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1.
Audiol Neurootol ; 26(4): 273-280, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33626543

RESUMO

BACKGROUND: In this study, optic coherence tomography (OCT) examination was performed to check whether there was any interaction between ophthalmic axonal structures in unilateral tinnitus patients, and the relationship between optic nerve thickness and cochlear nerve thickness was evaluated. OBJECTIVE: The aim of the study was to evaluate the relatioship between hearing loss, tinnitus, and nerve thicknesses. STUDY DESIGN: Prospective study. SETTING: Tertiary referral university hospital. PATIENTS: The study included 88 patients with unilateral tinnitus, for which no organic cause could be found in physical examination, psychiatric evaluation, or with imaging methods. Study groups were formed of the tinnitus side and control groups were formed of the healthy side as follows: Group 1 (Non-tinnitus side normal hearing values - n = 30), Group 2 (non-tinnitus side minimal hearing loss - n = 27), Group 3 (non-tinnitus side moderate hearing loss - n = 31), Group 4 (tinnitus side normal hearing values - n = 25), Group 5 (tinnitus side minimal hearing loss - n = 25), and Group 6 (tinnitus side moderate hearing loss - n = 38). INTERVENTION: Retinal nerve fiber layer (RNFL) thickness was evaluated with OCT, and the cochlear nerve cross-sectional area was evaluated with MRI. MAIN OUTCOME MEASURES: RNFL measurements were taken with OCT from the subfoveal area (RNFL-SF) and 1.5 mm temporal to the fovea (RNFL-T µm) and nasal (RNFL-N µm) sectors. On MRI, 3 measurements were taken along the nerve from the cerebellopontine angle as far as the internal auditory canal, and the mean value of these 3 measurements was calculated. RESULTS: When the groups were evaluated in respect of cochlear nerve thickness, a significant difference was seen between Group 1 and both the groups with hearing loss and the tinnitus groups. In the subgroup analysis, a statistically significant difference was determined between Group 1 and Groups 3, 4, 5, and 6 (p = 0.013, p = 0.003, p < 0.001, and p < 0.001, respectively). When the groups were evaluated in respect of the RNFL-SF (µm), RNFL-T (µm), and RNFL-N (µm) values, the differences were determined to be statistically significant (p < 0.001 for all). In the correlation analysis, a negative correlation was determined between hearing loss and cochlear nerve diameter (r: -0.184, p = 0.014), and RNFL-N (r: -0.272, p < 0.001) and between tinnitus and cochlear nerve diameter (r: -0.536, p < 0.001), and RNFL-T (r: -0.222, p < 0.009). CONCLUSION: The study results clearly showed a relationship between cochlear nerve fiber thickness and hearing loss and the severity of tinnitus in cases with unilateral tinnitus and that there could be neurodegenerative factors in the disease etiology. A similar relationship seen with the RNFL supports the study hypothesis.


Assuntos
Perda Auditiva , Disco Óptico , Zumbido , Nervo Coclear , Perda Auditiva/diagnóstico por imagem , Humanos , Fibras Nervosas , Estudos Prospectivos , Células Ganglionares da Retina , Zumbido/diagnóstico por imagem , Tomografia de Coerência Óptica
2.
Eur Arch Otorhinolaryngol ; 278(7): 2337-2346, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-33389005

RESUMO

PURPOSE: The aim of this study was to evaluate the relationship between preoperative patient expectation and postoperative patient expectation coverage rates and patient satisfaction. METHODS: 183 patients who underwent SRP for various reasons were divided into 6 groups according to surgical indication and the postoperative Rhinoplasty Outcome Evaluation Scale (ROE). The groups were evaluated in terms of preoperative expectation levels and postoperative expectation coverage rate. RESULTS: When the patients were evaluated in terms of preoperative expectation levels, a significant difference was determined between the patients who underwent surgery for cosmetic reasons (86.15 ± 8.61) and those with functional reasons (79.24 ± 6.62) (p < 0.001). Similarly, the lowest patient expectation coverage rates were in the patient group with cosmetic reasons for the operation. When patients were grouped according to the ROE scores in the postoperative period and surgical indication, expectation was higher in the groups that were not satisfied with the results (Groups 2, 4 and 6). The highest expectation levels among the groups were seen in the dissatisfied patients who had undergone surgery for cosmetic reasons (92.17 ± 4.96). A strong positive correlation was found between expectation coverage rates and patient satisfaction (r 0.907, p < 0.001). CONCLUSION: Determination and rationalization of the expectations of patients in the preoperative period is one of the factors that will increase the satisfaction of the patients about the surgical procedure.


