Increased vertebral morphometric fracture in patients with postsurgical hypoparathyroidism despite normal bone mineral density.

BACKGROUND: The mechanism behind parathyroid hormone (PTH) activation of bone remodeling is intimately dependent on the time of exposure of bone cells to hormone levels. Sustained high PTH levels trigger catabolism, while transitory elevations induce anabolism. The effects of hypoparathyroidism (PhPT) on bone are unknown. The objective was to study the impact of PhPT on bone mineral density (BMD), on the frequency of subclinical vertebral fracture and on mandible morphometry. METHODS: The study comprised thirty-three postmenopausal women, 17 controls (CG) and 16 with PhPT (PhPTG) matched for age, weight and height. Bone mineral density (BMD) of lumbar spine, total hip and 1/3 radius, radiographic evaluation of vertebral morphometry, panoramic radiography of the mandible, and biochemical evaluation of mineral metabolism and bone remodeling were evaluated in both groups. RESULTS: There were no significant differences in lumbar spine or total hip BMD between groups. There was marked heterogeneity of lumbar spine BMD in PhPTG (high = 4, normal = 9, osteopenia = 1, and osteoporosis = 2 patients). BMD was decreased in the 1/3 radius in PhPTG P < 0.005). The PhPTG group exhibited an increased frequency of morphometric vertebral fractures and decreased mandible cortical thickness. CONCLUSION: The study suggests that vertebral fragility occurs in PhPT despite normal or even high BMD. The current results encourage further studies to evaluate the use of panoramic radiography in the identification of osteometabolic disorders, such as PhPT and the development of a more physiological treatment for PhPT.

Characteristics of women diagnosed with mpox infection compared to men: A case series from Brazil.

BACKGROUND: Cisgender men were mostly affected during the 2022 mpox multinational outbreak, with few cases reported in women. This study compares the characteristics of individuals diagnosed with mpox infection according to gender in Rio de Janeiro. METHODS: We obtained surveillance data of mpox cases notified to Rio de Janeiro State Health Department (June 12 to December 15, 2022). We compared women (cisgender or transgender) to men (cisgender or transgender) using chi-squared, Fisher's exact, and Mood's median tests. RESULTS: A total of 1306 mpox cases were reported; 1188 (91.0%) men (99.8% cisgender, 0.2% transgender), 108 (8.3%) women (87.0% cisgender, 13.0% transgender), and 10 (0.8%) non-binary persons. Compared to men, women were more frequently older (40+years: 34.3% vs. 25.1%; p < 0.001), reported more frequent non-sexual contact with a potential mpox case (21.4% vs. 9.8%; p = 0.004), fewer sexual partnerships (10.9 vs. 54.8%; p < 0.001), less sexual contact with a potential mpox case (18.5% vs. 43.0%; p < 0.001), fewer genital lesions (31.8% vs. 57.9%; p < 0.001), fewer systemic mpox signs/symptoms (38.0% vs. 50.1%; p = 0.015) and had a lower HIV prevalence (8.3% vs. 46.3%; p < 0.001), with all cases among transgender women. Eight women were hospitalized; no deaths occurred. The highest number of cases among women were notified in epidemiological week 34, when the number of cases among men started to decrease. CONCLUSIONS: Women diagnosed with mpox presented differences in epidemiological, behavioral, and clinical characteristics compared to men. Health services should provide a comprehensive assessment that accounts for gender diversity.

Primary Hyperparathyroidism: The Influence of Bone Marrow Adipose Tissue on Bone Loss and of Osteocalcin on Insulin Resistance.

OBJECTIVES: Bone marrow adipose tissue has been associated with low bone mineral density. However, no data exist regarding marrow adipose tissue in primary hyperparathyroidism, a disorder associated with bone loss in conditions of high bone turnover. The objective of the present study was to investigate the relationship between marrow adipose tissue, bone mass and parathyroid hormone. The influence of osteocalcin on the homeostasis model assessment of insulin resistance was also evaluated. METHODS: This was a cross-sectional study conducted at a university hospital, involving 18 patients with primary hyperparathyroidism (PHPT) and 21 controls (CG). Bone mass was assessed by dual-energy x-ray absorptiometry and marrow adipose tissue was assessed by 1H magnetic resonance spectroscopy. The biochemical evaluation included the determination of parathyroid hormone, osteocalcin, glucose and insulin levels. RESULTS: A negative association was found between the bone mass at the 1/3 radius and parathyroid hormone levels (r = -0.69; p<0.01). Marrow adipose tissue was not significantly increased in patients (CG = 32.8±11.2% vs PHPT = 38.6±12%). The serum levels of osteocalcin were higher in patients (CG = 8.6±3.6 ng/mL vs PHPT = 36.5±38.4 ng/mL; p<0.005), but no associations were observed between osteocalcin and insulin or between insulin and both marrow adipose tissue and bone mass. CONCLUSION: These results suggest that the increment of adipogenesis in the bone marrow microenvironment under conditions of high bone turnover due to primary hyperparathyroidism is limited. Despite the increased serum levels of osteocalcin due to primary hyperparathyroidism, these patients tend to have impaired insulin sensitivity.

