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1.
J Orthop Sci ; 28(5): 1023-1026, 2023 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-36117033

RESUMO

BACKGROUND: Knowledge of the proximal edge of the germinal matrix is essential to avoid injuries in the germinal matrix. The previous index such as terminal tendon insertion is not visible from the body surface. The purpose of this study was to examine the relationship between the proximal edge of the germinal matrix and the body surface indexes by ultrasonographic measurements. METHODS: All participants underwent X-rays of the hand and were grouped based on the presence or absence of osteoarthritis in the distal interphalangeal (DIP) joint. The distance from the proximal edge of the germinal matrix to dorsal distal interphalangeal crease (parameter D1), and to ''DIP joint extension boundary line'' (parameter D2) were measured using ultrasonography. RESULTS: Thirty middle fingers of 24 patients were enrolled; 13 fingers were in control group and 17 fingers were in Heberden's node group. The average of parameter D1 was 6.17 mm (SD 1.12) in the control group (N = 13), and was 7.04 mm (SD 1.31) in Heberden's node group (N = 17) without significant difference. The DIP joint extension boundary line was not visible in 7 fingers with severe DIP joint osteoarthritis. The average of parameter D2 was 0.00 mm (SD 0.00) in the control group (N = 13), and was 0.04 mm (SD 0.13) in Heberden's node group (N = 10). CONCLUSIONS: We suggest that DIP joint extension boundary line and dorsal distal interphalangeal crease are valuable indexes to predict the proximal edge of the germinal matrix from the body surface. Though the DIP joint extension boundary line was not visible in some cases, once it has been sighted, the line shows where the germinal matrix exactly is.


Assuntos
Articulações dos Dedos , Osteoartrite , Humanos , Articulações dos Dedos/diagnóstico por imagem , Osteoartrite/diagnóstico por imagem , Dedos , Mãos , Radiografia
2.
BMC Musculoskelet Disord ; 22(1): 421, 2021 May 06.
Artigo em Inglês | MEDLINE | ID: mdl-33957913

RESUMO

BACKGROUND: Isometric exercises for a flexed finger have been reported to be effective for treating trigger finger as the flexor tendon widens the space under the first annular (A1) pulley towards the palmar destination during the exercise. This study aimed to evaluate the structural changes during the A1 pulley stretch in healthy volunteers and patients with trigger finger using ultrasonography. METHODS: We enrolled 25 male and 14 female patients (39 middle fingers). The thickness of the subcutaneous tissue (parameter a), A1 pulley (parameter b), and the flexor tendon (parameter c) and the distance between the dorsal surface of the flexor tendon and the palmar surface of the metacarpal head (parameter d) were measured using ultrasonography of the metacarpophalangeal joint of the middle finger flexed at 45° at rest (pattern A) and under isometric contraction of the flexor tendon against an extension force of the proximal interphalangeal joint (pattern B). RESULTS: The average differences between patterns A and B in the healthy volunteers were 0.29 mm (parameter a; P = 0.02), 0.017 mm (parameter b; P = 0.63), 0.16 (parameter c; P = 0.26), and 0.41 (parameter d; P = 0.004), and those in patients with trigger finger were 0.22 mm (parameter a; P = 0.23), 0.019 mm (parameter b; P = 0.85), 0.03 mm (parameter c; P = 0.82), and 0.78 mm (parameter d; P < 0.001). The distance between the dorsal side of the A1 pulley and the palmar surface of the metacarpal head was also significantly increased by 0.57 mm (8.2%) in healthy volunteers (P < 0.001) and 0.81 mm (11%) in patients with trigger finger (P < 0.001). CONCLUSIONS: In this study, the space under the A1 pulley was expanded under isometric contraction of the flexor tendon. These findings support the effectiveness of pulley stretch exercises for the trigger finger condition.


