Detalhe da pesquisa
1.
Oxamniquine derivatives overcome Praziquantel treatment limitations for Schistosomiasis.
PLoS Pathog
; 19(7): e1011018, 2023 07.
Artigo
Inglês
| MEDLINE | ID: mdl-37428793
2.
Asymmetric Synthesis of CIDD-0072424 via an Enantioselective Nitro-Mannich Reaction: A Central Nervous System Penetrant, Selective Small Molecule Inhibitor of Protein Kinase C Epsilon.
J Org Chem
; 89(7): 5134-5141, 2024 04 05.
Artigo
Inglês
| MEDLINE | ID: mdl-38489762
3.
Modulation of α1ß3γ2 GABAA receptors expressed in X. laevis oocytes using a propofol photoswitch tethered to the transmembrane helix.
Proc Natl Acad Sci U S A
; 118(8)2021 02 23.
Artigo
Inglês
| MEDLINE | ID: mdl-33593898
4.
A modular PROTAC design for target destruction using a degradation signal based on a single amino acid.
J Biol Chem
; 294(41): 15172-15175, 2019 10 11.
Artigo
Inglês
| MEDLINE | ID: mdl-31511327
5.
Synthesis and SAR of novel capsazepine analogs with significant anti-cancer effects in multiple cancer types.
Bioorg Med Chem
; 27(1): 208-215, 2019 01 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30528162
6.
The novel capsazepine analog, CIDD-99, significantly inhibits oral squamous cell carcinoma in vivo through a TRPV1-independent induction of ER stress, mitochondrial dysfunction, and apoptosis.
J Oral Pathol Med
; 48(5): 389-399, 2019 May.
Artigo
Inglês
| MEDLINE | ID: mdl-30825343
7.
Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy.
J Biol Chem
; 292(27): 11154-11164, 2017 07 07.
Artigo
Inglês
| MEDLINE | ID: mdl-28536265
8.
Noncoupled Fluorescent Assay for Direct Real-Time Monitoring of Nicotinamide N-Methyltransferase Activity.
Biochemistry
; 56(6): 824-832, 2017 Feb 14.
Artigo
Inglês
| MEDLINE | ID: mdl-28121423
9.
Design, synthesis, and characterization of novel, nonquaternary reactivators of GF-inhibited human acetylcholinesterase.
Bioorg Med Chem Lett
; 24(7): 1711-4, 2014 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24630558
10.
Corrigendum to "Synthesis and SAR of novel capsazepine analogs with significant anti-cancer effects in multiple cancer types" [Bioorg. Med. Chem. 27 (1) (2019) 208-215].
Bioorg Med Chem
; 27(11): 2280, 2019 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31014563
11.
Addressing the oxamniquine in vitro-in vivo paradox to facilitate a new generation of anti-schistosome treatments.
Int J Parasitol Drugs Drug Resist
; 21: 65-73, 2023 04.
Artigo
Inglês
| MEDLINE | ID: mdl-36758271
12.
Preclinical Development of Brain Permeable ERß Agonist for the Treatment of Glioblastoma.
Mol Cancer Ther
; 22(11): 1248-1260, 2023 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-37493258
13.
18F-FDG microPET imaging detects early transient response to an IGF1R inhibitor in genetically engineered rhabdomyosarcoma models.
Pediatr Blood Cancer
; 59(3): 485-92, 2012 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-22238194
14.
Inhibition of Ca2+ entry by capsazepine analog CIDD-99 prevents oral squamous carcinoma cell proliferation.
Front Physiol
; 13: 969000, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-36187775
15.
Schistosome Sulfotransferases: Mode of Action, Expression and Localization.
Pharmaceutics
; 14(7)2022 Jul 06.
Artigo
Inglês
| MEDLINE | ID: mdl-35890311
16.
Tamoxifen Derivatives Alter Retromer-Dependent Endosomal Tubulation and Sorting to Block Retrograde Trafficking of Shiga Toxins.
Toxins (Basel)
; 13(6)2021 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-34203879
17.
Rational approach to drug discovery for human schistosomiasis.
Int J Parasitol Drugs Drug Resist
; 16: 140-147, 2021 08.
Artigo
Inglês
| MEDLINE | ID: mdl-34111649
18.
Biaryl piperidines as potent and selective delta opioid receptor ligands.
Bioorg Med Chem Lett
; 20(2): 503-7, 2010 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20015649
19.
Molecular basis for hycanthone drug action in schistosome parasites.
Mol Biochem Parasitol
; 236: 111257, 2020 03.
Artigo
Inglês
| MEDLINE | ID: mdl-32027942
20.
Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum?
Int J Parasitol Drugs Drug Resist
; 13: 8-15, 2020 08.
Artigo
Inglês
| MEDLINE | ID: mdl-32315953