Is hypovitaminosis D associated with abdominal aortic aneurysm, and is there a dose-response relationship?

OBJECTIVE: This study aims to investigate the association between plasma 25-hydroxyvitamin D (25(OH)D) concentrations with the presence of abdominal aortic aneurysm (AAA) and aortic diameter. DESIGN: An observational study of 4233 community-dwelling men aged 70-88 years, who participated in a randomised controlled trial of screening for AAA. METHODS: Infrarenal aortic diameter measured by ultrasound and 25(OH)D by immunoassay. RESULTS: A total of 311 men (7.4%) with AAA (defined as aortic diameter ≥ 30 mm) comprised the study. Multivariable models were adjusted for age, smoking, cardiovascular disease, hypertension, diabetes, dyslipidaemia, body mass index and serum creatinine concentration. Amongst men with the lowest 25(OH)D quartile of values compared with the highest quartile, the adjusted odds ratio of having an AAA increased in a graded fashion from 1.23 (95% confidence interval (CI) 0.87-1.73) for AAA ≥ 30 mm to 5.42 (95% CI 1.85-15.88) for AAA ≥ 40 mm. Similarly, there was a dose-response relationship between 25(OH)D concentrations and the size of the AAA: every 10-nmol l(-1) decrease in 25(OH)D levels was associated with 0.49 mm (95% CI 0.11-0.87) increase in mean aortic diameter. CONCLUSIONS: Low vitamin D status is associated with the presence of larger AAA in older men, and there is a graded inverse relationship between 25(OH)D concentrations and AAA diameter. Further research is needed to clarify the mechanisms underlying these associations.

Associations of total osteocalcin with all-cause and cardiovascular mortality in older men. The Health In Men Study.

SUMMARY: In older men, both lower and higher total osteocalcin levels predict increased all-cause mortality, with comparable associations for cardiovascular and non-cardiovascular deaths. Differences in osteocalcin levels might influence glucose metabolism and thereby cardiovascular risk, or reflect changes in bone turnover thus representing a marker for poorer health outcomes. INTRODUCTION: Reduced levels of total osteocalcin (TOC) are associated with adiposity, insulin resistance and type 2 diabetes, implying this bone-derived peptide might modulate cardiovascular risk. However, there are few longitudinal data relating TOC levels to survival. We examined associations of TOC level with all-cause and cardiovascular mortality in older men. METHODS: We conducted a prospective cohort study of community-dwelling men aged 70-89 years. Aliquots of plasma collected at baseline (2001-2004) were assayed for TOC. Incidence and causes of death to 31 December 2008 were ascertained using data linkage. Cox regression analyses were performed with adjustment for conventional cardiovascular risk factors. RESULTS: From 3,542 men followed for median 5.2 years there were 572 deaths (16.1%). Mortality was lowest in men with TOC levels in the second quintile (12.6%). In multivariate analyses, men with TOC in the lowest and highest quintiles of values had increased all-cause mortality (Q1 vs Q2: hazard ratio [HR], 1.36; 95% confidence interval 1.02-1.80 and Q5 vs Q2: HR, 1.53, 95% CI 1.18-1.98). Men with low TOC levels had similar HR for cardiovascular and non-cardiovascular deaths (Q1 vs Q2: HR, 1.35 and 1.30 respectively). Higher TOC levels predicted cardiovascular disease (CVD)-related mortality (Q5 vs Q2, HR, 1.69, 95% CI 1.09-2.64). CONCLUSIONS: TOC predicts all-cause and CVD-related mortality in community-dwelling older men. However, the relationship is U shaped with men at both ends of the distribution at increased risk. Further investigation is required to clarify whether the underlying mechanisms involve altered bone turnover or relate specifically to the biological activity of osteocalcin.

Perinatal risk factors for developmental dysplasia of the hip.