Assuntos
Dedo em Gatilho , Feminino , Voluntários Saudáveis , Humanos , Contração Isométrica , Masculino , Tendões/diagnóstico por imagem , Dedo em Gatilho/diagnóstico por imagem , Dedo em Gatilho/cirurgia , Ultrassonografia
3.
J Hand Surg Am ; 46(9): 817.e1-817.e7, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-33726935

RESUMO

PURPOSE: This retrospective study aimed to analyze the initial clinical factors associated with surgical intervention for osteoarthritis of the thumb carpometacarpal (CMC) joint. METHODS: The study included patients who first visited our hand surgery clinic, were given the diagnosis of osteoarthritis of the thumb CMC joint between May 2012 and January 2015, and were observed for more than 3 years. Patients were classified into 2 groups according to whether they had undergone surgery during the follow-up period. The following variables were extracted and included in a bivariate analysis: sex, age, age at onset, disease duration, dominant hand, pain visual analog scale (VAS) scores at rest and during use, night pain, Eaton classification, use of an orthosis, number of injections, tender area, range of motion, grip strength, pinch strength, Kapandji abduction index, palmar abduction distance, grind test results, CMC joint shape on radiographs, dorsal subluxation ratio, volar tilt of the metacarpal, presence or absence of ossicles, and the surgeon who recommended the surgery. Variables with P values less than .05 in the bivariate analysis were included in a logistic regression model. RESULTS: The study included 80 thumbs of 48 patients. Pain scores at rest and during use, and the dorsal subluxation ratio were identified as factors significantly associated with surgical intervention in the bivariate analysis. The subsequent logistic regression analysis including these factors as explanatory variables also identified the VAS score at rest and dorsal subluxation ratio as significantly associated with surgical intervention. CONCLUSIONS: The VAS score at rest and the dorsal subluxation ratio at the first clinical visit were associated with the likelihood of future surgical intervention within 3 years in patients with osteoarthritis of the thumb CMC joint. TYPE OF STUDY/LEVEL OF EVIDENCE: Prognostic IV.


Assuntos
Articulações Carpometacarpais , Osteoartrite , Articulações Carpometacarpais/diagnóstico por imagem , Articulações Carpometacarpais/cirurgia , Humanos , Osteoartrite/diagnóstico por imagem , Osteoartrite/cirurgia , Amplitude de Movimento Articular , Estudos Retrospectivos , Polegar/diagnóstico por imagem , Polegar/cirurgia
4.
J Hand Surg Am ; 45(12): 1182.e1-1182.e5, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-32690339

RESUMO

PURPOSE: Although scapholunate interosseous ligament (SLIL) injury is often associated with distal radius fracture, it is frequently missed in x-rays. The purpose of this study was to develop a diagnostic classification based on ultrasonography for SLIL injury and evaluate its diagnostic accuracy. METHODS: Patients who required surgery for distal radius fracture were included in this study. Ultrasonography and arthroscopy were performed in all patients. The original ultrasonography-based classification of the dorsal part of SLIL was developed as follows: for type A, the SLIL surface was outlined clearly as a continuous flat line; for type B, the SLIL surface was outlined clearly as a continuous bulged line; and for type C, the SLIL surface was not continuous, smooth, or outlined clearly. Arthroscopy was performed at the time of osteosynthesis. We classified its findings according to the arthroscopic classification system of Geissler et al and evaluated interobserver and intraobserver reliabilities for our classification on ultrasonography. We also studied the relationship between the ultrasonographic and arthroscopic classifications. RESULTS: In total, 40 patients were included in this study. Weighted κ values for interobserver and intraobserver reliabilities for our ultrasonographic classification were 0.83 (95% confidence interval, 0.70-0.96) and 0.88 (95% confidence interval, 0.77-0.99), respectively. There were 17 patients with type A, 14 with type B, and 9 with type C on ultrasonography. Ultrasonography had a sensitivity of 64% and specificity of 93% for the assumption that type C on ultrasonography corresponded to Geissler grades 3 and 4 on arthroscopy. No patient with type A on ultrasonography was classified as Geissler grades 3 and 4 on arthroscopy. CONCLUSIONS: We concluded that ultrasonography has a high specificity but low sensitivity for the diagnosis of SLIL injury. TYPE OF STUDY/LEVEL OF EVIDENCE: Diagnostic Ⅱ.


