterianas/diagnóstico , Infecções Bacterianas/microbiologia , Técnicas de Tipagem Bacteriana , Coleta de Amostras Sanguíneas/normas , Farmacorresistência Bacteriana , Humanos , Testes de Sensibilidade Microbiana , Sepse/diagnóstico , Sepse/microbiologiaRESUMO
There were examined 226 patients, in whom sepsis had occurred as a consequence of purulent-inflammatory diseases of soft tissues. The discrete plasmapheresis application in complex of intensive therapy had promoted the rapidest elimination of homeostasis disorders in the survived patients, but the influence on the lethality level was not revealed.
Assuntos
Plasmaferese/métodos , Sepse/terapia , Terapia Combinada , Medicina Baseada em Evidências , Feminino , Humanos , Masculino , Sepse/complicações , Sepse/diagnóstico , Sepse/mortalidade , Índice de Gravidade de Doença , Choque Séptico/diagnóstico , Choque Séptico/etiologia , Choque Séptico/mortalidade , Choque Séptico/terapia , Análise de Sobrevida , Resultado do TratamentoRESUMO
Possibilities of timely diagnosis of sepsis were discussed. Informativity of its clinical symptoms, laboratory and instrumental data was studied. Diagnostic criteria were formulated, the programme of complex diagnosis of sepsis was suggested.
Assuntos
Complicações Pós-Operatórias , Sepse/diagnóstico , Sepse/etiologia , Algoritmos , Diagnóstico Diferencial , Humanos , Leucocitose/diagnósticoRESUMO
A new method for measuring serum and tissue antioxidative activity is based on a relationship between accumulation of lipid peroxidation (LPO) products in incubation medium and the amount of the substrate during LPO activation. The ratio of malonic dialdehyde accumulation during LPO activation in two samples of different volumes is proposed as an index of antioxidative activity.