Detalhe da pesquisa
1.
Molecular determinants of protein evolvability.
Trends Biochem Sci
; 48(9): 751-760, 2023 09.
Artigo
Inglês
| MEDLINE | ID: mdl-37330341
2.
Insertions and Deletions (Indels): A Missing Piece of the Protein Engineering Jigsaw.
Biochemistry
; 62(2): 148-157, 2023 01 17.
Artigo
Inglês
| MEDLINE | ID: mdl-35830609
3.
Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset.
Proc Natl Acad Sci U S A
; 115(31): E7293-E7302, 2018 07 31.
Artigo
Inglês
| MEDLINE | ID: mdl-30012610
4.
Pervasive epistasis exposes intramolecular networks in adaptive enzyme evolution.
Nat Commun
; 14(1): 8508, 2023 Dec 21.
Artigo
Inglês
| MEDLINE | ID: mdl-38129396
5.
Epistasis and intramolecular networks in protein evolution.
Curr Opin Struct Biol
; 69: 160-168, 2021 08.
Artigo
Inglês
| MEDLINE | ID: mdl-34077895
6.
A mechanistic view of enzyme evolution.
Protein Sci
; 29(8): 1724-1747, 2020 08.
Artigo
Inglês
| MEDLINE | ID: mdl-32557882
7.
Statistical analysis of mutational epistasis to reveal intramolecular interaction networks in proteins.
Methods Enzymol
; 643: 243-280, 2020.
Artigo
Inglês
| MEDLINE | ID: mdl-32896284
8.
Mechanistic Understanding Enables the Rational Design of Salicylanilide Combination Therapies for Gram-Negative Infections.
mBio
; 11(5)2020 09 15.
Artigo
Inglês
| MEDLINE | ID: mdl-32934086
9.
Cryptic genetic variation shapes the adaptive evolutionary potential of enzymes.
Elife
; 82019 02 05.
Artigo
Inglês
| MEDLINE | ID: mdl-30719972
10.
How mutational epistasis impairs predictability in protein evolution and design.
Protein Sci
; 25(7): 1260-72, 2016 07.
Artigo
Inglês
| MEDLINE | ID: mdl-26757214
11.
Ultrahigh-throughput discovery of promiscuous enzymes by picodroplet functional metagenomics.
Nat Commun
; 6: 10008, 2015 Dec 07.
Artigo
Inglês
| MEDLINE | ID: mdl-26639611