Assuntos
Motivação , Rinoplastia , Humanos , Avaliação de Resultados em Cuidados de Saúde , Satisfação do Paciente , Estudos Prospectivos , Resultado do Tratamento
3.
J Craniofac Surg ; 32(3): 868-873, 2021 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-33038179

RESUMO

AIM: To evaluate the contribution to patient satisfaction of the newly reshaped topographic anatomy of the nose, demographic, and functional results in the postoperative period of septorhinoplasty surgery. METHOD: A total of 370 patients applied with open and closed septorhinoplasty techniques for various reasons were grouped according to the postoperative Rhinoplasty Outcome Evaluation (ROE) Scale results; Group 1 (open rhinoplasty satisfied group, ROE ≥12 points, n:194), Group 2 (open rhinoplasty dissatisfied group, ROE <12 points, n:23), Group 3 (closed rhinoplasty satisfied group, ROE ≥12 points, n:137), Group 4 (closed rhinoplasty dissatisfied group, ROE <12 points, n:16). The groups were evaluated in respect of the effect on patient satisfaction of functional and demographic variables and satisfaction with the topographic outcome of the nose. RESULTS: The effect of the topographic surgical results was evaluated on patient satisfaction. A correlation was determined between nasal topographic satisfaction and patient satisfaction (r:0.228, P = 0.009). In the subgroup analyses, the only factor among the topographic factors which had an effect on satisfaction was the nasal tip (r:0.187, P = 0.024). Although 30.7% (n:39) of patients dissatisfied with the surgery reported that they were not satisfied with the nasal base results, no correlation was determined between nasal base and satisfaction (r:0.091, P = 0.463). The strongest correlations of patient satisfaction were determined to be with subjective (NOSE score [r:0.530, P < 0.001]) and objective (high nasal resistance levels [r:0.579, P < 0.001]) functional results. CONCLUSION: The 2 basic components of postoperative satisfaction with SRP surgery were shown to be functional healing and cosmetic outcomes. Of the surgical topographic results, nasal tip and nasal base were the parts determined to require the most attention.


Assuntos
Rinoplastia , Demografia , Humanos , Septo Nasal/cirurgia , Nariz/cirurgia , Satisfação do Paciente , Período Pós-Operatório , Resultado do Tratamento
4.
Pacing Clin Electrophysiol ; 41(7): 762-766, 2018 07.
Artigo em Inglês | MEDLINE | ID: mdl-29726590

RESUMO

BACKGROUND: Ventricular arrhythmias are reported to be more common in patients with obstructive sleep apnea (OSA). Preliminary evidence showed such parameters regarding ventricular repolarization as Tp-e, Tp-e/QT, and Tp-e/QTc may be related with increased cardiac arrhythmias and even sudden cardiac death. The purpose of the present study was to evaluate ventricular repolarization during immediately preapnea period, apnea period, and postapnea hyperventilation period in patients with OSA. METHODS: A total of 59 patients who underwent polysomnography and were diagnosed with OSA between the years 2016-2017 in our hospital were included in our study. Of 59 patients (mean age: 52.51 ± 9.66), 28 were male and 31 were female. In all patients, Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio, together with some other parameters, were calculated. Categorical variables were expressed as proportion and continuous variables were expressed as mean ± standard deviation. Electrocardiogram calculations of interest were compared through preapnea, apnea, and postapnea periods using Friedman's test. RESULTS: Tp-e interval (85.6 ms [78.3-95.6], 98 ms [88.5-107.7], 91.2 ms [81-98.8], respectively; P < 0.001), Tp-e/QT ratio (0.219 [0.202-0.237], 0.242 [0.224-0.269], 0.233 [0.212-0.246], respectively; P < 0.001), and Tp-e/QTc ratio (0.210 [0.190-0.222], 0.233 [0.209-0.247], 0.212 [0.193-0.229], respectively; P < 0.001) were significantly increased during apnea period compared to the preapnea period and significantly decreased during postapnea hyperventilation period compared to the apnea period. CONCLUSION: Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio were shown to be increased during apnea period and decreased during postapnea hyperventilation period. Our findings may help explain cardiac arrhythmias and sudden death in OSA patients.


