Detalhe da pesquisa
1.
Prodrugs as empowering tools in drug discovery and development: recent strategic applications of drug delivery solutions to mitigate challenges associated with lead compounds and drug candidates.
Chem Soc Rev
; 53(4): 2099-2210, 2024 Feb 19.
Artigo
Inglês
| MEDLINE | ID: mdl-38226865
2.
The discovery and evaluation of [18F]BMS-986229, a novel macrocyclic peptide PET radioligand for the measurement of PD-L1 expression and in-vivo PD-L1 target engagement.
Eur J Nucl Med Mol Imaging
; 51(4): 978-990, 2024 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-38049658
3.
Challenges with the Synthesis of a Macrocyclic Thioether Peptide: From Milligram to Multigram Using Solid Phase Peptide Synthesis (SPPS).
J Org Chem
; 89(10): 6639-6650, 2024 May 17.
Artigo
Inglês
| MEDLINE | ID: mdl-38651358
4.
The pyridazine heterocycle in molecular recognition and drug discovery.
Med Chem Res
; : 1-69, 2023 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37362319
5.
GSK3640254 Is a Novel HIV-1 Maturation Inhibitor with an Optimized Virology Profile.
Antimicrob Agents Chemother
; 66(1): e0187621, 2022 01 18.
Artigo
Inglês
| MEDLINE | ID: mdl-34780263
6.
Electrophilic Hydrazination of Cyclopropanols Using Azodicarboxylates via Copper(II) Catalysis: An Umpolung Strategy to Access ß-Hydrazino Ketone Motifs.
J Org Chem
; 87(21): 14596-14608, 2022 11 04.
Artigo
Inglês
| MEDLINE | ID: mdl-36190309
7.
Synthetic Access to α-Oxoketene Aminals by the Nucleophilic Addition of Enol Silane-Derived Palladium(II) Enolates to Carbodiimides.
J Org Chem
; 87(21): 14778-14792, 2022 11 04.
Artigo
Inglês
| MEDLINE | ID: mdl-36285601
8.
Pseudoprolines as stereoelectronically tunable proline isosteres.
Bioorg Med Chem Lett
; 75: 128983, 2022 11 01.
Artigo
Inglês
| MEDLINE | ID: mdl-36096342
9.
Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyridinyl class of HIV-1 allosteric integrase inhibitors.
Bioorg Med Chem
; 67: 116833, 2022 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-35605346
10.
The Genesis and Future Prospects of Small Molecule HIV-1 Attachment Inhibitors.
Adv Exp Med Biol
; 1366: 45-64, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-35412134
11.
Ligand-Enabled ß-C(sp3 )-H Lactamization of Tosyl-Protected Aliphatic Amides Using a Practical Oxidant.
Angew Chem Int Ed Engl
; 61(34): e202207354, 2022 08 22.
Artigo
Inglês
| MEDLINE | ID: mdl-35790471
12.
Photocatalytic Dearomative Intermolecular [2 + 2] Cycloaddition of Heterocycles for Building Molecular Complexity.
J Org Chem
; 86(2): 1730-1747, 2021 01 15.
Artigo
Inglês
| MEDLINE | ID: mdl-33356273
13.
Design and exploration of C-3 benzoic acid bioisosteres and alkyl replacements in the context of GSK3532795 (BMS-955176) that exhibit broad spectrum HIV-1 maturation inhibition.
Bioorg Med Chem Lett
; 36: 127823, 2021 03 15.
Artigo
Inglês
| MEDLINE | ID: mdl-33508465
14.
Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A.
Nature
; 527(7577): 245-8, 2015 Nov 12.
Artigo
Inglês
| MEDLINE | ID: mdl-26536115
15.
Innovation in the discovery of the HIV-1 attachment inhibitor temsavir and its phosphonooxymethyl prodrug fostemsavir.
Med Chem Res
; 30(11): 1955-1980, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-34602806
16.
Synthesis of Cyclobutane-Fused Tetracyclic Scaffolds via Visible-Light Photocatalysis for Building Molecular Complexity.
J Am Chem Soc
; 142(6): 3094-3103, 2020 02 12.
Artigo
Inglês
| MEDLINE | ID: mdl-31927959
17.
Tailor-Made Amino Acids and Fluorinated Motifs as Prominent Traits in Modern Pharmaceuticals.
Chemistry
; 26(50): 11349-11390, 2020 Sep 04.
Artigo
Inglês
| MEDLINE | ID: mdl-32359086
18.
Design, synthesis and SAR study of novel C2-pyrazolopyrimidine amides and amide isosteres as allosteric integrase inhibitors.
Bioorg Med Chem Lett
; 30(21): 127516, 2020 11 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32860982
19.
Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors.
Bioorg Med Chem Lett
; 30(3): 126784, 2020 02 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31761656
20.
Structure-based amelioration of PXR transactivation in a novel series of macrocyclic allosteric inhibitors of HIV-1 integrase.
Bioorg Med Chem Lett
; 30(22): 127531, 2020 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-32890685