AIMS: To identify perinatal risk factors for developmental dysplasia of the hip (DDH) and define the risk for each factor. METHODS: In this case control study, using logistic regression analysis, all 1127 cases of isolated DDH live born in South Australia in 1986-93 and notified to the South Australian Birth Defects Register were included; controls comprised 150130 live births in South Australia during the same period without any notified congenital abnormalities. RESULTS: Breech presentation, oligohydramnios, female sex and primiparity were confirmed as risk factors for DDH. Significant findings were an increased risk for vaginal delivery over caesarean section for breech presentation (as well as an increased risk for emergency section over elective section), high birthweight (> or = 4000 g), postmaturity and older maternal age; multiple births and preterm births had a reduced risk. There was no increased risk for caesarean section in the absence of breech presentation. For breech presentation, the risk of DDH was estimated to be at least 2.7% for girls and 0.8% for boys; a combination of factors increased the risk. CONCLUSIONS: It is suggested that the risk factors identified be used as indications for repeat screening at 6 weeks of age and whenever possible in infancy. Other indications are family history and associated abnormalities.

Mortality from aortic aneurysms in Australia, 1968 to 1997.

OBJECTIVES: Describe trends in mortality for aortic aneurysms in Australia for the period 1968 to 1997. DESIGN: Descriptive study of time trends in mortality. MAIN OUTCOME MEASURE: Age-sex-standardised mortality rates with statistical analysis of trends using negative-binomial regression. RESULTS: While overall mortality rates for aortic aneurysms remained relatively constant for the period 1968 to 1992 in Australia, there has been a small but significant reduction in the rate from then until the end of the series in 1997. When different types of aneurysms are considered, there have been increases in the rates associated with abdominal aortic aneurysms and thoracic aortic aneurysms, while those for dissecting aortic aneurysms have declined. Most significantly, mortality rates for unspecified aortic aneurysms have declined. CONCLUSION: Aortic aneurysm mortality has declined in Australia in recent years. The reasons for this are unclear. While there have been increases associated with abdominal aortic aneurysm mortality, this is likely to be a result of more precise coding of death rather than any real increase in mortality.

A new method of breath testing the general driving population.

The efficacy of drinking-driving countermeasures can be assessed in several ways, including reported changes in attitudes and behavioral intent as well as changes in crash rates. However, few studies have examined the changes in actual drinking-driving behavior. A method of surveying the blood alcohol concentrations (BACs) of drivers, without either police intervention or disruption to traffic flow, was developed in South Australia. This method, which has been used successfully to test approximately 50,000 drivers, is described in detail.

Validation of a water consumption questionnaire for a study of the adverse health outcomes associated with disinfection by-products.

The aim of this study was to assess the validity and reliability of a questionnaire to estimate water exposure through drinking, showering, bathing or swimming. Forty-seven pregnant women were recruited from antenatal or exercise classes and were randomly allocated into three groups. The first group completed the water exposure questionnaire one-week apart. The second group completed a three-day diary and then the questionnaire. The third group completed the questionnaire first followed by the diary. Agreement was assessed by the Intraclass correlation coefficient (ICC) and the Kappa statistic. The questionnaire demonstrated good reliability (ICC 0.93 for water consumption and 0.91 for time spent showering). With regard to validity, average daily water consumption was estimated to be 8.1 glasses/day (2 litres) from the diary compared with 12.2 (3 litres) from the questionnaire. The ICCs comparing the diary and questionnaire responses were 0.31 for water consumption and 0.72 for showering. The water exposure questionnaire overestimated levels of exposure when compared with diary-reporting of consumption. While a water exposure questionnaire may be a less intrusive research instrument than a diary, further development is required to improve the validity of this instrument.

Barriers to success for an evidence-based guideline for chronic obstructive pulmonary disease.

OBJECTIVES: To evaluate 1) barriers to clinical guideline use and 2) the relationship between guideline use and inpatient outcomes in chronic obstructive pulmonary disease (COPD). METHODS: 1) Four focus groups of specific health professions (n = 30), from three metropolitan hospitals, and interview of 99 medical officers (MOs), linked to 349 admissions, both guided by behavioural modelling theory; 2) association between guideline use and patient outcomes (length of hospital stay > or = 14 days, and readmission within 28 or 90 days) was evaluated in a cohort of 405 COPD patients. RESULTS: 1) In focus groups, nurses and allied health professionals emphasized facilitation issues including paperwork duplication and time limitations as barriers, but considered improved patient care outcomes as the major guideline use determinant. There were similar findings in junior MOs (nonconsultants) by both focus group and interview, with the addition of a need for a sense of ownership. Senior MOs (consultants) greatly emphasized sense of ownership. Barriers to guideline use varied between types of units. Behavioural modelling explained 49% of the variation in intention to use the guideline for MOs. For nonconsultants, habit and intention were significantly associated with extent of guideline use. 2) Patient outcomes: guideline use was not associated with length of stay or readmission. CONCLUSIONS: 1) Guideline implementation should address issues relevant to different health professions, units and seniority of profession. 2) Guideline use was not associated with reductions in readmission or length of stay.