Assuntos
Eletrocardiografia , Ventrículos do Coração/fisiopatologia , Apneia Obstrutiva do Sono/fisiopatologia , Adulto , Apneia/fisiopatologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de Tempo
5.
J Pediatr Urol ; 20(4): 748.e1-748.e7, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-38880668

RESUMO

INTRODUCTION: Cryptorchidism is one of the most common congenital anomalies in male children, occurring in 2-5% of full-term male infants. Both genetic and environmental factors are observed to play a role in its etiology. A study conducted in Japan identified the AXIN1 gene as being associated with cryptorchidism. OBJECTIVE: We aimed to conduct a pilot study on AXIN1 gene polymorphism in Turkish children with cryptorchidism, and whether AXIN1 gene polymorphism is a risk factor for cryptorchidism. STUDY DESIGN: Between January 2023 and December 2023, we have planned a prospective controlled study including 84 boys operated for cryptorchidism as study group, and 96 boys operated for circumcision as control group. The remaining blood samples of preoperative laboratory tests in ethylenediamine tetraacetic acid (EDTA) tubes were kept at -20 Co freezer for genomic studies. Patient demographics, physical examination and operative findings were recorded, study patients were grouped according to testis localization. After collecting all samples, genomic DNA isolation procedure was done, and analysis of the 3 polymorphisms (rs12921862, rs1805105 and rs370681) of AXIN1 gene was performed using conventional Polymerase Chain Reaction Restriction Fragment Length Polymorphism (PCR-RFLP) method. Genotype and allele frequencies of each group was analyzed and compared. RESULTS: The most common location of cryptorchid testis was proximal inguinal (53%), followed by distal inguinal (25.3%), bilateral (13.3%), and intra-abdominal (8.4%). Regarding the 3 polymorphisms of AXIN1 gene, there was no significant difference between study and control groups, in terms of genotype and allele frequencies (P > 0.05). Eight haplotype blocks were estimated for 3 polymorphisms of AXIN1. However, no significant difference was observed between study and control groups regarding haplotype distributions (P > 0.05). In addition, the comparison of the localization of testis with AXIN1 gene polymorphism did not show any significant difference among cryptorchid testis groups (P > 0.05). DISCUSSION: The AXIN1 gene is located on chromosome 16p and its polymorphisms have been associated with various diseases. In a Chinese study, the rs370681 polymorphism was found to be associated with cryptorchidism. However, our results showed no association between the AXIN1 gene haplotypes for the studied polymorphisms and cryptorchidism. CONCLUSION: In this study we have investigated the AXIN1 gene polymorphism in Turkish children with cryptorchidism as a pilot study. Although we could not identify any difference as compared to control group, further research is necessary to uncover the underlying molecular mechanisms contributing to the development of cryptorchidism.


Assuntos
Proteína Axina , Criptorquidismo , Humanos , Masculino , Proteína Axina/genética , Criptorquidismo/genética , Projetos Piloto , Turquia/epidemiologia , Estudos Prospectivos , Pré-Escolar , Lactente , Criança , Polimorfismo Genético , Estudos de Casos e Controles
6.
J Craniofac Surg ; 24(4): e390-3, 2013 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-23851880

RESUMO

Angiofibromas (AFs) are benign, potentially local aggressive, and rich vascular neoplasms that originate from posterior lateral wall of the nasopharynx in adolescent males. However, they could be encountered in sites other than nasopharynx. The maxillary sinus is the most common location of extranasopahryngeal AFs. The nasal septum is an extremely rare location, and only 15 cases had been reported in literature. In this present case, an unusual extranasal AF originating from the anterior part of the nasal septum is reported with its clinical, laboratory, and treatment options and theories proposed to explain the origin of extranasopharyngeal AFs are discussed.


