Pesquisa | Secretaria de Estado da Saúde

1.

Structural basis of kainate subtype glutamate receptor desensitization.

Meyerson, Joel R; Chittori, Sagar; Merk, Alan; Rao, Prashant; Han, Tae Hee; Serpe, Mihaela; Mayer, Mark L; Subramaniam, Sriram.

Nature ; 537(7621): 567-571, 2016 Sep 22.

Artigo Inglês | MEDLINE | ID: mdl-27580033

2.

Glutamate receptors from diverse animal species exhibit unexpected structural and functional diversity.

Mayer, Mark L.

J Physiol ; 599(10): 2605-2613, 2021 05.

Artigo Inglês | MEDLINE | ID: mdl-31981421

3.

Structural mechanism of glutamate receptor activation and desensitization.

Meyerson, Joel R; Kumar, Janesh; Chittori, Sagar; Rao, Prashant; Pierson, Jason; Bartesaghi, Alberto; Mayer, Mark L; Subramaniam, Sriram.

Nature ; 514(7522): 328-34, 2014 Oct 16.

Artigo Inglês | MEDLINE | ID: mdl-25119039

4.

Molecular lock regulates binding of glycine to a primitive NMDA receptor.

Yu, Alvin; Alberstein, Robert; Thomas, Alecia; Zimmet, Austin; Grey, Richard; Mayer, Mark L; Lau, Albert Y.

Proc Natl Acad Sci U S A ; 113(44): E6786-E6795, 2016 11 01.

Artigo Inglês | MEDLINE | ID: mdl-27791085

5.

Functional reconstitution of Drosophila melanogaster NMJ glutamate receptors.

Han, Tae Hee; Dharkar, Poorva; Mayer, Mark L; Serpe, Mihaela.

Proc Natl Acad Sci U S A ; 112(19): 6182-7, 2015 May 12.

Artigo Inglês | MEDLINE | ID: mdl-25918369

6.

Glycine activated ion channel subunits encoded by ctenophore glutamate receptor genes.

Alberstein, Robert; Grey, Richard; Zimmet, Austin; Simmons, David K; Mayer, Mark L.

Proc Natl Acad Sci U S A ; 112(44): E6048-57, 2015 Nov 03.

Artigo Inglês | MEDLINE | ID: mdl-26460032

7.

The Challenge of Interpreting Glutamate-Receptor Ion-Channel Structures.

Mayer, Mark L.

Biophys J ; 113(10): 2143-2151, 2017 Nov 21.

Artigo Inglês | MEDLINE | ID: mdl-28844473

8.

Functional insights from glutamate receptor ion channel structures.

Kumar, Janesh; Mayer, Mark L.

Annu Rev Physiol ; 75: 313-37, 2013.

Artigo Inglês | MEDLINE | ID: mdl-22974439

9.

Glutamate receptor desensitization is mediated by changes in quaternary structure of the ligand binding domain.

Schauder, David M; Kuybeda, Oleg; Zhang, Jinjin; Klymko, Katherine; Bartesaghi, Alberto; Borgnia, Mario J; Mayer, Mark L; Subramaniam, Sriram.

Proc Natl Acad Sci U S A ; 110(15): 5921-6, 2013 Apr 09.

Artigo Inglês | MEDLINE | ID: mdl-23530186

10.

Analysis of protein interactions with picomolar binding affinity by fluorescence-detected sedimentation velocity.

Zhao, Huaying; Mayer, Mark L; Schuck, Peter.

Anal Chem ; 86(6): 3181-7, 2014 Mar 18.

Artigo Inglês | MEDLINE | ID: mdl-24552356

11.

Expression and Functional Analysis of Ctenophore Glutamate Receptor Genes.

Mayer, Mark L.

Methods Mol Biol ; 2757: 259-268, 2024.

Artigo Inglês | MEDLINE | ID: mdl-38668971

12.

Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization.

Chaudhry, Charu; Weston, Matthew C; Schuck, Peter; Rosenmund, Christian; Mayer, Mark L.

EMBO J ; 28(10): 1518-30, 2009 May 20.

Artigo Inglês | MEDLINE | ID: mdl-19339989

13.

Domain organization and function in GluK2 subtype kainate receptors.

Das, Utpal; Kumar, Janesh; Mayer, Mark L; Plested, Andrew J R.

Proc Natl Acad Sci U S A ; 107(18): 8463-8, 2010 May 04.

Artigo Inglês | MEDLINE | ID: mdl-20404149

14.

Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors.

Yao, Yongneng; Harrison, Chris B; Freddolino, Peter L; Schulten, Klaus; Mayer, Mark L.

EMBO J ; 27(15): 2158-70, 2008 Aug 06.

Artigo Inglês | MEDLINE | ID: mdl-18636091

15.

Glutamate receptors at atomic resolution.

Mayer, Mark L.

Nature ; 440(7083): 456-62, 2006 Mar 23.

Artigo Inglês | MEDLINE | ID: mdl-16554805

16.

Energetics of glutamate receptor ligand binding domain dimer assembly are modulated by allosteric ions.

Chaudhry, Charu; Plested, Andrew J R; Schuck, Peter; Mayer, Mark L.

Proc Natl Acad Sci U S A ; 106(30): 12329-34, 2009 Jul 28.

Artigo Inglês | MEDLINE | ID: mdl-19617541

17.

Structure and mechanism of kainate receptor modulation by anions.

Plested, Andrew J R; Mayer, Mark L.

Neuron ; 53(6): 829-41, 2007 Mar 15.

Artigo Inglês | MEDLINE | ID: mdl-17359918

18.

Conformational restriction blocks glutamate receptor desensitization.

Weston, Matthew C; Schuck, Peter; Ghosal, Alokesh; Rosenmund, Christian; Mayer, Mark L.

Nat Struct Mol Biol ; 13(12): 1120-7, 2006 Dec.

Artigo Inglês | MEDLINE | ID: mdl-17115050

19.

Structural biology of kainate receptors.

Mayer, Mark L.

Neuropharmacology ; 190: 108511, 2021 06 01.

Artigo Inglês | MEDLINE | ID: mdl-33798545

20.

Partial agonists go molecular.

Mayer, Mark L.

Trends Pharmacol Sci ; 42(7): 507-509, 2021 07.

Artigo Inglês | MEDLINE | ID: mdl-33965248

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Structural basis of kainate subtype glutamate receptor desensitization.

Glutamate receptors from diverse animal species exhibit unexpected structural and functional diversity.

Structural mechanism of glutamate receptor activation and desensitization.

Molecular lock regulates binding of glycine to a primitive NMDA receptor.

Functional reconstitution of Drosophila melanogaster NMJ glutamate receptors.

Glycine activated ion channel subunits encoded by ctenophore glutamate receptor genes.

The Challenge of Interpreting Glutamate-Receptor Ion-Channel Structures.

Functional insights from glutamate receptor ion channel structures.

Glutamate receptor desensitization is mediated by changes in quaternary structure of the ligand binding domain.

Analysis of protein interactions with picomolar binding affinity by fluorescence-detected sedimentation velocity.

Expression and Functional Analysis of Ctenophore Glutamate Receptor Genes.

Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization.

Domain organization and function in GluK2 subtype kainate receptors.

Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors.

Glutamate receptors at atomic resolution.

Energetics of glutamate receptor ligand binding domain dimer assembly are modulated by allosteric ions.

Structure and mechanism of kainate receptor modulation by anions.

Conformational restriction blocks glutamate receptor desensitization.

Structural biology of kainate receptors.

Partial agonists go molecular.