Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros

Base de dados
Ano de publicação
Tipo de documento
Intervalo de ano de publicação
1.
Pharmeur Sci Notes ; 2006(1): 9-15, 2006 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-17694640

RESUMO

Thanks to the recent technological advancements, evaporative light-scattering detection (ELSD) is regarded as a valuable alternative to UV detection for liquid chromatographic analysis of substances that do not contain a chromophore. In the field of substances for pharmaceutical use, LC-ELSD appears to be suitable for aminoglycosides, most of which (for ex. gentamicin) are presently controlled in the Ph. Eur. by pulsed amperometric detection. Other substances (ex sugars, triglycerides) presently employing refractometrric detection, could be conveniently analysed by LC-ELSD. ELS detection is regarded as robust and relatively simple, although not particularly sensitive. A key feature of ELSD is that - unlike refractometry - it can operate in gradient mode, thus allowing application of more selective liquid chromatographic methods. ELSD can also be used to set up MS-compatible methods, as the mobile phase constraints are essentially the same. Due to all the above, ELSD is becoming increasingly used in pharmacopoeial methods.


Assuntos
Cromatografia Líquida/métodos , Preparações Farmacêuticas/análise , Espalhamento de Radiação , Aminoglicosídeos/análise , Carboidratos/análise , Contaminação de Medicamentos , Luz , Farmacopeias como Assunto , Controle de Qualidade , Reprodutibilidade dos Testes , Triglicerídeos/análise
SELEÇÃO DE REFERÊNCIAS
Detalhe da pesquisa