Assuntos
Angiofibroma/patologia , Angiofibroma/cirurgia , Septo Nasal/patologia , Septo Nasal/cirurgia , Neoplasias Nasais/patologia , Neoplasias Nasais/cirurgia , Adolescente , Angiofibroma/diagnóstico por imagem , Diagnóstico Diferencial , Humanos , Imuno-Histoquímica , Masculino , Septo Nasal/diagnóstico por imagem , Neoplasias Nasais/diagnóstico por imagem , Tomografia Computadorizada por Raios X
7.
Front Neurosci ; 15: 625473, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33828445

RESUMO

Group analysis in diffusion tensor imaging is challenging. Comparisons of tensor morphology across groups have typically been performed on scalar measures of diffusivity, such as fractional anisotropy (FA), disregarding the complex three-dimensional morphologies of diffusion tensors. Scalar measures consider only the magnitude of the diffusion but not directions. In the present study, we have introduced a new approach based on directional statistics to use directional information of diffusion tensors in statistical group analysis based on Bingham distribution. We have investigated different directional statistical models to find the best fit. During the experiments, we confirmed that carrying out directional statistical analysis along the tract is much more effective than voxel- or skeleton-guided directional statistics. Hence, we propose a new method called tract profiling and directional statistics (TPDS) applicable to fiber bundles. As a case study, the method has been applied to identify connectivity differences of patients with major depressive disorder. The results obtained with the directional statistic-based analysis are consistent with those of NBS, but additionally, we found significant changes in the right hemisphere striatum, ACC, and prefrontal, parietal, temporal, and occipital connections as well as left hemispheric differences in the limbic areas such as the thalamus, amygdala, and hippocampus. The results are also evaluated with respect to fiber lengths. Comparison with the output of the network-based statistical toolbox indicated that the benefit of the proposed method becomes much more distinctive as the tract length increases. The likelihood of finding clusters of voxels that differ in long tracts is higher in TPDS, while that relationship is not clearly established in NBS.

8.
Cranio ; : 1-8, 2021 Mar 09.
Artigo em Inglês | MEDLINE | ID: mdl-33689596

RESUMO

Objective: To evaluate the relationship between obstructive sleep apnea syndrome (OSAS) and the fluid change in composition throughout the night.Methods: The study included 92 non-obese patients who underwent polysomnography because of suspected OSAS. Weight and body composition analyses were applied using a Tanita DC-360 multi-frequency body composition analysis device.Results: In the correlation analyses between apnea/hypopnea index (AHI) values and independent variables, a positive relationship was determined with extracellular fluid shift (r: 0.381, p = 0.009) and change in neck circumference (r: 0.226, p = 0.031), and there was a negative relationship between disease severity and an increase in the number of daily steps taken (r: 0.208, p = 0.047).Conclusion: The results of the study clearly showed that movement to the neck area of fluid accumulated in the lower extremities and an increase in extracellular fluid were related to AHI values independent of body mass index (BMI).

9.
Acta Cir Bras ; 35(8): e202000804, 2020 Sep 07.
Artigo em Inglês | MEDLINE | ID: mdl-32901681

RESUMO

PURPOSE: To investigate the effect of probiotics on spontaneous contractions of smooth muscle isolated from jejunum and ileum of rat model. METHODS: Four rat groups were created (n=8, in each) including control (Group 1), control+probiotic (Group 2), short bowel (Group 3), and short bowel+probiotic (Group 4). Groups 1 and 2 underwent sham operation, Groups 3 and 4 underwent massive bowel resection. Bifidobacterium Lactis was administered in Groups 2 and 4 daily (P.O.) for three weeks. On postoperative week 3, rats were sacrificed, and jejunum and ileum smooth muscle were isolated for organ bath. Muscle contraction changes were analyzed before and after addition of antagonists. RESULTS: Short bowel group exhibited increased amplitude and frequency of spontaneous contractions. The addition of probiotics significantly decreased enhanced amplitude and frequency of bowel contraction in short bowel group and returned to control values. L-NNA increased amplitude and frequency of contractions in all groups. While indomethacin and nimesulide increased the amplitude in all groups, the frequency was only increased in jejunum. Hexamethonium and tetrodotoxin did not change the contraction characteristics in all groups. CONCLUSION: We suggest that early use of probiotics may significantly regulate bowel motility, and accordingly improve absorption of nutrients in short bowel syndrome.


Assuntos
Motilidade Gastrointestinal , Probióticos , Síndrome do Intestino Curto , Animais , Motilidade Gastrointestinal/efeitos dos fármacos , Jejuno , Músculo Liso , Probióticos/farmacologia , Ratos
10.
Med Ultrason ; 21(3): 225-231, 2019 Aug 31.
Artigo em Inglês | MEDLINE | ID: mdl-31476200