Assuntos
Fraturas do Rádio , Traumatismos do Punho , Artroscopia , Humanos , Ligamentos Articulares/diagnóstico por imagem , Ligamentos Articulares/cirurgia , Fraturas do Rádio/diagnóstico por imagem , Fraturas do Rádio/cirurgia , Articulação do Punho
5.
Cureus ; 16(8): e67384, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-39310561

RESUMO

Purpura fulminans (PF) is a rare and life-threatening syndrome characterized by cutaneous purpura resulting from disseminated intravascular coagulation (DIC) and intravascular thrombosis. PF typically develops as a severe complication of infections and is associated with high mortality rates. Effective treatment involves early recognition, aggressive resuscitation, appropriate antibiotic therapy, and the correction of coagulation abnormalities. Nevertheless, despite effective treatment, patients often ultimately require amputation of the affected limbs. This case report details the rehabilitation process of a patient with PF who underwent quadruple amputation. The patient, a 48-year-old male, underwent quadruple amputation due to PF. After intensive care, he was admitted to a convalescent rehabilitation ward for prosthetic rehabilitation. The rehabilitation process combined physical and occupational therapy to facilitate independent living through the use of upper and lower limb prostheses and assistive devices. The patient presented with ulcerative lesions on the anterior surfaces of both knee joints upon admission. During treatment, he developed osteomyelitis of the right patella, which required intravenous antibiotics and limited rehabilitation to bed-based exercises. Following the administration of intravenous therapy, the prosthetist proceeded with the fabrication of lower limb prostheses. Subsequently, the patient was able to commence standing and gait training, and by the time of discharge, he was able to walk without a cane. Upper limb prostheses enabled independence in activities of daily living (ADLs) such as eating, dressing, and toileting. He was also able to perform cooking-related activities that are part of the instrumental activities of daily living (IADLs). This case highlights the importance and achievable outcomes of rehabilitation for patients with PF who have undergone quadruple amputation. A multidisciplinary approach utilizing both upper and lower limb prostheses, as well as assistive devices, enabled significant functional recovery.

6.
J Hand Surg Am ; 38(12): 2348-52, 2013 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-24144614

RESUMO

PURPOSE: To describe surgical outcomes of a series of patients with bony mallet fingers treated by a modified extension blocking technique with external fixation. METHODS: We developed an external fixator that was attached to the extension block pin. Dorsal rotation of the dorsal fragment during reduction was prevented with 1 or 2 additional pins abutted on the fragment through the fixator. We reviewed 12 consecutive patients with mallet finger fractures who were treated surgically with the external fixator. The mean age of the patients was 33 years (range, 15-60 y). RESULTS: Rotation of the fragment during reduction was well controlled in all patients. All fractures united at an average of 5 weeks after surgery. Average extension lag was 2° and active flexion was 74°. No patient reported pain at a final follow-up of 4 months (range, 3-8 mo). According to the Crawford rating scale, 10 patients were classified as excellent and 2 were good. CONCLUSIONS: Our modification of the extension block method prevented dorsal rotation of the fragment during reduction and resulted in early union. TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic IV.


Assuntos
Pinos Ortopédicos , Fixadores Externos , Traumatismos dos Dedos/cirurgia , Fixação de Fratura/instrumentação , Fraturas Ósseas/cirurgia , Amplitude de Movimento Articular/fisiologia , Adolescente , Adulto , Estudos de Coortes , Feminino , Traumatismos dos Dedos/diagnóstico por imagem , Fixação de Fratura/métodos , Consolidação da Fratura/fisiologia , Fraturas Ósseas/diagnóstico por imagem , Deformidades Adquiridas da Mão/diagnóstico por imagem , Deformidades Adquiridas da Mão/cirurgia , Humanos , Escala de Gravidade do Ferimento , Masculino , Pessoa de Meia-Idade , Radiografia , Recuperação de Função Fisiológica , Estudos Retrospectivos , Medição de Risco , Resultado do Tratamento , Adulto Jovem
7.
J Hand Surg Am ; 38(1): 23-8, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23218555

