RESUMO
Optimizing pain management is a component of enhanced perioperative recovery for children undergoing urologic surgery. Incisional pain and discomfort from bladder spasms are two types of pain associated with bladder surgery. A child's developmental level and verbal skills must be considered when selecting pain assessment tools. Assessing pain location, type, and intensity is essential in developing a multimodal plan of care for post-operative pain. Pharmacological interventions provide effective pain management, which facilitates early ambulation, return to oral intake, and recovery. Pre-operative preparation, non-pharmacological interventions, and parental presence help decrease anxiety and promote comfort, as well as support a child's coping skills.
Assuntos
Enfermagem em Nefrologia , Manejo da Dor/enfermagem , Dor Pós-Operatória/enfermagem , Procedimentos Cirúrgicos Urológicos , Criança , HumanosRESUMO
The American Society for Pain Management Nursing (ASPMN) has updated its 2007 position statement on the use of authorized agent controlled analgesia (AACA) for patients who are unable to independently utilize patient-controlled analgesia (PCA). ASPMN continues to support the use of AACA to provide timely and effective pain management while promoting equitable care for vulnerable patient populations who are unable to utilize PCA. ASPMN does not support the use of "PCA by Proxy" in which unauthorized individuals activate PCA for a patient. The background of the development of the position statement, definitions related to AACA, and application of ethical principles to the use of AACA are presented in the document. This position statement includes an updated review of the evidence related to AACA and a call for further research. Clinical practice recommendations for authorized agents, nurses, prescribers, and organizations are provided with an emphasis on the importance of appropriate authorized agent selection, education, diligent patient assessment and medication management.
Assuntos
Analgesia Controlada pelo Paciente/normas , Manejo da Dor/normas , Dor/tratamento farmacológico , Dor/enfermagem , Guias de Prática Clínica como Assunto , Sociedades de Enfermagem , Analgésicos/uso terapêutico , Humanos , Manejo da Dor/enfermagemRESUMO
Individuals who are unable to communicate their pain are at greater risk for under recognition and undertreatment of pain. This position paper describes the magnitude of this issue, defines populations at risk and offers clinical practice recommendations for appropriate pain assessment using a hierarchical framework for assessing pain in those unable to self-report. Nurses have a moral, ethical, and professional obligation to advocate for all individuals in their care, particularly those who are vulnerable and unable to speak for themselves. Just like all other patients, these special populations require consistent, ongoing assessment, appropriate treatment, and evaluation of interventions to insure the best possible pain relief. Because of continued advances and new developments in strategies and tools for assessing pain in these populations, clinicians are encouraged to stay current through regular review of new research and practice recommendations.
Assuntos
Manejo da Dor , Dor/enfermagem , Guias de Prática Clínica como Assunto , Sociedades de Enfermagem/normas , Idoso , Pré-Escolar , Barreiras de Comunicação , Demência/enfermagem , Humanos , Lactente , Manejo da Dor/ética , Manejo da Dor/enfermagem , Manejo da Dor/normas , Autorrelato , Especialidades de Enfermagem/ética , Especialidades de Enfermagem/normasRESUMO
BACKGROUND: Blood draws are a routine element of the pediatric patient experience. They are also associated with the greatest fear and pain for a child. Because of the limited literature regarding phlebotomists' knowledge, experience, training, or stress related to their use of comfort techniques during pediatric blood draws, this study explored current practices and training methods. Phlebotomist training tends to focus on clinical technique rather than pediatric or patient comfort support. The study includes aims to develop a measurement for phlebotomists' use of comfort techniques for pediatric blood draws. METHOD: Focus groups of parent advocates (n = 24) and pediatric phlebotomists (n = 11) reviewed the survey questionnaire, and it was revised before being e-mailed to hospital system phlebotomists (n = 128). RESULTS: Almost half of the sample group lacked training in child development. The most frequently used comfort measures were words of explanation and reassurance, positioning of the child, and distraction. Requesting child life specialist support and using pain management devices or topical anesthetics were used less often. Primary challenges to performing pediatric blood draws were anxious patients and parents. CONCLUSION: Phlebotomists' use of available comfort measures occurs infrequently. Including child development and comfort techniques in training programs is essential to providing pediatric patients with a more satisfactory experience.