Publicity, police resources and the effectiveness of random breath testing.

Random breath testing (RBT) of drivers by the police was introduced in South Australia in 1981 at a very low level of enforcement. As there was no lasting effect on illegal "drink driving" the resources devoted to RBT were increased in 1987. In the months after this change police doubled the number of drivers tested by RBT. Concurrent with this change in the level of enforcement of RBT was an extensive publicity campaign, which warned drinking drivers of their increased risk of detection by RBT units. A roadside breath alcohol survey, conducted in metropolitan Adelaide late at night to evaluate the effect of these changes, showed a 34% reduction in the proportion of car drivers detected with a blood alcohol concentration at or above the legal limit of 0.08 g/100 mL.

Prevalence of gastroenteritis among 4-year-old children in South Australia.

The aim of this study was to determine the prevalence of gastroenteritis among children aged 4 years in South Australia. A cross-sectional survey of 9543 South Australian children aged 4 years was undertaken. Parents completed a questionnaire on behalf of their child who had attended a pre-school health check in 1998. The questionnaire covered gastrointestinal and respiratory symptoms experienced by the child in the previous 2 weeks and other risk factors for gastroenteritis. The 2-week prevalence of gastroenteritis among 4-year-old children was 14.2%. The major risk factors for gastroenteritis were presence of persons who had gastroenteritis inside the home, contact with persons who had gastroenteritis outside the home, antibiotic use and sore throat. Medical attention was sought for 20% of children who had gastroenteritis. Gastroenteritis is a significant cause of morbidity among young children and presents a considerable burden on the community. A substantial proportion of these occurrences of highly credible gastrointestinal symptoms may be manifestations of respiratory infections.

Drink-driving in the general night-time driving population, Adelaide 1989.

A roadside breath alcohol survey was conducted by the NHMRC Road Accident Research Unit in 1989 to monitor the efficacy of random breath testing (RBT) by the police. A reduction of 40 per cent in the proportion of drivers above the legal blood alcohol limit of 0.08 g/100 ml was found to coincide with a marked increase in the level of publicity of police RBT operations. Other factors may also have contributed to these large reductions in illegal drink-driving but this result was similar to that observed in 1987 when a major increase in publicity was accompanied by an increase in the level of enforcement of RBT. Although the full effect of these reductions has diminished with time, there appears to have been a decrease in illegal drink-driving in Adelaide from 1983 to 1987 and again to 1989.

Trends in prostate cancer incidence and mortality rates in South Australia, 1977-1993.

OBJECTIVE: To investigate trends in recorded incidence and mortality rates for prostate cancer in South Australia. DESIGN: A multiple Poisson regression analysis of recorded incidence (by diagnostic period) and mortality (by year of death), after adjusting for age at diagnosis and residential location. SUBJECTS AND SETTING: 8073 patients with prostate cancer and 2659 who died of prostate cancer as notified to the South Australian Cancer Registry for 1977-1993. MAIN OUTCOME MEASURES: The relative risk of a recorded diagnosis of prostate cancer (by period of diagnosis), and of a death from prostate cancer (by year of death). RESULTS: During 1977-1989, the recorded age-standardised incidence of prostate cancer was stable, but it increased markedly thereafter. The relative risk (95% confidence limits) of diagnosed prostate cancer was 1.36 (1.29, 1.43) in 1990-1992, and 2.26 (2.12, 2.42) in 1993, when compared with 1977-1989. There was a smaller and less certain increase in prostate cancer mortality. CONCLUSIONS: The large increase in recorded incidence of prostate cancer in South Australia is thought to be due mostly to increased disclosure of latent cases from increased clinical investigations. Until there is experimental evidence of health benefits from screening and related investigations for prostate cancer in asymptomatic men, it will be difficult to reconcile benefits with costs.

Use of fake tanning lotions in the South Australian population.

