Detalhe da pesquisa
1.
Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA), updates in 2022-2023. Cerebrovascular disease and the failure of elimination of Amyloid-ß from the brain and retina with age and Alzheimer's disease: Opportunities for therapy.
Alzheimers Dement
; 20(2): 1421-1435, 2024 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-37897797
2.
Development of a quantitative semi-mechanistic model of Alzheimer's disease based on the amyloid/tau/neurodegeneration framework (the Q-ATN model).
Alzheimers Dement
; 19(6): 2287-2297, 2023 06.
Artigo
Inglês
| MEDLINE | ID: mdl-36454709
3.
Ocular Half-Life of Intravitreal Biologics in Humans and Other Species: Meta-Analysis and Model-Based Prediction.
Mol Pharm
; 17(2): 695-709, 2020 02 03.
Artigo
Inglês
| MEDLINE | ID: mdl-31876425
4.
Theoretical Insights into the Retinal Dynamics of Vascular Endothelial Growth Factor in Patients Treated with Ranibizumab, Based on an Ocular Pharmacokinetic/Pharmacodynamic Model.
Mol Pharm
; 15(7): 2770-2784, 2018 07 02.
Artigo
Inglês
| MEDLINE | ID: mdl-29734810
5.
An in silico model of retinal cholesterol dynamics (RCD model): insights into the pathophysiology of dry AMD.
J Lipid Res
; 58(7): 1325-1337, 2017 07.
Artigo
Inglês
| MEDLINE | ID: mdl-28442497
6.
Ocular Pharmacokinetics of Therapeutic Antibodies Given by Intravitreal Injection: Estimation of Retinal Permeabilities Using a 3-Compartment Semi-Mechanistic Model.
Mol Pharm
; 14(8): 2690-2696, 2017 08 07.
Artigo
Inglês
| MEDLINE | ID: mdl-28631484
7.
Evaluation of HDL-modulating interventions for cardiovascular risk reduction using a systems pharmacology approach.
J Lipid Res
; 57(1): 46-55, 2016 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-26522778
8.
A Mechanistic Model of the Intravitreal Pharmacokinetics of Large Molecules and the Pharmacodynamic Suppression of Ocular Vascular Endothelial Growth Factor Levels by Ranibizumab in Patients with Neovascular Age-Related Macular Degeneration.
Mol Pharm
; 13(9): 2941-50, 2016 09 06.
Artigo
Inglês
| MEDLINE | ID: mdl-26726925
9.
An in-silico model of lipoprotein metabolism and kinetics for the evaluation of targets and biomarkers in the reverse cholesterol transport pathway.
PLoS Comput Biol
; 10(3): e1003509, 2014 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-24625468
11.
Effects of Testosterone Administration for 3 Years on Subclinical Atherosclerosis Progression in Older Men With Low or Low-Normal Testosterone Levels: A Randomized Clinical Trial.
JAMA
; 314(6): 570-81, 2015 Aug 11.
Artigo
Inglês
| MEDLINE | ID: mdl-26262795
12.
Adverse events associated with testosterone administration.
N Engl J Med
; 363(2): 109-22, 2010 Jul 08.
Artigo
Inglês
| MEDLINE | ID: mdl-20592293
13.
A comparison of the theoretical relationship between HDL size and the ratio of HDL cholesterol to apolipoprotein A-I with experimental results from the Women's Health Study.
Clin Chem
; 59(6): 949-58, 2013 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-23426429
14.
A semi-mechanistic model of the relationship between average glucose and HbA1c in healthy and diabetic subjects.
J Pharmacokinet Pharmacodyn
; 40(2): 129-42, 2013 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-23307170
15.
Effect of testosterone replacement on response to sildenafil citrate in men with erectile dysfunction: a parallel, randomized trial.
Ann Intern Med
; 157(10): 681-91, 2012 Nov 20.
Artigo
Inglês
| MEDLINE | ID: mdl-23165659
16.
Quantitative systems pharmacology model of the amyloid pathway in Alzheimer's disease: Insights into the therapeutic mechanisms of clinical candidates.
CPT Pharmacometrics Syst Pharmacol
; 12(1): 62-73, 2023 01.
Artigo
Inglês
| MEDLINE | ID: mdl-36281062
17.
Effect of testosterone supplementation with and without a dual 5α-reductase inhibitor on fat-free mass in men with suppressed testosterone production: a randomized controlled trial.
JAMA
; 307(9): 931-9, 2012 Mar 07.
Artigo
Inglês
| MEDLINE | ID: mdl-22396515
18.
In silico exploration of amyloid-related imaging abnormalities in the gantenerumab open-label extension trials using a semi-mechanistic model.
Alzheimers Dement (N Y)
; 8(1): e12306, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-35676943
19.
A Baseline Score to Predict Response to Ranibizumab Treatment in Neovascular Age-Related Macular Degeneration.
Transl Vis Sci Technol
; 10(6): 11, 2021 05 03.
Artigo
Inglês
| MEDLINE | ID: mdl-34111259
20.
Quantitative proteomic profiling of white matter in cases of cerebral amyloid angiopathy reveals upregulation of extracellular matrix proteins and clusterin.
Free Neuropathol
; 12020 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-37283687