Detalhe da pesquisa
1.
Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
J Med Chem
; 49(22): 6439-42, 2006 Nov 02.
Artigo
Inglês
| MEDLINE | ID: mdl-17064063
2.
Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors.
J Med Chem
; 49(12): 3520-35, 2006 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-16759095
3.
Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes.
J Med Chem
; 49(21): 6416-20, 2006 Oct 19.
Artigo
Inglês
| MEDLINE | ID: mdl-17034148
4.
Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo.
Mol Cancer Ther
; 4(6): 977-86, 2005 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-15956255
5.
Discovery and structure-activity relationship of oxalylarylaminobenzoic acids as inhibitors of protein tyrosine phosphatase 1B.
J Med Chem
; 46(11): 2093-103, 2003 May 22.
Artigo
Inglês
| MEDLINE | ID: mdl-12747781
6.
Development of insulin resistance and endothelin-1 levels in the Zucker fatty rat.
Metabolism
; 52(7): 845-9, 2003 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-12870159
7.
Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit.
Bioorg Med Chem Lett
; 17(7): 2005-12, 2007 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-17276063