Detalhe da pesquisa
1.
Negative allosteric modulation of the glucagon receptor by RAMP2.
Cell
; 186(7): 1465-1477.e18, 2023 03 30.
Artigo
Inglês
| MEDLINE | ID: mdl-37001505
2.
Glepaglutide, a novel glucagon-like peptide-2 agonist, has anti-inflammatory and mucosal regenerative effects in an experimental model of inflammatory bowel disease in rats.
BMC Gastroenterol
; 23(1): 79, 2023 Mar 21.
Artigo
Inglês
| MEDLINE | ID: mdl-36944922
3.
Glycine: a long-sought novel ligand for GPR158.
Trends Pharmacol Sci
; 44(8): 489-491, 2023 08.
Artigo
Inglês
| MEDLINE | ID: mdl-37321907
4.
A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity.
Bioorg Med Chem
; 18(16): 6089-98, 2010 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20638290
5.
Structural insights into differences in G protein activation by family A and family B GPCRs.
Science
; 369(6503)2020 07 31.
Artigo
Inglês
| MEDLINE | ID: mdl-32732395
6.
Probing the Existence of a Metastable Binding Site at the ß2-Adrenergic Receptor with Homobivalent Bitopic Ligands.
J Med Chem
; 62(17): 7806-7839, 2019 09 12.
Artigo
Inglês
| MEDLINE | ID: mdl-31298548
7.
Gs protein peptidomimetics as allosteric modulators of the ß2-adrenergic receptor.
RSC Adv
; 8(4): 2219-2228, 2018 Jan 05.
Artigo
Inglês
| MEDLINE | ID: mdl-35542596
8.
Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation.
Respir Res
; 8: 16, 2007 Feb 28.
Artigo
Inglês
| MEDLINE | ID: mdl-17328802
9.
Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits.
J Med Chem
; 49(23): 6638-41, 2006 Nov 16.
Artigo
Inglês
| MEDLINE | ID: mdl-17154491
10.
The metabotropic glutamate receptor 4 is internalized and desensitized upon protein kinase C activation.
Br J Pharmacol
; 148(3): 279-90, 2006 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-16582932
11.
Molecular pharmacology and therapeutic prospects of metabotropic glutamate receptor allosteric modulators.
Basic Clin Pharmacol Toxicol
; 97(4): 202-13, 2005 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-16176554
12.
A cAMP Biosensor-Based High-Throughput Screening Assay for Identification of Gs-Coupled GPCR Ligands and Phosphodiesterase Inhibitors.
J Biomol Screen
; 20(7): 849-57, 2015 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-25851033
13.
Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP.
Br J Pharmacol
; 138(6): 1026-30, 2003 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-12684257
14.
Real-time trafficking and signaling of the glucagon-like peptide-1 receptor.
Mol Cell Endocrinol
; 382(2): 938-49, 2014 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-24275181
15.
cAMP biosensors applied in molecular pharmacological studies of G protein-coupled receptors.
Methods Enzymol
; 522: 191-207, 2013.
Artigo
Inglês
| MEDLINE | ID: mdl-23374187
16.
The C-terminal tail of CRTH2 is a key molecular determinant that constrains Galphai and downstream signaling cascade activation.
J Biol Chem
; 284(2): 1324-36, 2009 Jan 09.
Artigo
Inglês
| MEDLINE | ID: mdl-19010788
17.
On the mechanism of interaction of potent surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2.
Mol Pharmacol
; 69(4): 1441-53, 2006 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-16418339
18.
Identification of indole derivatives exclusively interfering with a G protein-independent signaling pathway of the prostaglandin D2 receptor CRTH2.
Mol Pharmacol
; 68(2): 393-402, 2005 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-15870392