RESUMO

AIMS: Hyperechoic/echo-rich periportal cuffing (ErPC) is defined as an increase in echogenicity relative to the adjacentliver parenchyma. Thickening in the periportal area may occur with proliferation of bile ducts, hemorrhage, oedema, fibrosis,inflammatory changes or a combination of these. The aim of this study is to determine which intraabdominal inflammatory diseases are associated with the presence of ErPC in the pediatric population and to calculate the sensitivity and specificity of this finding. MATERIAL AND METHODS: In this prospective study 200 consecutive children who underwent abdominal ultrasonography (US) were included: group 1, the patient group (100 children with appendicitis, gastroenteritis, mesenteric lymphadenitis, intestinal infection, terminal ileitis and invagination as cause of intra-abdominal inflammation) and group 2, the control group (100 children). RESULTS: The ErPC was positive in 74 (74%) cases in the patient group and in 3 (3%) in the control group. According to final diagnoses, we found ErPC in most of patients with gastroenteritis (16/17), perforated appendicitis (10/11), mesenteric lymphadenitis (5/6) and acute appendicitis (27/37). The sensitivity of ErPC in indicating intra-abdominal inflammation was 0.80 and its specificity was 0.87. No significant correlation between ErPC and age, gender and CRP was found but a moderate and significant positive correlation between ErPC and WBC (p=0,010; r=0.255) was detected. Very good concordance between observers in terms of the presence of ErPC on abdominal US was found (concordance 97% and kappa 0.93). CONCLUSIONS: We consider that the presence of ErPC in pediatric patients, when evaluated alongside clinical and laboratory findings, has a high sensitivity and specificity for inflammatory intra-abdominal pathology.


Assuntos
Gastroenteropatias/complicações , Gastroenteropatias/diagnóstico por imagem , Inflamação/complicações , Inflamação/diagnóstico por imagem , Fígado/diagnóstico por imagem , Ultrassonografia/métodos , Abdome/diagnóstico por imagem , Abdome/fisiopatologia , Adolescente , Criança , Pré-Escolar , Diagnóstico Diferencial , Feminino , Gastroenteropatias/fisiopatologia , Humanos , Inflamação/fisiopatologia , Fígado/fisiopatologia , Masculino , Estudos Prospectivos , Sensibilidade e Especificidade
11.
Case Rep Surg ; 2018: 5961913, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29808156

RESUMO

Cutaneous ciliated cyst is defined as a rare, painless lesion frequently encountered on the lower extremities of young girls after puberty. The cyst is surrounded by the columnar ciliary epithelium. Apart from the lower extremities of girls, they may be localized on the scalp, scapula, thumb, abdomen, umbilicus, thigh, heel, knee, and gluteal region. There are two theories to explain this localization. The first is that they are mullerian heterotrophy, while the other is that they are ciliated metaplasia of eccrine glands. In this paper, we described a cutaneous ciliated cyst, which was observed with a previously undescribed localization on the back of a 13-year-old female patient.

12.
Sportis (A Coruña) ; 8(3): 348-369, Sept. 2022. tab
Artigo em Inglês | IBECS (Espanha) | ID: ibc-207907

RESUMO

Los comportamientos de liderazgo de los capitanes de equipo en los deportes y la evaluación de los niveles de comunicación efectiva en términos de variables demográficas es el objetivo de estudio. La muestra del estudio está formada por 106 futbolistas que juegan al fútbol de forma activa en la 3ªLiga de la Federación Turca de Fútbol (TFF). Para la evaluación se ha utilizado la prueba de Kolmogorov-Smirnov, la prueba U de Mann Whitney, la prueba H de Kruskal Wallis y los análisis de correlación de Spearman. Los resultados muestran que hubo una relación lineal positiva entre los comportamientos de liderazgo percibidos de los atletas y sus percepciones de comunicación efectiva. La diferencia significativa entre la variable nivel educativo, y el comportamiento democrático y el comportamiento autocrático, que son las subdimensiones de las percepciones de liderazgo en el deporte. La diferencia significativa entre la variable de posición y las subdimensiones de liderazgo en deportes, apoyo social y comportamiento gratificante. También hay una diferencia significativa entre el año jugando al fútbol y el comportamiento democrático, el apoyo social y el comportamiento gratificante. No se encontraron diferencias significativas entre las percepciones de comunicación efectiva y las variables demográficas. Cinco variables predictoras de las subdimensiones de liderazgo en los deportes explican significativamente aproximadamente el 30 % de la variación total en las puntuaciones de comunicación efectiva. Como resultado, se puede concluir que los comportamientos socialmente apoyados, gratificantes, educativos e instructivos de los capitanes de equipo aumentan sus habilidades de comunicación efectiva con sus atletas. (AU)


