RESUMO
INTRODUCTION: Stem cells isolated from human dental pulp tissue are different from other sources of Mesenchymal stem cells because of their embryonic neural crest sources and neuro-trophic potential. These stem cells consist of dental pulp stem cells from human permanent teeth and stem cells from human exfoliated deciduous teeth. AIM: In this study, we survey the advantages and disadvantages of these stem cells with therapies attitude. MAIN TEXT: Stem cells from human exfoliated deciduous teeth with a high proliferation rate could distinguish into a wide types of cells. After stem cell banking appearance, stem cells from human exfoliated deciduous teeth can preserve and use for treatment, especially in regenerative medicine. But the crucial health hazards related to stem cell transplantation, such as immune rejection reactions and the interaction with other tissues, should not be neglected. CONCLUSION: Further experiments are required to approve the impact of these stem cells on different human disorders.
RESUMO
Streptococcus mutans is the main cariogenic pathogen in the oral cavity, considered to contribute toward oral diseases. S. mutans is predominantly entrapped in plaque biofilms. OBJECTIVES: In this study, we surveyed the antibacterial activity of natural compounds in terms of the biofilm production of S. mutans. MATERIAL AND METHODS: We extracted the studies related to natural compounds affected on S. mutans biofilm from different databases. RESULTS: Disruption of S. mutans viability in biofilms by a potent new pharmacological factor could inhibit and remove cavities. Various antibacterial agents are needed to destroy biofilms that remove both pathogens and commensal bacteria, and also exert inhibitory effects on many bacterial species. CONCLUSIONS: An effective therapeutic agent for dental caries has to be capable of removing pathogens and their biofilms. Specific virulence attributes of S. mutans exist; hence, natural compounds that have excellent properties to combat such pathogens need to be selected.