OBJECTIVE: To explore the relationship between the use of fake tanning lotions and repeated sunburn among South Australian adults, with a view to informing the Anti-Cancer Foundation of South Australia's (ACFSA) policy on fake tanning products. STUDY DESIGN: Population survey. PARTICIPANTS: 2005 South Australians aged 18 years or older, selected randomly from the electronic White Pages. MAIN OUTCOME MEASURES: Self-reported use of fake tanning lotions in the past 12 months; frequency of sunburn over summer; and various sun-protective behaviours. RESULTS: 2,005 of the 2,536 eligible participants (79%) were surveyed by telephone. Fake tan use was most prevalent among women (15.9%), people aged 18-24 years (15.4%), and people with household incomes above $40 000 per year (11.9%). Fake tan users were more likely than non-users to use sunscreens (81.3% v 56.5%; P < 0.001), but less likely to take other precautions such as wearing hats (40.9% v 51.0%; P = 0.04) and protective clothing (22.3% v 34.1%; P = 0.005). They were also more likely to report having been burnt more than once over summer (26.2% v 16.5%; P = 0.025). Multivariate analysis indicates a statistically significant association between fake tan use and repeated sunburn (odds ratio, 2.07; 95% confidence interval, 1.17-3.69), which was independent of age, sex, skin type and sun-protection practices. CONCLUSION: Users of fake tanning products may be at greater risk of repeated sunburn. The ACFSA sees no justification at this stage for altering its present policy position of not actively promoting the use of fake tanning lotions as a means of reducing sunburn.

Trends in prognostic factors of melanoma in South Australia, 1981-1992: implications for health promotion.

OBJECTIVE: To analyse trends in prognostic factors at diagnosis of melanoma to indicate targets for health promotion. METHODS: Cases of melanoma notified to the South Australian Cancer Registry during 1981-1992 (1361 in situ and 4509 invasive) were analysed by tumour site, histological type, stage, thickness, period of diagnosis and sociodemographic characteristics of the patient. RESULTS: The relative probability of being diagnosed with an in-situ, rather than a thin invasive, lesion increased progressively between 1984-1986 and 1990-1992. The relative probability of having an in-situ melanoma diagnosed was: lower among those aged 80 years or more; higher among patients residing in the upper socioeconomic areas of Adelaide; high for lesions on the face; and high for lentigo maligna as opposed to superficial spreading lesions. The relative probability of invasive lesions being diagnosed when more than 1.5 mm thick decreased progressively between the 1981-1983 and 1990-1992 diagnosis periods. The relative probability of thick lesions being diagnosed was higher among older patients and for nodular lesions compared with superficial spreading or lentigo maligna lesions. Facial lesions and those in males tended to be thicker. CONCLUSIONS: There are favourable trends towards earlier detection of melanomas in South Australia, probably reflecting the effect of skin-cancer awareness campaigns. Further campaigns should emphasise early detection in people aged 60 years and over, males and residents of less affluent areas. Early detection of nodular melanomas and invasive lesions of the face also warrants special attention.

Extradural haemorrhage in infancy and childhood. A review of 35 years' experience in South Australia.

One hundred and two paediatric cases of extradural haemorrhage (EDH) were treated in Adelaide, South Australia, during the period 1954-1988; 10 were infants (0-2 years) and 92 were children (2-14 years). There were 9 deaths (mortality 8.8%). Long-term disabilities severe enough to interfere with school and/or employment were seen in 8 (7.8%) survivors. This relatively low number of adverse outcomes is partly an expression of a low incidence (5.9%) of associated intradural haematomas and few high-velocity impacts due to vehicular accidents. There is reason to believe that the results of treatment have improved in the decade 1977-1988. We attribute this in part to early diagnosis by computed tomography (CT), but a contributory factor may be earlier referrals from country centres to a paediatric trauma centre and rapid transfer, by air or road, by medical retrieval teams.

Trends in coronary artery revascularisation procedures in Western Australia, 1980-2001.