Leadership behaviors of team captains in sports and the evaluation of effective communication levels in terms of demographic variables is the aim for study. The sample of the study consists of 106 football players who play football actively in the 3rd League of the Turkish Football Federation (TFF). Kolmogorov-Smirnov test, Mann Whitney U test, Kruskal Wallis H test and Spearman correlation analyzes has been used for evaluating. The results show that there was a positive linear relationship between the perceived leadership behaviors of the athletes and their perceptions of effective communication. The significant difference between the education level variable, and the democratic behavior and autocratic behavior, which are the sub-dimensions of the perceptions of leadership in sports. The significant difference between the variable of position and the sub-dimensions of leadership in sports, social support and rewarding behavior. There is also a significant difference between the year playing football and democratic behavior, social support and rewarding behavior. No significant difference was found between perceptions of effective communication and demographic variables. Five predictor variables from the sub-dimensions of leadership in sports significantly explain approximately 30% of the total variance in effective communication scores. As a result, it can be concluded that the socially supported, rewarding, educational and instructive behaviors of team captains increase their effective communication skills with their athletes. (AU)


Assuntos
Humanos , Adulto Jovem , Adulto , Futebol , Atletas , Liderança , Turquia
13.
Int J Pediatr Otorhinolaryngol ; 89: 173-8, 2016 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-27619052

RESUMO

INTRODUCTION: Cisplatin ototoxicity is characterized by irreversible, progressive, bilateral sensorineural hearing loss at high frequencies, accompanied by tinnitus. The aim of this study is to demonstrate the protective action of curcumin alone or in combination with vitamin E against cisplatin-induced ototoxicity in animal models. MATERIAL AND METHODS: The study included 42 rats. Experimental animals were randomized into 6 groups. In the first group, intra-peritoneal cisplatin was administered alone. In the second group, intra-peritoneal cisplatin and curcumin were administered together. In the third group, intra-peritoneal cisplatin and vitamin E were administered together. In the fourth group, intra-peritoneal cisplatin was administered together with curcumin in combination with vitamin E. In the fifth group, intra-peritoneal curcumin was administered alone. The sixth group was sacrificed directly without administration of any drugs. A distortion product otoacoustic emission (DPOAE) test was applied to both ears of all experimental animals. Curcumin was administered 1 h before cisplatin treatment continued for three successive days. Vitamin E was administered only as a single dose 30 min prior to cisplatin. All animals were sacrificed following DPOAE testing on the 5th day of cisplatin administration. Histopathological findings included a TUNEL (TdT-mediated deoxyuridine triphosphate nick end-labeling) assay, and the percentage of apoptotic cells was calculated. DPOAE values and the percentage of apoptotic cells were compared before and after treatment and between experimental groups. RESULTS: In Group 1, DPOAE values were significantly decreased at all frequencies (3000 Hz, 4000 Hz and 6000 Hz; P < 0.05). In Groups 2, 3, 4 and 5 there was no significant difference between the pre- and post-treatment DPOAE results (p > 0.05). Apoptotic index values were lower in all treatment groups compared to the cisplatin group, however the difference was only statistically significant in group 3 (p = 0.009). CONCLUSION: In rats, cisplatin ototoxicity can be prevented with curcumin or curcumin-vitamin E combination.


Assuntos
Antineoplásicos/toxicidade , Cisplatino/toxicidade , Curcumina/farmacologia , Perda Auditiva Neurossensorial/tratamento farmacológico , Emissões Otoacústicas Espontâneas/efeitos dos fármacos , Vitamina E/farmacologia , Animais , Antioxidantes/farmacologia , Apoptose , Cisplatino/farmacologia , Corantes , Quimioterapia Combinada , Perda Auditiva Neurossensorial/induzido quimicamente , Injeções Intraperitoneais , Masculino , Órgão Espiral/efeitos dos fármacos , Órgão Espiral/patologia , Ratos , Ratos Wistar , Zumbido
14.
Acta cir. bras ; 35(8): e202000804, 2020. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1130666

