Detalhe da pesquisa
1.
Structural Insights into the Process of GPCR-G Protein Complex Formation.
Cell
; 177(5): 1243-1251.e12, 2019 05 16.
Artigo
Inglês
| MEDLINE | ID: mdl-31080070
2.
Allosteric modulation and G-protein selectivity of the Ca2+-sensing receptor.
Nature
; 626(8001): 1141-1148, 2024 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-38326620
3.
G-protein activation by a metabotropic glutamate receptor.
Nature
; 595(7867): 450-454, 2021 07.
Artigo
Inglês
| MEDLINE | ID: mdl-34194039
4.
Asymmetric activation of the calcium-sensing receptor homodimer.
Nature
; 595(7867): 455-459, 2021 07.
Artigo
Inglês
| MEDLINE | ID: mdl-34194040
5.
Structures of metabotropic GABAB receptor.
Nature
; 584(7820): 310-314, 2020 08.
Artigo
Inglês
| MEDLINE | ID: mdl-32580208
6.
Author Correction: Structural insights into the activation of metabotropic glutamate receptors.
Nature
; 567(7747): E10, 2019 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-30814739
7.
Structural insights into the activation of metabotropic glutamate receptors.
Nature
; 566(7742): 79-84, 2019 02.
Artigo
Inglês
| MEDLINE | ID: mdl-30675062
8.
Delineation of molecular determinants for FR900359 inhibition of Gq/11 unlocks inhibition of Gαs.
J Biol Chem
; 295(40): 13850-13861, 2020 10 02.
Artigo
Inglês
| MEDLINE | ID: mdl-32753482
9.
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist.
Nature
; 485(7398): 321-6, 2012 Mar 21.
Artigo
Inglês
| MEDLINE | ID: mdl-22437502
10.
Crystal structure of the ß2 adrenergic receptor-Gs protein complex.
Nature
; 477(7366): 549-55, 2011 Jul 19.
Artigo
Inglês
| MEDLINE | ID: mdl-21772288
11.
mGluR5: exploration of orthosteric and allosteric ligand binding pockets and their applications to drug discovery.
Neurochem Res
; 39(10): 1862-75, 2014 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-24493625
12.
Pharmacological characterization and modeling of the binding sites of novel 1,3-bis(pyridinylethynyl)benzenes as metabotropic glutamate receptor 5-selective negative allosteric modulators.
Mol Pharmacol
; 82(5): 929-37, 2012 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-22899869
13.
Delineation of the GPR15 receptor-mediated Gα protein signalling profile in recombinant mammalian cells.
Basic Clin Pharmacol Toxicol
; 131(2): 104-113, 2022 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-35510660
14.
Exploration of SAR features by modifications of thiazoleacetic acids as CRTH2 antagonists.
Bioorg Med Chem Lett
; 20(5): 1638-41, 2010 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20137942
15.
Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 2.
Bioorg Med Chem Lett
; 20(3): 1181-5, 2010 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20022749
16.
Dissecting the roles of GRK2 and GRK3 in µ-opioid receptor internalization and ß-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells.
Sci Rep
; 10(1): 17395, 2020 10 15.
Artigo
Inglês
| MEDLINE | ID: mdl-33060647
17.
Structure-activity relationships for negative allosteric mGluR5 modulators.
ChemMedChem
; 7(3): 440-51, 2012 Mar 05.
Artigo
Inglês
| MEDLINE | ID: mdl-22267204