Detalhe da pesquisa
1.
Discovery of novel indole derivatives as potent and selective inhibitors of proMMP-9 activation.
Bioorg Med Chem Lett
; 97: 129541, 2024 01 01.
Artigo
Inglês
| MEDLINE | ID: mdl-37952596
2.
Structural basis for the dual GTPase specificity of the DOCK10 guanine nucleotide exchange factor.
Biochem Biophys Res Commun
; 653: 12-20, 2023 04 23.
Artigo
Inglês
| MEDLINE | ID: mdl-36848820
3.
Novel bicyclic pyrazoles as potent ALK2 (R206H) inhibitors for the treatment of fibrodysplasia ossificans progressiva.
Bioorg Med Chem Lett
; 38: 127858, 2021 04 15.
Artigo
Inglês
| MEDLINE | ID: mdl-33609658
4.
Bis-Heteroaryl Pyrazoles: Identification of Orally Bioavailable Inhibitors of Activin Receptor-Like Kinase-2 (R206H).
Chem Pharm Bull (Tokyo)
; 67(3): 224-235, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-30828000
5.
Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms.
Proc Natl Acad Sci U S A
; 109(9): 3305-10, 2012 Feb 28.
Artigo
Inglês
| MEDLINE | ID: mdl-22331897
6.
Unique structure of ozoralizumab, a trivalent anti-TNFα NANOBODY® compound, offers the potential advantage of mitigating the risk of immune complex-induced inflammation.
Front Immunol
; 14: 1149874, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-37122706
7.
Targeting Ras-binding domain of ELMO1 by computational nanobody design.
Commun Biol
; 6(1): 284, 2023 03 17.
Artigo
Inglês
| MEDLINE | ID: mdl-36932164
8.
Identification of critical residues in G(alpha)13 for stimulation of p115RhoGEF activity and the structure of the G(alpha)13-p115RhoGEF regulator of G protein signaling homology (RH) domain complex.
J Biol Chem
; 286(23): 20625-36, 2011 Jun 10.
Artigo
Inglês
| MEDLINE | ID: mdl-21507947
9.
Crystal structure of human acetylcholinesterase in complex with tacrine: Implications for drug discovery.
Int J Biol Macromol
; 210: 172-181, 2022 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-35526766
10.
Reduced efficacy of a Src kinase inhibitor in crowded protein solution.
Nat Commun
; 12(1): 4099, 2021 07 02.
Artigo
Inglês
| MEDLINE | ID: mdl-34215742
11.
Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex.
Sci Adv
; 7(30)2021 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-34290093
12.
Structural Basis of Activin Receptor-Like Kinase 2 (R206H) Inhibition by Bis-heteroaryl Pyrazole-Based Inhibitors for the Treatment of Fibrodysplasia Ossificans Progressiva Identified by the Integration of Ligand-Based and Structure-Based Drug Design Approaches.
ACS Omega
; 5(20): 11411-11423, 2020 May 26.
Artigo
Inglês
| MEDLINE | ID: mdl-32478230
13.
Structural Basis for the Dual Substrate Specificity of DOCK7 Guanine Nucleotide Exchange Factor.
Structure
; 27(5): 741-748.e3, 2019 05 07.
Artigo
Inglês
| MEDLINE | ID: mdl-30853411
14.
Granzyme A Stimulates pDCs to Promote Adaptive Immunity via Induction of Type I IFN.
Front Immunol
; 10: 1450, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-31293597
15.
Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye.
Sci Signal
; 11(541)2018 07 31.
Artigo
Inglês
| MEDLINE | ID: mdl-30065028
16.
Preferential recognition of isocitrate dehydrogenase by a rabbit monoclonal antibody (ab124797) against the C-terminal peptide of RANKL.
J Immunol Methods
; 420: 1-10, 2015 May.
Artigo
Inglês
| MEDLINE | ID: mdl-25771969
17.
Tetrameric interaction of the ectoenzyme CD38 on the cell surface enables its catalytic and raft-association activities.
Structure
; 20(9): 1585-95, 2012 Sep 05.
Artigo
Inglês
| MEDLINE | ID: mdl-22863568