RESUMO

Abstract Purpose To investigate the effect of probiotics on spontaneous contractions of smooth muscle isolated from jejunum and ileum of rat model. Methods Four rat groups were created (n=8, in each) including control (Group 1), control+probiotic (Group 2), short bowel (Group 3), and short bowel+probiotic (Group 4). Groups 1 and 2 underwent sham operation, Groups 3 and 4 underwent massive bowel resection. Bifidobacterium Lactis was administered in Groups 2 and 4 daily (P.O.) for three weeks. On postoperative week 3, rats were sacrificed, and jejunum and ileum smooth muscle were isolated for organ bath. Muscle contraction changes were analyzed before and after addition of antagonists. Results Short bowel group exhibited increased amplitude and frequency of spontaneous contractions. The addition of probiotics significantly decreased enhanced amplitude and frequency of bowel contraction in short bowel group and returned to control values. L-NNA increased amplitude and frequency of contractions in all groups. While indomethacin and nimesulide increased the amplitude in all groups, the frequency was only increased in jejunum. Hexamethonium and tetrodotoxin did not change the contraction characteristics in all groups. Conclusion We suggest that early use of probiotics may significantly regulate bowel motility, and accordingly improve absorption of nutrients in short bowel syndrome.


Assuntos
Animais , Ratos , Síndrome do Intestino Curto , Probióticos/farmacologia , Motilidade Gastrointestinal/efeitos dos fármacos , Jejuno , Músculo Liso
15.
Int J Otolaryngol ; 2014: 169123, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25374605

RESUMO

Purpose. This study was conducted with the aim of investigating the relationship between mastoid air cell volumes and graft success after tympanoplasty. Material and Methods. This study was performed retrospectively with patients undergoing type I tympanoplasty and antrostomy. A total of 57 patients (20-35.09% female and 37-64.91% male) with a mean age of 29.69 ± SD (range 12-56 years) were included in the study. The patients were invited for a control at the 1st, 3rd, and 12th months, and otoscopic examinations and audiometric tests were performed. The temporal bone computed tomography images were screened with the 4800 Dpi optic resolution scanner and transferred to the computer environment in JPG format in order to calculate the mastoid air cell volume, and the volumes were calculated using the Autocad 2007 program. Results. Although, the graft success was determined to be better in the well-ventilated group, no significant difference could be found between the groups in terms of graft success at the 1st, 3rd, and 12th months (P > 0.05). No statistically significant difference could be found between the three groups in terms of the preoperative and postoperative hearing gains (P > 0.05).

16.
J Cardiovasc Risk ; 9(4): 207-14, 2002 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-12394329

RESUMO

BACKGROUND: The measures of secondary prevention in patients undergoing coronary bypass graft surgery (CABG) remains largely undetermined in Turkey. DESIGN: We designed a multicentre cross-sectional study to estimate the prevalence of cardiovascular risk factors in patients after CABG and to evaluate the association of demographic-socio-economic factors with secondary prevention in these patients. METHODS: A total of 622 patients who underwent CABG between 1 January 1999 and 15 January 2000 at four centres in Adana, Turkey; 273 (ages 35-77, 208 men) were interviewed and examined 1.0-2.2 years after the procedure. RESULTS: Of 273 patients interviewed, 81.5% were overweight, 65.5% had unhealthy food choices for a lipid-lowering diet, 56.0% were physically inactive, 28.8% were obese and 17.6% were current smokers. Hypercholesterolaemia, elevated blood pressure and fasting blood glucose were found in 65.6, 34.1 and 19.8%, respectively. Of diabetic patients, 63.8% had elevated fasting blood glucose. The use of angiotensin-converting enzyme inhibitors, beta-blockers and statins was low. Women had a higher rate of obesity and physical inactivity; smoking was less prevalent in females. More women were taking antihypertensive and lipid-lowering drugs than men. Logistic regression analysis revealed an association between hypercholesterolaemia and low educational level. CONCLUSION: Turkish patients have a high prevalence of modifiable risk factors related to unhealthy lifestyle and ineffective prophylactic drug use 1 year or more after CABG. Low educational level has a significant influence in this situation.


Assuntos
Ponte de Artéria Coronária , Doença das Coronárias/epidemiologia , Comportamentos Relacionados com a Saúde , Adulto , Idoso , Fármacos Cardiovasculares/uso terapêutico , Ponte de Artéria Coronária/mortalidade , Doença das Coronárias/prevenção & controle , Doença das Coronárias/cirurgia , Estudos Transversais , Fatores Epidemiológicos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Fatores de Risco , Prevenção Secundária , Fatores Socioeconômicos , Turquia/epidemiologia , População Urbana
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