Detalhe da pesquisa
1.
Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model.
Bioorg Med Chem Lett
; 80: 129108, 2023 01 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36538993
2.
Human PLD structures enable drug design and characterization of isoenzyme selectivity.
Nat Chem Biol
; 16(4): 391-399, 2020 04.
Artigo
Inglês
| MEDLINE | ID: mdl-32042197
3.
Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors.
Bioorg Med Chem Lett
; 60: 128549, 2022 03 15.
Artigo
Inglês
| MEDLINE | ID: mdl-35041943
4.
Novel Structure and Unexpected RNA-Binding Ability of the C-Terminal Domain of Herpes Simplex Virus 1 Tegument Protein UL21.
J Virol
; 90(12): 5759-69, 2016 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27053559
5.
Corrigendum to "Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors" [Bioorg. Med. Chem. Lett. 60 (2022) 128549].
Bioorg Med Chem Lett
; 72: 128856, 2022 Sep 15.
Artigo
Inglês
| MEDLINE | ID: mdl-35728998
6.
The unusual fold of herpes simplex virus 1 UL21, a multifunctional tegument protein.
J Virol
; 89(5): 2979-84, 2015 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-25540382
7.
A monomeric uncleaved respiratory syncytial virus F antigen retains prefusion-specific neutralizing epitopes.
J Virol
; 88(20): 11802-10, 2014 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-25078705
8.
The Discovery of 7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)-N-(6-methylpyrazolo[1,5-a]pyrimidin-3-yl)imidazo[1,2-a]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke.
J Med Chem
; 67(6): 4676-4690, 2024 Mar 28.
Artigo
Inglês
| MEDLINE | ID: mdl-38467640
9.
A Tiny Pocket Packs a Punch: Leveraging Pyridones for the Discovery of CNS-Penetrant Aza-indazole IRAK4 Inhibitors.
ACS Med Chem Lett
; 15(5): 714-721, 2024 May 09.
Artigo
Inglês
| MEDLINE | ID: mdl-38746903
10.
Discovery of BIO-8169âA Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation.
J Med Chem
; 67(10): 8383-8395, 2024 May 23.
Artigo
Inglês
| MEDLINE | ID: mdl-38695469
11.
Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis.
J Med Chem
; 67(10): 8122-8140, 2024 May 23.
Artigo
Inglês
| MEDLINE | ID: mdl-38712838
12.
Erratum for Metrick and Heldwein, Novel Structure and Unexpected RNA-Binding Ability of the C-Terminal Domain of Herpes Simplex Virus 1 Tegument Protein UL21.
J Virol
; 90(15): 7007-7008, 2016 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27402813
13.
Discovery of Phospholipase D Inhibitors with Improved Drug-like Properties and Central Nervous System Penetrance.
ACS Med Chem Lett
; 13(4): 665-673, 2022 Apr 14.
Artigo
Inglês
| MEDLINE | ID: mdl-35450377
14.
Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis.
J Med Chem
; 65(2): 1206-1224, 2022 01 27.
Artigo
Inglês
| MEDLINE | ID: mdl-34734694
15.
Conserved Outer Tegument Component UL11 from Herpes Simplex Virus 1 Is an Intrinsically Disordered, RNA-Binding Protein.
mBio
; 11(3)2020 05 05.
Artigo
Inglês
| MEDLINE | ID: mdl-32371601
16.
Discovery of BIIB068: A Selective, Potent, Reversible Bruton's Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases.
J Med Chem
; 63(21): 12526-12541, 2020 11 12.
Artigo
Inglês
| MEDLINE | ID: mdl-32696648