[Actual problems of cardiovascular risk in urban population of Ukrain].

AIM: To study cardiovascular (CV) risk in urban population of Ukraine. MATERIAL AND METHODS: In a framework of Ukrainian-Russian study conducted in 2009-2013 we registered levels of 20 factors of CV risk in a sample of population of Dnepropetrovsk (n = 1000, 468 men, 532 women, age 30-69 years) and assessed prevalence of very high risk using all variants of the SCORE scale. RESULTS: Factors of CV risk could be distributed into 3 groups according to their prevalence in adult population. Group 1--present in approximately 70% of a population sample: abdominal obesity (criteria of European Society of Cardiology [ESC]), hypercholesterolemia, elevation of low density lipoprotein cholesterol. Group 2--present in about 40% of population sample: abdominal obesity (ATP 3 criteria), arterial hypertension, insulin resistance assessed by HOMA index. Group 3--present in ≤ 30% of population sample: hypertriglyceridemia, abnormal glucose tolerance, smoking, lowering of high density lipoprotein cholesterol, hyperuricemia, and diabetes. CONCLUSION: Analysis of prevalence of risk factors and calculation of CV risk in accordance with ESC recommendations (2012) with the use of all three variants of SCORE allowed to estimate dimension of a cohort with high risk of fatal CV complications as 30% of urban population of Ukraine. This should serve as a basis for further multicenter studies and long-term preventive programs.

Comparative analysis of electrophysiologic effect of metoprolol and disopyramide, acting alone or in combination in patients with supraventricular tachycardia and Wolff-Parkinson-White syndrome.

In the aim of determining an electrophysiologic effect of disopyramide and metoprolol at alone therapy and in combination in patients with supraventricular tachycardia on the background of Wolff-Parkinson-White syndrome 23 persons were examined. All patients were subjected to an intracardiac electrophysiological testing; in its process metoprolol in the dosage of 0.2 mg/kg of body weight, disopyramide in the dosage of 2 mg/kg per body weight both separately and in combination were controlled. It was identified that metoprolol and disopyramide are an effective antiarrhythmic preparates applied for arresting and prevention of reciprocating orthodromic tachycardias in patients with Wolff-Parkinson-White syndrome.

[The amino acid composition of the antigenic structures of the human heart conduction system]. / Aminokislotnyi sostav antigennykh struktur provodiashchei sistemy serdtsa cheloveka.

Amino acid composition of proteins from antigen preparations of the human heart conduction system has been studied. Differences in amino acid composition and relative affinity of the structure of two groups were found: between the sinus and atrioventricular nodes, the His bundle and contractile myocardium.

[The use of obzidan and metoprolol in patients with supraventricular systolic tachyarrhythmias]. / Primenenie obzidana i metoprolola u bol'nykh s supraventrikuliarnymi takhisistolicheskimi aritmiiami.

Having analyzed the electrophysiological mechanisms and state of humoral regulatory substances in 87 patients with paroxysmal disorders of the cardiac rhythm the authors determined the antiarrhythmic action of two beta-blockaders: obsidan and metoprolol. They found a reduction of the sinus node function under the effect of obsidan and to a lesser degree under the effect of metoprolol. Metoprolol produced a high antiarrhythmic effect, particularly in supraventricular tachycardias with participation of abnormal conduction pathways.