Primary Hyperparathyroidism: The Influence of Bone Marrow Adipose Tissue on Bone Loss and of Osteocalcin on Insulin Resistance

OBJECTIVES: Bone marrow adipose tissue has been associated with low bone mineral density. However, no data exist regarding marrow adipose tissue in primary hyperparathyroidism, a disorder associated with bone loss in conditions of high bone turnover. The objective of the present study was to investigate the relationship between marrow adipose tissue, bone mass and parathyroid hormone. The influence of osteocalcin on the homeostasis model assessment of insulin resistance was also evaluated. METHODS: This was a cross-sectional study conducted at a university hospital, involving 18 patients with primary hyperparathyroidism (PHPT) and 21 controls (CG). Bone mass was assessed by dual-energy x-ray absorptiometry and marrow adipose tissue was assessed by 1H magnetic resonance spectroscopy. The biochemical evaluation included the determination of parathyroid hormone, osteocalcin, glucose and insulin levels. RESULTS: A negative association was found between the bone mass at the 1/3 radius and parathyroid hormone levels (r = -0.69; p<0.01). Marrow adipose tissue was not significantly increased in patients (CG = 32.8±11.2% vs PHPT = 38.6±12%). The serum levels of osteocalcin were higher in patients (CG = 8.6±3.6 ng/mL vs PHPT = 36.5±38.4 ng/mL; p<0.005), but no associations were observed between osteocalcin and insulin or between insulin and both marrow adipose tissue and bone mass. CONCLUSION: These results suggest that the increment of adipogenesis in the bone marrow microenvironment under conditions of high bone turnover due to primary hyperparathyroidism is limited. Despite the increased serum levels of osteocalcin due to primary hyperparathyroidism, these patients tend to have impaired insulin sensitivity.

Treatment of atrophic mandibular fracture related to implant placement in an oral bisphosphonate user: a case report / Tratamento de fratura em mandíbula atrófica com implantes em paciente usuário de bisfosfonato: umrelato de caso

Objectives: Atrophic mandibular fractures associated with placement of dental implants is an uncommon condition and to best of our knowledge this event in an oral bisphosphonate user was never described before. Case report: A 74-years-old woman presented a submandibular hematoma and mobility between two fragments on the right side of the body of the mandible after four implants placement. The patient reported the use of oralbisphosphonates for three years for treatment of osteoporosis. A titanium plate was placed at the base of the mandible to fix the fracture and the patient underwent a hyperbaric oxygen therapy for three months. Nine months after the surgery, the patient had no further complications and rehabilitation treatment was completed. Conclusions: The fracture fixation was effective in the treatment of atrophic mandibular fractures in an oral bisphosphonate user, with no occurrence of complications like osteonecrosis.In addition, the oral rehabilitation with prosthesisunder the remaining implants showed a satisfactory outcome.

Objetivo: Fraturas de mandíbula atrófica associadas à inserção de implantes é uma condição de ocorrência incomum e o objetivo desse relato de caso é descrever o tratamento de fratura de mandíbula atrófica associada à instalação de implantes em uma paciente usuária de bisfosfonato oral. Relato de caso: Paciente do sexo feminino com 74 anos apresentava presença de um hematoma submandibular e mobilidade entre dois fragmentos no corpo da mandíbula no lado direito após a instalação de 4 implantes. A paciente reportou uso de bisfosfonato por via oral a 3 anos para tratamento de osteoporose. A fratura foi reduzida e fixadacom uma placa de titânio na base da mandíbula e a paciente foi submetida a sessões de câmara hiperbárica por 3 meses. Após 9 meses do procedimento cirúrgico a paciente não apresentou complicações adicionais e o tratamento reabilitador foi finalizado. Conclusão: A fixação foi efetiva no tratamento da fratura em mandíbula atrófica em um paciente usuário de bisfosfonato oral e complicações com osteonecrose não foram detectadas. Adicionalmente, a reabilitação oral com próteses sobre implantes remanescente apresentaram um resultado satisfatório.