Assuntos
Conhecimentos, Atitudes e Prática em Saúde , Pessoal de Laboratório Médico/educação , Ferimentos Penetrantes Produzidos por Agulha/prevenção & controle , Manejo da Dor/métodos , Conforto do Paciente/estatística & dados numéricos , Satisfação do Paciente , Flebotomia/normas , Anestésicos Locais , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Pessoal de Laboratório Médico/normas , Pais/psicologia , Flebotomia/estatística & dados numéricosRESUMO
BACKGROUND: Difficulty assessing pain has been cited as one of the primary reasons for infrequent and inadequate assessment and analgesia for children with cognitive impairment (CI). Several behavioral observational pain tools have been shown to have good psychometric properties for pain assessment in this population; however, routine clinical use may depend largely on their pragmatic qualities. We designed this study to evaluate pragmatic attributes or clinical utility properties of three recently developed pain assessment tools for children with CI. METHODS: A sample of clinicians from three medical centers were asked to review 15 videotaped observations of children with CI, recorded during their first three postoperative days during participation in a previous study. Participants scored pain using the revised-Face, Legs, Activity, Cry, Consolability (r-FLACC) tool (individualized for the child during the previous study) for five observations, the noncommunicative Non-Communicating Children's Pain Checklist-Postoperative Version (NCCPC-PV) for five, and the Nursing Assessment of Pain Intensity (NAPI) for five observations. After their review of all segments, participants completed the Clinical Utility Attributes Questionnaire (CUAQ) ranking three attributes of clinical utility; complexity, compatibility, and relative advantage. RESULTS: Five physicians and 15 nurses comprised the sample. There was excellent agreement between the coded pain scores (i.e., mild, moderate, severe pain) assigned using all tools and r-FLACC scores assigned by original observers (88%-98% exact agreement; kappa 0.71-0.96). The internal consistency or reliability of the CUAQ was supported by high alpha values for each of the subscales (alpha = 0.84-0.93). Subscale and total CUAQ scores were higher for the r-FLACC and NAPI compared with the NCCPC-PV. The r-FLACC had similar scores for complexity, but slightly higher scores for compatibility, relative advantage, and total utility compared with the NAPI. CONCLUSIONS: We found that clinicians rated the complexity, compatibility, relative advantage, and overall clinical utility higher for the r-FLACC and NAPI compared with the NCCPC-PV, suggesting that these tools may be more readily adopted into clinical practice.
Assuntos
Comportamento Infantil , Transtornos Cognitivos/complicações , Medição da Dor/métodos , Dor Pós-Operatória/diagnóstico , Psicometria , Criança , Transtornos Cognitivos/psicologia , Estudos de Viabilidade , Humanos , Variações Dependentes do Observador , Dor Pós-Operatória/complicações , Dor Pós-Operatória/psicologia , Reprodutibilidade dos Testes , Índice de Gravidade de Doença , Inquéritos e Questionários , Estados Unidos , Gravação em VídeoRESUMO
The purpose of this study was to further test the validity of the Faces, Legs, Activity, Cry and Consolability (FLACC) Behavioral Pain Assessment Scale for use with children. Thirty children aged 3-7 years (5.01 +/- 1.44) who had undergone a variety of surgical procedures were observed and assessed for pain intensity at 20 + 2 hours after surgery. FLACC scores were assigned by one of the nurse investigators, and a self-report of pain using the FACES scale was obtained from the child. There were significant and positive correlations between the FLACC and FACES scores for the entire sample and for the scores of children 5-7 years of age, but not for children < age 5. These findings provide additional support for the construct validity of the FLACC Pain Assessment Tool.