OBJECTIVES: To describe trends in the use of coronary artery revascularisation procedures (CARPs) and to determine whether or when CARP rates will stabilise. SETTING: State of Western Australia. PATIENTS: All patients treated by coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) between 1980 and 2001. DESIGN: Descriptive study. MAIN OUTCOME MEASURES: Age standardised rates of first and total CARPs, CABGs, and PCIs. RESULTS: Overall rates for both total and first CARPs among men and women rose steeply from 1980 to 1993, when they abruptly stabilised or actually started to decline. Rates in age groups under 65 years tended to rise earlier in the period and remained relatively flat, while rates for people over the age of 75 years started to rise later and were still increasing at the end of the study. CONCLUSIONS: Despite continuing increases in capacity to perform both CABG and PCI in Western Australia and evidence of continuing increases in the use of CARPs in the elderly population, rates appear to have stabilised for the first time since they were introduced.

Trends in two year risk of repeat revascularisation or death from cardiovascular disease after coronary artery bypass grafting or percutaneous coronary intervention in Western Australia, 1980-2001.

AIMS: To investigate whether, over the 21 year period 1980-2001, there had been a reduction in the risk of repeat revascularisation or death from cardiovascular disease in the cohort of all patients who were treated by coronary revascularisation in Western Australia. SETTING: State of Western Australia. PATIENTS: All patients treated by coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) between 1980 and 2001. DESIGN: Cohort study. MAIN OUTCOME MEASURES: Risk of repeat coronary artery revascularisation procedures (CARP) and risk of death from cardiovascular disease after first CARP. RESULTS: After a CABG procedure, the two year risk of repeat revascularisation remained low (less than 2%) across the period 1980-2001. For PCI, however, this risk declined significantly from 33.6% in 1985-9 to 12.4% in 2000-1. The risk of death from cardiovascular disease after a CARP declined by about 50% between 1985 and 2001. CONCLUSIONS: Outcomes such as the risk of repeat revascularisation and the risk of death from cardiovascular disease have improved significantly for patients who underwent CARPs across the period 1980-2001. This has occurred despite an increasing trend in first CARP rates among older people and those with a recent history of myocardial infarction.

Developmental dysplasia of the hip in South Australia in 1991: prevalence and risk factors.

OBJECTIVE: To determine the prevalence of developmental dysplasia of the hip (DDH) in South Australia (SA) in 1991, the proportion of cases detected in the neonatal period and the perinatal risk factors for DDH. METHODOLOGY: Cases of DDH born in SA in 1991 were identified from multiple sources and their clinical data linked to perinatal data provided by midwives; five controls per case were obtained randomly from SA livebirths without congenital abnormalities and adjusted odds ratios (OR) for potential risk factors obtained by logistic regression analysis. South Australia perinatal data were also used to estimate numbers of births with perinatal risk factors for targeted screening. RESULTS: Two hundred and six cases of isolated DDH were identified, giving a prevalence of 10.5 per 1000 births. Of these, 173 (84%) had been detected in the neonatal period. The perinatal risk factors for DDH were identified as breech presentation (OR 9.65), female babies (OR 4.04), first births (OR 1.91) and maternal age of 25 years or more (OR 1.53). Screening breech and firstborn female babies (23% of births) would yield approximately 51% of cases of DDH. CONCLUSIONS: Isolated DDH had a prevalence of 10.5 per 1000 births and 84% of cases had been detected in the neonatal period in SA. Repeated screening during infancy of "at risk' groups of babies is recommended.

Trends in hospital readmission for asthma: has the Australian National Asthma Campaign had an effect?

OBJECTIVES: To describe patterns of hospital readmission for asthma in South Australia from 1989 to 1996, in relation to implementation of the National Asthma Campaign. DESIGN AND SETTING: A comparison of hospital admissions in South Australia of patients aged between one year and 49 years for three conditions: asthma (or respiratory failure with asthma as an underlying condition) and two control conditions--diabetes and epilepsy. Individuals were identified by Medicare number and date of birth. OUTCOME MEASURES: Hospital readmission within 28 days and within one year. RESULTS: Overall, by 1996, there was a statistically significant decline in the risk of readmission for asthma within 28 days of 18% and within one year of 17% compared with 1989 readmission rates. There were no reductions in the risk of readmission for diabetes or epilepsy, suggesting that the decline in risk of readmission for asthma was greater than the underlying effects of general changes in hospital casemix. CONCLUSIONS: The decline in risk of readmission may reflect changes in asthma severity or improved management practices. However, hospital readmission rates still remain high, and to further reduce readmissions for asthma there is a need to identify factors related to presentation for asthma at accident and emergency departments.