Indicações de ressonância magnética das mamas em um centro de referência em oncologia / Indications for breast magnetic resonance imaging in an oncology reference center

OBJETIVO: Avaliar e discutir as indicações de ressonância magnética das mamas em um centro de referência oncológico. MATERIAIS E MÉTODOS: Estudo retrospectivo, aprovado pelo Comitê de Ética e Pesquisa da instituição, conduzido através da revisão de prontuários e laudos médicos. Foram incluídos todos os exames de ressonância magnética das mamas realizados no período de julho de 2008 a julho de 2009 (n = 529). RESULTADOS: A idade média das pacientes foi de 49 anos, variando de 17 a 86 anos. História familiar de câncer de mama e/ou ovário esteve presente em 162 pacientes (30,6 por cento). As indicações mais comuns de ressonância magnética das mamas foram esclarecimento de achados inconclusivos na mamografia e/ou ultrassom (48,8 por cento), avaliação de recorrência tumoral/cicatriz cirúrgica (15,1 por cento), estadiamento/planejamento cirúrgico (11,7 por cento) e rastreamento de pacientes de alto risco (8,5 por cento). CONCLUSÃO: Apesar de achados inconclusivos nos exames convencionais serem a indicação mais comum de ressonância magnética das mamas, não há evidências que justifiquem esta conduta na literatura. Em razão da sua alta sensibilidade e percentual de falso-positivos, este exame deve ser adequadamente indicado, para evitar a realização de procedimentos desnecessários. Se bem indicada, a ressonância magnética pode contribuir para o processo de tomada de decisão e constitui uma ferramenta fundamental na avaliação de lesões mamárias.

OBJECTIVE: To evaluate and discuss the indications for breast magnetic resonance imaging in an oncology reference center. MATERIALS AND METHODS: Retrospective study approved by the Committee for Ethics in Research of the institution and developed through a review of patients' records and clinical reports. All the breast magnetic resonance studies performed in the period from July 2008 to July 2009 (n = 529) were included. RESULTS: Mean patients' age was 49 years, ranging from 17 to 86 years. Family history of breast and/or ovarian cancer was present in 162 patients (30.6 percent). Most common indications for breast magnetic resonance imaging included inconclusive mammographic/sonographic findings (48.8 percent), evaluation of tumor recurrence/surgical scar after breast surgery (15.1 percent), disease staging/surgical planning (11.7 percent) and screening in high-risk patients (8.5 percent). CONCLUSION: In spite of inconclusive findings at conventional imaging studies being the most common indication for breast magnetic resonance imaging, there is no evidence in the literature supporting such a conduct. Because of its high sensitivity and high rate of false positive results, magnetic resonance imaging should be appropriately indicated in order to avoid unnecessary procedures. Once such method is appropriately indicated, it may contribute in the decision making process, constituting an essential tool in the assessment of breast lesions.

Intrusão de molares com a utilização de placas de fixação rígida modificadas com carga imediata - relato de caso / Molar intrusion by using with rigid modified fixation plate com carga imediata - relate case

A intrusão é um tipo de movimento freqüentemente utilizado em Ortodontia. A intrusão isolada de um dente tem sido documentada com grande freqüência e aceita universalmente. Porém, quando necessitamos intuir molares, principalmente quando esses se encontram em extremos de arcos, as dificuldades aumentam devido a necessidade de ancoragem máxima. O objetivo deste trabalho foi avaliar, em dois casos clínicos, a intrusão de molares que sofreram extrusão fisiológica, utilizando-se implantes de placas de fixação rígida modificada e instalada no pilar zigomático da maxila, associada a barra transpalatina com braço de força, com intenção de criar um bom sistema de força de intrusão. Os resultados obtidos com a utilização de miniplacas de fixação e barra palatina com braço de força para o tratamento da intrusão foi de 3,5 mm no Caso I e de 4,O mm no Caso 2, conseguindo estes no período de três e quatro meses respectivamente.

Intrusion is a movement frequently used in orthodontics. The intrusion of a single tooth has been documented and is also accepted universally. However, when it is necessary to intrude molars. (generally when these are in extremos de arcos), the difficulties increase because of the need of maximum anchorage. The purpose of this paper was to evaluate, in two clinic cases, molar intrusion that suffered physiological extrusion by using with rigid modified fixation plate installed at zigomatic area of the maxillary bone, associated to a transpalatal arch with power arm, in order to create a good intrusion of forces. The obtained results from the utilization of rigid modified, fixation plate and transpalatal arch with power arm were 3,5 mmin the first Case and 4.0 mm in the second Case, in a period of three and four months, respectively.