Assuntos
Medição da Dor , Dor Pós-Operatória/diagnóstico , Criança , Pré-Escolar , Feminino , Indicadores Básicos de Saúde , Humanos , MasculinoRESUMO
BACKGROUND: Few investigators have evaluated pain assessment tools in the critical care setting. OBJECTIVE: To evaluate the reliability and validity of the Face, Legs, Activity, Cry, Consolability (FLACC) Behavioral Scale in assessing pain in critically ill adults and children unable to self-report pain. METHODS: Three nurses simultaneously, but independently, observed and scored pain behaviors twice in 29 critically ill adults and 8 children: before administration of an analgesic or during a painful procedure, and 15 to 30 minutes after the administration or procedure. Two nurses used the FLACC scale, the third used either the Checklist of Nonverbal Pain Indicators (for adults) or the COMFORT scale (for children). RESULTS: For 73 observations, FLACC scores correlated highly with the other 2 scores (rho = 0.963 and 0.849, respectively), supporting criterion validity. Significant decreases in FLACC scores after analgesia (or at rest) supported construct validity of the tool (mean, 5.27; SD, 2.3 vs mean, 0.52; SD, 1.1; P < .001). Exact agreement and kappa statistics, as well as intraclass correlation coefficients (0.67-0.95), support excellent interrater reliability of the tool. Internal consistency was excellent; the Cronbach alpha was 0.882 when all items were included. CONCLUSIONS: Although similar in content to other behavioral pain scales, the FLACC can be used across populations of patients and settings, and the scores are comparable to those of the commonly used 0-to-10 number rating scale.
Assuntos
Estado Terminal , Avaliação em Enfermagem/métodos , Medição da Dor/métodos , Medição da Dor/enfermagem , Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Choro , Expressão Facial , Feminino , Humanos , Lactente , Unidades de Terapia Intensiva , Masculino , Pessoa de Meia-Idade , Comunicação não Verbal , Observação , Reprodutibilidade dos Testes , Adulto JovemAssuntos
Medição da Dor/métodos , Analgésicos/uso terapêutico , Pré-Escolar , Dedos , Humanos , Lactente , Dor/tratamento farmacológicoAssuntos
Medição da Dor/métodos , Dor Pós-Operatória/diagnóstico , Analgesia/métodos , Analgesia/enfermagem , Criança , Comportamento Infantil , Pré-Escolar , Choro , Expressão Facial , Humanos , Lactente , Avaliação em Enfermagem/métodos , Medição da Dor/enfermagem , Medição da Dor/normas , Dor Pós-Operatória/fisiopatologia , Dor Pós-Operatória/psicologia , Psicologia da Criança , Índice de Gravidade de DoençaRESUMO
The American Society for Pain Management Nursing (ASPMN), in order to address sentinel alerts issued by JCAHO in 2004 and ISMP in 2005 concerning "PCA by Proxy", has developed a position statement and clinical practice recommendations on Authorized and Unauthorized (PCA by Proxy) Dosing of Analgesic Infusion Pumps, approved by the Board of Directors in June of 2006. In short, ASPMN does not support the use of "PCA by Proxy". ASPMN does, however, support the practice of Authorized Agent Controlled Analgesia in a variety of patient care settings when the agency has in place clear guidelines outlining the conditions under which this practice shall be implemented and outlining monitoring procedures that will insure safe use of the therapy. In addition to outlining this position, the paper clarifies and distinguishes between the unsafe practice of "PCA by Proxy", in which unauthorized individuals activate the dosing button of an analgesic infusion pump for a patient receiving Patient Controlled Analgesia, and the safe practice of Authorized Agent Controlled Analgesia (AACA). Furthermore, the paper examines the ethical and safety issues and outlines the necessary screening and patient/family education needed to implement AACA. The position statement describes criteria for the use of AACA, guidelines for selection and education of the authorized agent, key prescription and monitoring recommendations during therapy, and quality improvement activities to insure safety and effectiveness.
Assuntos
Analgesia Controlada pelo Paciente/normas , Cuidadores , Procurador , Analgesia Controlada pelo Paciente/ética , Analgesia Controlada pelo Paciente/enfermagem , Cuidadores/educação , Cuidadores/ética , Monitoramento de Medicamentos/enfermagem , Monitoramento de Medicamentos/normas , Família/psicologia , Humanos , Dor/tratamento farmacológico , Dor/enfermagem , Educação de Pacientes como Assunto/normas , Seleção de Pacientes , Ética Baseada em Princípios , Gestão da Segurança/normas , Gestão da Qualidade Total/normasRESUMO
BACKGROUND: Difficulty with pain assessment in individuals who cannot self-report their pain poses a significant barrier to effective pain management. However, available assessment tools lack consistent reliability as pain measures in children with cognitive impairment (CI). This study evaluated the validity and reliability of the revised and individualized Face Legs Activity Cry and Consolability (FLACC) behavioral pain assessment tool in children with CI. METHODS: Children with CI scheduled for elective surgery were studied. The FLACC was revised to include specific descriptors and parent-identified, unique behaviors for individual children. The child's ability to self-report pain was evaluated. Postoperatively, two nurses scored pain using the revised FLACC scale before and after analgesic administration, and, children self-reported a pain score, if able. Observations were videotaped and later viewed by experienced nurses blinded to analgesic administration. RESULTS: Eighty observations were recorded in 52 children aged 4-19 years. Twenty-one parents added individualized pain behaviors to the revised FLACC. Interrater reliability was supported by excellent intraclass correlation coefficients (ICC, ranging from 0.76 to 0.90) and adequate kappa statistics (0.44-0.57). Criterion validity was supported by the correlations between FLACC, parent, and child scores (rho = 0.65-0.87; P < 0.001). Construct validity was demonstrated by the decrease in FLACC scores following analgesic administration (6.1 +/- 2.6 vs 1.9 +/- 2.7; P < 0.001). CONCLUSIONS: Findings support the reliability and validity of the FLACC as a measure of pain in children with CI.
