Scalable laser-based underwater wireless optical communication solution between autonomous underwater vehicle fleets.

The development of multiple autonomous underwater vehicles (AUVs) has revolutionized the traditional reliance on a single, costly AUV for conducting underwater surveys. This shift has garnered increasing interest among marine researchers. Communication between AUV fleets is an urgent concern due to the data rate limitation of underwater acoustic communication. Laser-based underwater wireless optical communication (UWOC) is a potential solution once the link-establishing requirement between AUVs can be met. Due to the limited coverage area of the laser beam, the previous pointing, acquisition, and tracking (PAT) method is to quickly adjust the beam direction and search for the target according to the set scanning path. In response to these challenges, we propose a scalable laser-based link establishment method that combines the maneuvering of the AUV, the acoustic positioning, and the control of the optical system. Our proposed approach has consistently outperformed the existing PAT method in simulated environments, effectively establishing laser links. Importantly, we have successfully implemented our approach in machine experiments, confirming its practical applicability.

Second-Generation AUTACs for Targeted Autophagic Degradation.

Targeted protein degradation via the ubiquitin-proteasome system has emerged as one of the most promising drug discovery modalities. Autophagy, another intracellular degradation system, can target a wide range of nonproteinous substrates as well as proteins, but its application to targeted degradation is still in its infancy. Our previous work revealed a relationship between guanine modification of cysteine residues on intracellular proteins and selective autophagy, resulting in the first autophagy-based degraders, autophagy-targeted chimeras (AUTACs). Based on the research background, all the reported AUTACs compounds contain cysteine as a substructure. Here, we examine the importance of this substructure by conducting SAR studies and report significant improvements in the degrader's activity by replacing cysteine with other moieties. Several derivatives showed sub-µM range degrading activity, demonstrating the increased practical value of AUTACs.