Detalhe da pesquisa
1.
Engineering a therapeutic lectin by uncoupling mitogenicity from antiviral activity.
Cell
; 163(3): 746-58, 2015 Oct 22.
Artigo
Inglês
| MEDLINE | ID: mdl-26496612
2.
A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo.
Nat Chem Biol
; 19(6): 703-711, 2023 06.
Artigo
Inglês
| MEDLINE | ID: mdl-36732620
3.
Structure of the zinc-finger antiviral protein in complex with RNA reveals a mechanism for selective targeting of CG-rich viral sequences.
Proc Natl Acad Sci U S A
; 116(48): 24303-24309, 2019 11 26.
Artigo
Inglês
| MEDLINE | ID: mdl-31719195
4.
Probing the interaction between the histone methyltransferase/deacetylase subunit RBBP4/7 and the transcription factor BCL11A in epigenetic complexes.
J Biol Chem
; 293(6): 2125-2136, 2018 02 09.
Artigo
Inglês
| MEDLINE | ID: mdl-29263092
5.
Differential Conformational Dynamics Encoded by the Linker between Quasi RNA Recognition Motifs of Heterogeneous Nuclear Ribonucleoprotein H.
J Am Chem Soc
; 140(37): 11661-11673, 2018 09 19.
Artigo
Inglês
| MEDLINE | ID: mdl-30122033
6.
Clarifying the Copper Coordination Environment in a de Novo Designed Red Copper Protein.
Inorg Chem
; 57(19): 12291-12302, 2018 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30226758
7.
High-resolution crystal structures of Colocasia esculenta tarin lectin.
Glycobiology
; 27(1): 50-56, 2017 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27558840
8.
Structural analysis and binding properties of isoforms of tarin, the GNA-related lectin from Colocasia esculenta.
Biochim Biophys Acta
; 1854(1): 20-30, 2015 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-25448725
9.
Structural basis for the recognition of peptide RJPXD33 by acyltransferases in lipid A biosynthesis.
J Biol Chem
; 289(22): 15527-35, 2014 May 30.
Artigo
Inglês
| MEDLINE | ID: mdl-24742680
10.
Structural basis for the enhanced stability of highly fluorinated proteins.
Proc Natl Acad Sci U S A
; 109(13): 4810-5, 2012 Mar 27.
Artigo
Inglês
| MEDLINE | ID: mdl-22411812
11.
Ordering a dynamic protein via a small-molecule stabilizer.
J Am Chem Soc
; 135(9): 3363-6, 2013 Mar 06.
Artigo
Inglês
| MEDLINE | ID: mdl-23384013
12.
Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia.
J Med Chem
; 66(4): 2717-2743, 2023 02 23.
Artigo
Inglês
| MEDLINE | ID: mdl-36735833
13.
A structure-based mechanism for displacement of the HEXIM adapter from 7SK small nuclear RNA.
Commun Biol
; 5(1): 819, 2022 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-35970937
14.
SD-91 as A Potent and Selective STAT3 Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression.
ACS Med Chem Lett
; 12(6): 996-1004, 2021 Jun 10.
Artigo
Inglês
| MEDLINE | ID: mdl-34141084
15.
Lipid-based vaccine nanoparticles for induction of humoral immune responses against HIV-1 and SARS-CoV-2.
J Control Release
; 330: 529-539, 2021 02 10.
Artigo
Inglês
| MEDLINE | ID: mdl-33358977
16.
Targeted disruption of pi-pi stacking in Malaysian banana lectin reduces mitogenicity while preserving antiviral activity.
Sci Rep
; 11(1): 656, 2021 01 12.
Artigo
Inglês
| MEDLINE | ID: mdl-33436903
17.
Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins.
J Med Chem
; 63(5): 2489-2510, 2020 03 12.
Artigo
Inglês
| MEDLINE | ID: mdl-31971799
18.
A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo.
Cancer Cell
; 36(5): 498-511.e17, 2019 11 11.
Artigo
Inglês
| MEDLINE | ID: mdl-31715132
19.
Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein.
J Med Chem
; 62(24): 11280-11300, 2019 12 26.
Artigo
Inglês
| MEDLINE | ID: mdl-31747516
20.
Interaction of a cyclic, bivalent smac mimetic with the x-linked inhibitor of apoptosis protein.
Biochemistry
; 47(37): 9811-24, 2008 Sep 16.
Artigo
Inglês
| MEDLINE | ID: mdl-18717598