Assuntos
Transtornos Cognitivos , Deficiências do Desenvolvimento , Medição da Dor/métodos , Adolescente , Adulto , Criança , Comportamento Infantil , Pré-Escolar , Choro , Expressão Facial , Humanos , Variações Dependentes do Observador , Reprodutibilidade dos TestesRESUMO
During endotoxemia, liver microcirculation disruption is characterized by a hypersensitivity to the constrictor effects of endothelin 1 (ET-1). The shift of ET-1-mediated effects toward vasoconstriction may result from depressed ET-1-mediated vasodilation through decreased ET-1-induced nitric oxide (NO) production. We have previously shown that lipopolysaccharide (LPS) pretreatment abrogates ET-1-induced endothelial nitric oxide synthase (eNOS) translocation, but its effects on eNOS activation are yet to be determined. Our aim was to assess the effects of LPS on ET-1-mediated eNOS activation in hepatic sinusoidal endothelial cells (SECs) and to investigate the molecular mechanisms involved. SECs were treated with LPS (100 ng/mL) for 6 hours followed by 30 minutes ET-1 (10 nmol/L) stimulation. LPS significantly inhibited ET-1-mediated eNOS activation. This inhibition was associated with upregulation of Caveolin-1 (CAV-1) and a shift in ET-1-mediated eNOS phosphorylation from an activation (Ser1177) to an inhibition (Thr495). LPS treatment has been shown to induce ET-1 expression and secretion from endothelial cells. We therefore investigated the role of endogenous ET-1 in the inhibition of ET-1 activation of eNOS after LPS. Antagonizing ET-1 effects and blocking its activation in LPS pretreated SECs decreased the LPS-induced overexpression of CAV-1 as well as the inhibition of ET-1-induced NOS activity. Furthermore, 6 hours of ET-1 treatment exerted the same effects on eNOS activity, phosphorylation, and CAV-1 expression as LPS treatment. In conclusion, LPS-induced suppression of ET-1-mediated eNOS activation is ET-1 dependent and suggest a pivotal role of CAV-1 in eNOS induction inhibition under stress.
Assuntos
Caveolina 1/fisiologia , Endotelina-1/antagonistas & inibidores , Lipopolissacarídeos/farmacologia , Fígado/enzimologia , Óxido Nítrico Sintase Tipo III/metabolismo , Animais , Caveolina 1/análise , Endotelina-1/farmacologia , Ativação Enzimática/efeitos dos fármacos , Retroalimentação , Fígado/citologia , Masculino , Fosforilação , Ratos , Ratos Sprague-DawleyRESUMO
The article presents the position statement and clinical practice recommendations for pain assessment in the nonverbal patient developed by an appointed Task Force and approved by the ASPMN Board of Directors.
