Four novel insecticidal sesquiterpene esters from Celastrus angulatus.

Four new insecticidal sesquiterpene polyol esters with a beta-dihydroagarofuran sesquiterpene skeleton, celangulatin C (1), celangulatin D (2), celangulatin E (3), and celangulatin F (4), and five known compounds 5-9 were isolated from the low-polar toluene extracts of the root bark of Celastrus angulatus by bioassay-guided fractionation. Their chemical structures were elucidated mainly by analyses of MS and NMR spectral data. Celangulatin C, E and F showed LD(50) against Mythimna separata were 280.4, 1656.4 and 210.5 microg mL(-1), respectively.

Two new insecticidal sesquiterpene polyol esters from Celastrus angulatus.

Two new insecticidal sesquiterpene polyol esters with a beta-dihydroagarofuran sesquiterpene skeleton, celangulatin A (1), B (2), and two known compounds, celangulin IV (3) and V (4), were isolated from the leaves of Celastrus angulatus by bioassay-guided fractionation. Their chemical structures were elucidated mainly by analyses of the NMR and MS spectral data. Their insecticidal activities against Mythimna separate were demonstrated with the KD50 value of 68.5 and 215.8 microg g(-1), respectively.

Insecticidal sesquiterpene pyridine alkaloids from Euonymus species.

Three insecticidal sesquiterpene pyridine alkaloids with a beta-dihydroagarofuran sesquiterpene skeleton, euoverrine A (1), B (2), and euophelline (3), and a known compound, euojaponine C (4), were isolated from the root bark of Euonymus verrucosides, E. fortunei and E. phellomana by bioassay-guided fractionation. Their chemical structures were elucidated mainly by analyses NMR and MS spectral data.

Synthesis, photostability and bioactivity of 2,3-cyclopropanated abscisic acid.

The plant hormone abscisic acid (ABA) plays a central role in the regulation of plant development and adaptation to environmental stress. The isomerization of ABA to the biologically inactive 2E-isomer by light considerably limits its applications in agricultural fields. To overcome this shortcoming, an ABA analogue, cis-2,3-cyclopropanated ABA, was synthesized, and its photostability and biological activities were investigated. This compound showed high photostability under UV light exposure, which was 4-fold higher than that of (±)-ABA. cis-2,3-cyclopropanated ABA exhibited high ABA-like activity, including the ability to effectively inhibit seed germination, seedling growth and stomatal movements of Arabidopsis. In some cases, its bioactivity approaches that of (±)-ABA. trans-2,3-cyclopropanated abscisic acid was also prepared, an isomer that was more photostable but which showed weak ABA-like activity.

Three new insecticidal sesquiterpene pyridine alkaloids from Celastrus angulatus.

Three new sesquiterpene pyridine alkaloids with a beta-dihydroagarofuran sesquiterpene skeleton, celangulatin G(1), H(2) and I(3), and one known alkaloid 4 were isolated from the middle-polar extracts of the root bark of Celastrus angulatus by bioassay-guided separation. Their chemical structures were elucidated mainly by the analyses of the MS and NMR spectral data. Celangulatin G(1), H(2), I(3) and 4 showed KD(50) against Mythimna separata were 849.61, 80.24, 96.29 and 50.98 microg g(-1), respectively.

Epidural Anesthesia with 0.75% Ropivacaine in Cesarean Section / 中国医师杂志

Objective To compare the clinical efficacy and tolerability of 0 75% ropivacaine(8～10ml) versus 1% lidocaine plus 0 2% dicaine in epidural anesthesia cesarean section.Method Parturients for elective cesarean were randomly designed to receive 0 75% ropivacaine(groupⅠ,n=15) or 1%lidocaine plus 0 2% dicaine(groupⅡ,n=15) epidural anesthesia. Sensory block,intraoperative pain(VAS score) and abdominal wall relaxation were assessed together with adverse reaction. Results The percentage of sensory block to reach T6 level was higher in groupⅠ than that in groupⅡ(P

The influence of epimeric glycyrrhizic acid on production of endithelin-1 in lungs induced by ischemia-reperfusion injury in rabbits / 中华麻醉学杂志

Objective To evaluate the influence of epimeric glycyrrhizic acid on production of endothelin-1 (ET-1) in the lungs induced by ischemia-reperfusion(I/R) injury.Methods Twenty healthy long-ear white rabbits of both sexes, weighing 1.1-2.1kg were randomly divided into 2 groups: group I I/R alone ( n = 10) and group II I/R + epimeric glycyrrhizic acid (n = 10). The animals were anesthetized with thiopental 25 mg?kg-1 and tracheotomized and mechanically ventilated (FiO2 = 100% , VT = 10-13 ml?kg, RR = 20-30 bpm, I:E= 1: 1.2). Anesthesia was maintained with fentanyl, thiopental and vecuronium. Femoral artery was cannulated for continuous direct BP monitoring. MAP was maintained at 70-90 mm Hg during experiment. Right interval jugular vein was cannulated. Catheter was inserted into right atrium for fluid administration, blood sampling and right atrial pressure monitoring. Chest was opened and the hilum of right lung was mass-ligated to induce ischemia for 60 min and then released for reperfusion for 60 min. Epimeric glycyrrhizic acid 30 mg?kg-1 was given iv 30 min before ischemia of the right lung. Blood samples were taken from right atrium and femoral artery for determination of ET-1 concentration before ischemia of right lung (T0) and 1 and 5 min after right lung started being perfused (T1 , T2). At the end of 60 min reperfusion of the right lung, the animals were sacrificed and lungs (right and left) were removed for electron microscopic examination. Results In group 1 at T, the ET-1 levels in the blood from both femoral artery and right atrium were significantly higher than the baseline (T0) and the ET-1 concentration in the blood from femoral artery was significantly higher than that from right atrium. In group II there was no significant difference in blood ET-1 concentration between T0 and T, .Conclusion Ischemia-reperfusion induces increased production of ET-1 in the injured lung. Epimeric glycyrrhizic acid can inhibit the increase in the production of ET-1 in the induced by I/R.