Detalhe da pesquisa
1.
Small molecule inhibitors of PCSK9. SAR investigations of head and amine groups.
Bioorg Med Chem Lett
; 92: 129394, 2023 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37379958
2.
Preclinical characterization and IND-enabling safety studies for PNT001, an antibody that recognizes cis-pT231 tau.
Alzheimers Dement
; 19(10): 4662-4674, 2023 10.
Artigo
Inglês
| MEDLINE | ID: mdl-37002928
3.
Structure-function relationships of the soluble form of the antiaging protein Klotho have therapeutic implications for managing kidney disease.
J Biol Chem
; 295(10): 3115-3133, 2020 03 06.
Artigo
Inglês
| MEDLINE | ID: mdl-32005658
4.
Correction: Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain.
PLoS Biol
; 16(4): e1002628, 2018 04.
Artigo
Inglês
| MEDLINE | ID: mdl-29664898
5.
Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain.
PLoS Biol
; 15(3): e2001882, 2017 03.
Artigo
Inglês
| MEDLINE | ID: mdl-28323820
6.
Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing.
J Am Chem Soc
; 140(21): 6596-6603, 2018 05 30.
Artigo
Inglês
| MEDLINE | ID: mdl-29668265
7.
Discovery of N-(piperidin-3-yl)-N-(pyridin-2-yl)piperidine/piperazine-1-carboxamides as small molecule inhibitors of PCSK9.
Bioorg Med Chem Lett
; 28(23-24): 3685-3688, 2018 12 15.
Artigo
Inglês
| MEDLINE | ID: mdl-30482620
8.
Liver-Targeted Small-Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis.
Angew Chem Int Ed Engl
; 56(51): 16218-16222, 2017 12 18.
Artigo
Inglês
| MEDLINE | ID: mdl-29073340
9.
From partial to full agonism: identification of a novel 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole as a full agonist of the human GPR119 receptor.
Bioorg Med Chem Lett
; 23(1): 194-7, 2013 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23177788
10.
Identification of potent, selective, CNS-targeted inverse agonists of the ghrelin receptor.
Bioorg Med Chem Lett
; 23(19): 5410-4, 2013 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23953189
11.
Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor.
Bioorg Med Chem Lett
; 22(13): 4281-7, 2012 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22677316
12.
Intrinsic electrophilicity of a 4-substituted-5-cyano-6-(2-methylpyridin-3-yloxy)pyrimidine derivative: structural characterization of glutathione conjugates in vitro.
Chem Res Toxicol
; 24(2): 269-78, 2011 Feb 18.
Artigo
Inglês
| MEDLINE | ID: mdl-21288051
13.
Oxidative metabolism of a quinoxaline derivative by xanthine oxidase in rodent plasma.
Chem Res Toxicol
; 24(12): 2207-16, 2011 Dec 19.
Artigo
Inglês
| MEDLINE | ID: mdl-21939274
14.
Design and evaluation of a 2-(2,3,6-trifluorophenyl)acetamide derivative as an agonist of the GPR119 receptor.
Bioorg Med Chem Lett
; 21(5): 1306-9, 2011 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21310611
15.
PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease.
J Med Chem
; 64(1): 326-342, 2021 01 14.
Artigo
Inglês
| MEDLINE | ID: mdl-33356244
16.
Continued exploration of the triazolopyridine scaffold as a platform for p38 MAP kinase inhibition.
Bioorg Med Chem Lett
; 20(2): 469-73, 2010 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19969459
17.
Design, synthesis, and pharmacology of fluorescently labeled analogs of serotonin: application to screening of the 5-HT2C receptor.
J Biomol Screen
; 14(4): 360-70, 2009 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-19403919
18.
Biochemical basis for differences in metabolism-dependent genotoxicity by two diazinylpiperazine-based 5-HT2C receptor agonists.
Bioorg Med Chem Lett
; 19(6): 1559-63, 2009 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19246199
19.
Permeability of Cyclic Peptide Macrocycles and Cyclotides and Their Potential as Therapeutics.
ACS Med Chem Lett
; 10(7): 1026-1032, 2019 Jul 11.
Artigo
Inglês
| MEDLINE | ID: mdl-31312403
20.
Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat Struct Mol Biol
; 26(6): 501-509, 2019 06.
Artigo
Inglês
| MEDLINE | ID: mdl-31160784