Detalhe da pesquisa
1.
Clinical Trial of the Anti-PD-L1 Antibody BMS-936559 in HIV-1 Infected Participants on Suppressive Antiretroviral Therapy.
J Infect Dis
; 215(11): 1725-1733, 2017 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28431010
2.
JNJ-7184, a Respiratory Syncytial Virus inhibitor targeting the connector domain of the viral polymerase.
Antiviral Res
; : 105907, 2024 May 19.
Artigo
Inglês
| MEDLINE | ID: mdl-38772503
3.
A novel inhibitor-binding site on the HIV-1 capsid N-terminal domain leads to improved crystallization via compound-mediated dimerization.
Acta Crystallogr D Biol Crystallogr
; 69(Pt 6): 1115-23, 2013 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-23695256
4.
Discovery of novel small-molecule HIV-1 replication inhibitors that stabilize capsid complexes.
Antimicrob Agents Chemother
; 57(10): 4622-31, 2013 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-23817385
5.
Distinct effects of two HIV-1 capsid assembly inhibitor families that bind the same site within the N-terminal domain of the viral CA protein.
J Virol
; 86(12): 6643-55, 2012 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-22496222
6.
Inhibition of HIV-1 capsid assembly: optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole scaffold.
Bioorg Med Chem Lett
; 22(24): 7512-7, 2012 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-23122820
7.
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19.
Nat Commun
; 12(1): 6055, 2021 10 18.
Artigo
Inglês
| MEDLINE | ID: mdl-34663813
8.
An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.
Science
; 374(6575): 1586-1593, 2021 Dec 24.
Artigo
Inglês
| MEDLINE | ID: mdl-34726479
9.
Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential Treatment of COVID-19.
bioRxiv
; 2021 Feb 12.
Artigo
Inglês
| MEDLINE | ID: mdl-32935104
10.
Modified Alphavirus-Vesiculovirus Hybrid Vaccine Vectors for Homologous Prime-Boost Immunotherapy of Chronic Hepatitis B.
Vaccines (Basel)
; 8(2)2020 Jun 05.
Artigo
Inglês
| MEDLINE | ID: mdl-32517032
11.
Blockade of the PD-1 axis alone is not sufficient to activate HIV-1 virion production from CD4+ T cells of individuals on suppressive ART.
PLoS One
; 14(1): e0211112, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-30682108
12.
Virus-like Vesicles Expressing Multiple Antigens for Immunotherapy of Chronic Hepatitis B.
iScience
; 21: 391-402, 2019 Nov 22.
Artigo
Inglês
| MEDLINE | ID: mdl-31704650
13.
Safety and efficacy of anti-PD-L1 therapy in the woodchuck model of HBV infection.
PLoS One
; 13(2): e0190058, 2018.
Artigo
Inglês
| MEDLINE | ID: mdl-29444087
14.
Polyadenylation-dependent screening assay for respiratory syncytial virus RNA transcriptase activity and identification of an inhibitor.
Nucleic Acids Res
; 32(16): 4758-67, 2004.
Artigo
Inglês
| MEDLINE | ID: mdl-15356293
15.
Aligning Potency and Pharmacokinetic Properties for Pyridine-Based NCINIs.
ACS Med Chem Lett
; 7(8): 797-801, 2016 Aug 11.
Artigo
Inglês
| MEDLINE | ID: mdl-27563405
16.
Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV.
ACS Med Chem Lett
; 5(6): 711-6, 2014 Jun 12.
Artigo
Inglês
| MEDLINE | ID: mdl-24944749
17.
Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1.
ACS Med Chem Lett
; 5(4): 422-7, 2014 Apr 10.
Artigo
Inglês
| MEDLINE | ID: mdl-24900852
18.
Discovery and structural characterization of a new inhibitor series of HIV-1 nucleocapsid function: NMR solution structure determination of a ternary complex involving a 2:1 inhibitor/NC stoichiometry.
J Mol Biol
; 425(11): 1982-1998, 2013 Jun 12.
Artigo
Inglês
| MEDLINE | ID: mdl-23485336
19.
Novel inhibitor binding site discovery on HIV-1 capsid N-terminal domain by NMR and X-ray crystallography.
ACS Chem Biol
; 8(5): 1074-82, 2013 May 17.
Artigo
Inglês
| MEDLINE | ID: mdl-23496828
20.
Monitoring binding of HIV-1 capsid assembly inhibitors using (19)F ligand-and (15)N protein-based NMR and X-ray crystallography: early hit validation of a benzodiazepine series.
ChemMedChem
; 8(3): 405-14, 2013 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-23401268