Detalhe da pesquisa
1.
Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.
Cell
; 161(6): 1252-65, 2015 Jun 04.
Artigo
Inglês
| MEDLINE | ID: mdl-26046436
2.
Suppression of Kv3.3 channels by antisense oligonucleotides reverses biochemical effects and motor impairment in spinocerebellar ataxia type 13 mice.
FASEB J
; 35(12): e22053, 2021 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34820911
3.
The Opioid Crisis and the Future of Addiction and Pain Therapeutics.
J Pharmacol Exp Ther
; 371(2): 396-408, 2019 11.
Artigo
Inglês
| MEDLINE | ID: mdl-31481516
4.
Scalable Measurements of Intrinsic Excitability in Human iPS Cell-Derived Excitatory Neurons Using All-Optical Electrophysiology.
Neurochem Res
; 44(3): 714-725, 2019 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-30603979
5.
Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels.
Proc Natl Acad Sci U S A
; 110(21): 8732-7, 2013 May 21.
Artigo
Inglês
| MEDLINE | ID: mdl-23650380
6.
Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel.
Proc Natl Acad Sci U S A
; 109(29): 11866-71, 2012 Jul 17.
Artigo
Inglês
| MEDLINE | ID: mdl-22745159
7.
Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold.
Bioorg Med Chem Lett
; 24(16): 3968-73, 2014 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25017033
8.
A phenotypic screening platform for chronic pain therapeutics using all-optical electrophysiology.
Pain
; 165(4): 922-940, 2024 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-37963235
9.
Characterization of the substituted N-triazole oxindole TROX-1, a small-molecule, state-dependent inhibitor of Ca(V)2 calcium channels.
Mol Pharmacol
; 81(3): 488-97, 2012 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-22188924
10.
Selective, direct activation of high-conductance, calcium-activated potassium channels causes smooth muscle relaxation.
Mol Pharmacol
; 81(4): 567-77, 2012 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-22241372
11.
Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.
J Biol Chem
; 286(38): 33436-46, 2011 Sep 23.
Artigo
Inglês
| MEDLINE | ID: mdl-21795696
12.
Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator.
Bioorg Med Chem Lett
; 22(18): 5936-41, 2012 Sep 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22910039
13.
Asymmetric synthesis and evaluation of a hydroxyphenylamide voltage-gated sodium channel blocker in human prostate cancer xenografts.
Bioorg Med Chem
; 20(6): 2180-8, 2012 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22364743
14.
Homozygous might be hemizygous: CRISPR/Cas9 editing in iPSCs results in detrimental on-target defects that escape standard quality controls.
Stem Cell Reports
; 17(4): 993-1008, 2022 04 12.
Artigo
Inglês
| MEDLINE | ID: mdl-35276091
15.
'Channeling' therapeutic discovery for epileptic encephalopathy through iPSC technologies.
Trends Pharmacol Sci
; 43(5): 392-405, 2022 05.
Artigo
Inglês
| MEDLINE | ID: mdl-35427475
16.
Highly Parallelized, Multicolor Optogenetic Recordings of Cellular Activity for Therapeutic Discovery Applications in Ion Channels and Disease-Associated Excitable Cells.
Front Mol Neurosci
; 15: 896320, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-35860501
17.
Identification of novel and selective Kv2 channel inhibitors.
Mol Pharmacol
; 80(6): 959-64, 2011 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-21948463
18.
A potent and selective indole N-type calcium channel (Ca(v)2.2) blocker for the treatment of pain.
Bioorg Med Chem Lett
; 21(2): 869-73, 2011 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21195616
19.
Probing Synaptic Signaling with Optogenetic Stimulation and Genetically Encoded Calcium Reporters.
Methods Mol Biol
; 2191: 109-134, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-32865742
20.
Analgesic effects of a substituted N-triazole oxindole (TROX-1), a state-dependent, voltage-gated calcium channel 2 blocker.
J Pharmacol Exp Ther
; 334(2): 545-55, 2010 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-20439438