RESUMO

PURPOSE: Neurovascular injury is a serious complication after surgery for Dupuytren disease. The purpose of this study was to evaluate the relationship between the cord and the neurovascular bundle ultrasonographically. METHODS: We included 22 healthy volunteers and 14 Dupuytren disease patients (25 fingers) in this study. We evaluated the cord and the digital artery with high-resolution ultrasound. We first investigated the effect of the angle of metacarpophalangeal joint on the position of the radial and ulnar digital arteries in volunteers without evidence of Dupuytren disease. We compared 3 parameters of the radial and ulnar digital arteries, including differences in depth, differences in lateral shift, and the shape of the cross-section of the artery, between volunteers and patients with Dupuytren disease. RESULTS: None of these parameters changed with flexion of the metacarpophalangeal joint of 0°, 30°, and 60°. Digital arteries and cords could be identified ultrasonographically in all patients, and we confirmed ultrasonographic findings by operative findings in 13 fingers. We classified the fingers into 3 subgroups based on the ultrasonographic findings: type A (n = 13), in which the cord was above the artery; type B (n = 5), in which the cord was below the artery; and type C (n = 7), in which the cord was located between the radial and ulnar digital arteries. Types A, B, and C corresponded to natatory cord/abductor digiti minimi cord, spiral cord, and central cord, respectively. Comparisons among volunteers and patient subgroups showed that the difference in depth in type B patients was significantly larger than that of the other groups. When we set the cutoff point of the difference in depth to 3 mm, sensitivity and specificity to detect the spiral cord were 80% and 76%, respectively. CONCLUSIONS: The relationship between the neurovascular bundle and the type of Dupuytren disease cord can be evaluated by high-resolution ultrasound. TYPE OF STUDY/LEVEL OF EVIDENCE: Diagnostic III.


Assuntos
Contratura de Dupuytren/diagnóstico por imagem , Dedos/inervação , Artérias , Contratura de Dupuytren/fisiopatologia , Dedos/irrigação sanguínea , Dedos/diagnóstico por imagem , Humanos , Articulação Metacarpofalângica/fisiopatologia , Ultrassonografia Doppler em Cores
8.
Cureus ; 15(6): e41024, 2023 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-37519481

RESUMO

We report two cases of shortening of the bone at the stump after amputation. Case 1 was a 57-year-old male with a traumatic transhumeral amputation. The remaining humerus had shortened by 3.5 cm in eight months. Case 2 was a 27-year-old male with a traumatic transtibial amputation. The remaining tibia had shortened by 1.4 cm in 72 months. These two cases had the same cause of amputation, but the amputation site, age, and time course differed. Few studies have examined the bone length of stumps after amputation. The bone length of stumps is generally assumed to not change after amputation. However, the residual bone at the stump can shorten after amputation.

9.
Mod Rheumatol ; 22(6): 903-6, 2012 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-22350574

RESUMO

A 60-year-old woman with rheumatoid arthritis, who had been treated with infliximab, presented with uncontrollable wrist arthritis. Fungal arthritis caused by Candida parapsilosis was confirmed by examining her aspirated joint fluid. Her infliximab therapy was interrupted, and antifungal therapy with fluconazole was started. After the fungal infection had been ameliorated, surgical debridement and arthrodesis of the wrist joint were conducted, and her symptoms completely resolved. Although fungal arthritis is rare, it should be considered as a differential diagnosis of exacerbated monoarthritis in patients treated with biological agents.


Assuntos
Anticorpos Monoclonais/uso terapêutico , Antirreumáticos/uso terapêutico , Artrite Infecciosa/microbiologia , Artrite Reumatoide/tratamento farmacológico , Candida/isolamento & purificação , Candidíase/tratamento farmacológico , Articulação do Punho/microbiologia , Antifúngicos/uso terapêutico , Artrite Infecciosa/tratamento farmacológico , Artrite Infecciosa/cirurgia , Candidíase/cirurgia , Desbridamento , Feminino , Fluconazol/uso terapêutico , Humanos , Infliximab , Pessoa de Meia-Idade , Articulação do Punho/cirurgia
10.
J Orthop Surg (Hong Kong) ; 30(2): 10225536221103301, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35722961

