1.
Eur J Med Chem
; 42(5): 702-14, 2007 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17316920
RESUMO
Based on the structure of R115777 (tipifarnib, Zarnestra), a series of farnesyltransferase inhibitors have been synthesized by modification of the 2-quinolinone motif and transposition of the 4-chlorophenyl ring to the imidazole or its replacement by 5-membered rings. This has yielded a novel series of potent farnesyltransferase inhibitors.