RESUMO
Malaria and typhoid co-infections can be a serious public health issue in tropical countries leading to incorrect diagnosis due to overlapping clinical presentations of malaria and typhoid and hence, causing a delay in implementing the appropriate treatment regimen for these concurrent infections. This study reports a case of six-year-old female child co-infected with severe malaria (Plasmodium falciparum) and typhoid (Salmonella typhi) diagnosed by rapid malaria antigen test (RMAT) and blood culture respectively. Further, analysis of the chloroquine resistance gene Pfcrt for the falciparum demonstrated the presence of K76T mutant allele in pfcrt gene with high IC50 (150nM) for chloroquine (CQ) drug. The present case highlights the significance of timely identification and treatment of co-infections and also provides information about the circulating P. falciparum clinical strains.
Assuntos
Antimaláricos , Coinfecção , Malária Falciparum , Malária , Febre Tifoide , Antimaláricos/farmacologia , Antimaláricos/uso terapêutico , Criança , Cloroquina/uso terapêutico , Coinfecção/diagnóstico , Resistência a Medicamentos/genética , Feminino , Humanos , Malária/tratamento farmacológico , Malária Falciparum/complicações , Malária Falciparum/diagnóstico , Malária Falciparum/tratamento farmacológico , Proteínas de Membrana Transportadoras/genética , Proteínas de Membrana Transportadoras/uso terapêutico , Plasmodium falciparum/genética , Proteínas de Protozoários/genética , Febre Tifoide/complicações , Febre Tifoide/diagnóstico , Febre Tifoide/tratamento farmacológicoRESUMO
A 3-year-old boy presented with recurrent strokes and pallor. Hematological investigations revealed severe iron deficiency anemia without thrombocytosis. The magnetic resonance angiogragraphy findings were suggestive of moyamoya syndrome. The association of moyamoya syndrome with severe iron deficiency anemia has not been reported earlier. The likely pathophysiological mechanisms are discussed.
Assuntos
Anemia Ferropriva/complicações , Anemia Ferropriva/fisiopatologia , Doença de Moyamoya/etiologia , Doença de Moyamoya/fisiopatologia , Anemia Ferropriva/diagnóstico por imagem , Pré-Escolar , Humanos , Angiografia por Ressonância Magnética , Masculino , Doença de Moyamoya/diagnóstico por imagem , RadiografiaRESUMO
Chikungunya virus is an RNA virus that belongs to the family Togaviridae, genus Alphavirus, transmitted by Aedes mosquitoes. The disease usually manifests as fever, arthralgia and petechial or maculopapular rash. The illness is usually self-limiting. We report a series of neonates infected with Chikungunya virus, confirmed by ELISA test, showing that viral Chikungunya can be transmitted from mother to babies and its clinical presentation is that of septicemia or meningitis.