Assuntos
Barreiras de Comunicação , Transtornos da Comunicação/enfermagem , Comunicação não Verbal , Avaliação em Enfermagem/normas , Medição da Dor/normas , Fatores Etários , Idoso , Códigos de Ética , Transtornos da Comunicação/etiologia , Demência/complicações , Humanos , Lactente , Recém-Nascido , Intubação Intratraqueal/efeitos adversos , Papel do Profissional de Enfermagem , Avaliação em Enfermagem/ética , Avaliação em Enfermagem/métodos , Medição da Dor/ética , Medição da Dor/métodos , Medição da Dor/enfermagem , Defesa do Paciente/ética , Ética Baseada em Princípios , Inconsciência/complicaçõesRESUMO
OBJECTIVE: The objectives of this study were to develop a model for studying endothelin-1-mediated eNOS regulation in cultured sinusoidal endothelial cells and determine the effect of endothelin-1 and endotoxin (LPS) on eNOS localization. METHODS: Changes in caveolin-1, calmodulin, and eNOS expression were determined by western blot and densitometric analysis. Endothelin receptor expression and localization and the intracellular localization of eNOS and caveolin-1 were assessed by confocal microscopy. RESULTS: Sinusoidal endothelial cells expressed caveolin-1 and calmodulin, and expression was altered in cultured and passaged cells. eNOS expression decreased significantly in 24-h cultured cells, with expression dropping below the level of detection in passaged cells. Both endothelin A and endothelin B receptors were expressed on the cell surface after 24 h in culture. In 24-h cultured cells, caveolin-1 was localized in the perinuclear region and cell membrane, while eNOS was predominantly localized in the perinuclear region, where it co-localized with caveolin-1. Endothelin-1 stimulated eNOS translocation to the cell membrane. Pretreatment with LPS markedly inhibited the endothelin-1-mediated eNOS translocation. CONCLUSIONS: These studies demonstrate an LPS-mediated uncoupling of endothelin receptor activation and eNOS translocation. This functional uncoupling may, in part, account for the hyperconstrictive effects of endothelin-1 during inflammatory conditions.
Assuntos
Endotelina-1/metabolismo , Endotélio Vascular/citologia , Lipopolissacarídeos/farmacologia , Óxido Nítrico Sintase/metabolismo , Animais , Membrana Celular/metabolismo , Células Cultivadas , Células Endoteliais/efeitos dos fármacos , Células Endoteliais/metabolismo , Endotelina-1/fisiologia , Inflamação , Circulação Hepática , Masculino , Óxido Nítrico Sintase/análise , Óxido Nítrico Sintase Tipo III , Transporte Proteico/efeitos dos fármacos , Ratos , Ratos Sprague-Dawley , VasoconstriçãoRESUMO
Difficulties assessing pain in individuals who cannot use self-report scales has led to their exclusion from clinical trials and rendered them vulnerable to undertreatment of pain. Although several observational pain scales are available for use in these populations, many lack the characteristics necessary for routine implementation into practice or research. The Face, Legs, Activity, Cry And Consolability pain scale was developed as a simple measure of pain intensity in young children. It has been validated in the postoperative setting in children 2-7 years of age and children aged 4-18 years with varying degrees of cognitive impairment. With minor revisions, the Face, Legs, Activity, Cry and Consolability pain scale may be useful to assess acute pain across populations of children and adults who are unable to self-report their pain.
RESUMO
PURPOSE: To determine if low-dose ketorolac would improve analgesia while minimizing unwanted side effects in adolescents following posterior spinal fusion (PSF). METHODS: A prospective randomized double-blind placebo-controlled trial assessed the analgesic effects of low-dose ketorolac following PSF. Thirty-five adolescents aged 11-17 yr were randomly assigned to receive placebo or 0.5 mg x kg(-1) ketorolac (maximum of 15 mg) six hourly postoperatively for 36 hr in conjunction with standard morphine patient controlled analgesia (PCA). Pain and sedation were assessed twice daily for the first three postoperative days (POD). The incidence of side effects related to both non-steroidal anti-inflammatory agents and opioids were recorded. RESULTS: Adolescents in the ketorolac group received an average dose of 0.2 mg x kg(-1) (average exposure 1.2 mg x kg(-1)), had lower pain scores on POD one and two (P < 0.05) and consumed less morphine in the postanesthesia care unit and on POD two. There was no difference in the incidence of pruritus, nausea, vomiting or constipation, but patients in the ketorolac group tolerated activity better on POD one (P < 0.05). There were no differences between groups with regard to postoperative blood loss or transfusion requirements. Fourteen patients were followed for two years and the incidence of curve progression, hardware failure or back pain at final follow-up was not different. CONCLUSION: Low-dose ketorolac in conjunction with morphine PCA improved the quality of analgesia and reduced morphine requirements following PSF compared to placebo without increasing the incidence of non-steroidal anti-inflammatory side effects.