Detalhe da pesquisa
1.
Molecular basis for substrate recruitment to the PRMT5 methylosome.
Mol Cell
; 81(17): 3481-3495.e7, 2021 09 02.
Artigo
Inglês
| MEDLINE | ID: mdl-34358446
2.
The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA synthetase druggability.
J Biol Chem
; 289(31): 21651-62, 2014 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24936059
3.
Novel broad-spectrum inhibitors of bacterial methionine aminopeptidase.
Bioorg Med Chem Lett
; 25(16): 3301-6, 2015 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26099541
4.
Identification of Small Molecule Inhibitors of PPM1D Using a Novel Drug Discovery Platform.
bioRxiv
; 2024 May 21.
Artigo
Inglês
| MEDLINE | ID: mdl-38826457
5.
Novel rapidly diversifiable antimicrobial RNA polymerase switch region inhibitors with confirmed mode of action in Haemophilus influenzae.
J Bacteriol
; 194(20): 5504-12, 2012 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-22843845
6.
Time-dependent, reversible, oxaborole inhibition of Escherichia coli leucyl-tRNA synthetase measured with a continuous fluorescence assay.
Anal Biochem
; 431(1): 48-53, 2012 Dec 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22975201
7.
Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction.
J Med Chem
; 64(15): 11148-11168, 2021 08 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34342224
8.
Antibacterial FabH Inhibitors with Mode of Action Validated in Haemophilus influenzae by in Vitro Resistance Mutation Mapping.
ACS Infect Dis
; 2(7): 456-64, 2016 07 08.
Artigo
Inglês
| MEDLINE | ID: mdl-27626097
9.
Illicit Transport via Dipeptide Transporter Dpp is Irrelevant to the Efficacy of Negamycin in Mouse Thigh Models of Escherichia coli Infection.
ACS Infect Dis
; 1(5): 222-30, 2015 May 08.
Artigo
Inglês
| MEDLINE | ID: mdl-27622650
10.
4,5-Disubstituted 6-Aryloxy-1,3-dihydrobenzo[c][1,2]oxaboroles Are Broad-Spectrum Serine ß-Lactamase Inhibitors.
ACS Infect Dis
; 1(7): 310-6, 2015 Jul 10.
Artigo
Inglês
| MEDLINE | ID: mdl-27622821
11.
X-ray crystal structures of Escherichia coli RNA polymerase with switch region binding inhibitors enable rational design of squaramides with an improved fraction unbound to human plasma protein.
J Med Chem
; 58(7): 3156-71, 2015 Apr 09.
Artigo
Inglês
| MEDLINE | ID: mdl-25798859
12.
Structural Insights Lead to a Negamycin Analogue with Improved Antimicrobial Activity against Gram-Negative Pathogens.
ACS Med Chem Lett
; 6(8): 930-5, 2015 Aug 13.
Artigo
Inglês
| MEDLINE | ID: mdl-26288696
13.
Pyrazolopyrimidines establish MurC as a vulnerable target in Pseudomonas aeruginosa and Escherichia coli.
ACS Chem Biol
; 9(10): 2274-82, 2014 Oct 17.
Artigo
Inglês
| MEDLINE | ID: mdl-25035921
14.
Selective inhibitors of bacterial t-RNA-(N(1)G37) methyltransferase (TrmD) that demonstrate novel ordering of the lid domain.
J Med Chem
; 56(18): 7278-88, 2013 Sep 26.
Artigo
Inglês
| MEDLINE | ID: mdl-23981144
15.
Synthesis of amine- and thiol-modified nucleoside phosphoramidites for site-specific introduction of biophysical probes into RNA.
J Org Chem
; 70(11): 4284-99, 2005 May 27.
Artigo
Inglês
| MEDLINE | ID: mdl-15903302