RESUMO

BACKGROUND: Ligament reconstruction and tendon interposition (LRTI) is currently the most performed procedure for osteoarthritis (OA) of the thumb carpometacarpal (CMC) joint. In general, satisfactory outcomes are expected, although some patients complain of residual pain after LRTI. The objective of this study is to determine the factors associated with residual pain. METHOD: All patients with OA of the thumb CMC joint who underwent LRTI at our hospital between October 2013 and October 2018 and were regularly observed for at least 1 year were included. The following variables were extracted and included in the univariate analysis: sex, age, dominant hand, pain visual analog scale (VAS) score, Eaton classification, grip strength, pulp pinch strength, and metacarpophalangeal joint hyperextension angle were recorded as variables. Mann-Whitney U test or Fisher exact test was used for univariate analysis of the above factors, and then multivariate logistic regression analysis was performed to find out the factors associated with residual pain. RESULTS: The study included 60 thumbs of 53 patients. Eleven thumbs had postoperative residual pain. The surgery on the dominant hand was significantly associated with the presence of postoperative residual pain, especially in males. CONCLUSIONS: Dominant hand was associated with residual pain after LRTI for OA of the thumb CMC joint, although residual pain was minimal. Our findings will help in preoperative and postoperative counseling of patients. In the future, our results may also help select surgical procedures according to the patient's characteristics.


Assuntos
Articulações Carpometacarpais , Osteoartrite , Artroplastia/métodos , Articulações Carpometacarpais/cirurgia , Humanos , Ligamentos/cirurgia , Masculino , Osteoartrite/cirurgia , Dor/cirurgia , Fatores de Risco , Tendões/cirurgia
11.
Knee Surg Sports Traumatol Arthrosc ; 19(3): 424-31, 2011 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-20814663

RESUMO

PURPOSE: The purpose of this study was to know which tunnel--the anteromedial (AM) bundle or the posterolateral (PL) bundle--should be prepared first to create the 2 femoral tunnels accurately in anatomic double-bundle (DB) anterior cruciate ligament (ACL) reconstruction. METHODS: Thirty-four patients were divided into 2 groups of 17 depending on the sequence of preparation of the 2 femoral tunnels. In group A, the AM tunnel was prepared first, whereas the PL tunnel was prepared first in group P. ACL reconstruction was performed using a three-dimensional (3-D) fluoroscopy-based navigation system to place the double femoral tunnels through an accessory medial portal. The double femoral socket positioning was evaluated by 3-D computed tomography (CT) scan image. RESULTS: The non-anatomical placement of the femoral sockets occurred in 5 patients (29%) in group A, whereas the 2 sockets were placed anatomically in all patients in group P (P < 0.05). Evaluation of the AM and the PL socket location on the 3-D CT images using the quadrant method showed more similar values to the laboratory data in a literature in group P than in group A. No complication occurred in group A, whereas complications such as socket communications or back wall blowout occurred in 5 patients (29%) in group P (P < 0.05). CONCLUSION: The sequence of creating 2 femoral tunnels through accessory medial portal affected the resultant location of the sockets and the rate of the complications. When femoral tunnels are prepared with a transportal technique, PL tunnel first technique seems to be superior to AM first technique regarding anatomic placement. However, PL tunnel first technique accompanies the risk of socket communication.


Assuntos
Ligamento Cruzado Anterior/cirurgia , Artroscopia/métodos , Imageamento Tridimensional , Articulação do Joelho/anatomia & histologia , Procedimentos de Cirurgia Plástica/métodos , Adolescente , Adulto , Ligamento Cruzado Anterior/anatomia & histologia , Ligamento Cruzado Anterior/diagnóstico por imagem , Artroscópios , Estudos de Coortes , Feminino , Fêmur/anatomia & histologia , Fêmur/diagnóstico por imagem , Fêmur/cirurgia , Fluoroscopia , Humanos , Processamento de Imagem Assistida por Computador , Articulação do Joelho/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Monitorização Intraoperatória/métodos , Tomografia Computadorizada por Raios X/métodos , Resultado do Tratamento , Adulto Jovem
12.
J Hand Surg Am ; 36(9): 1486-91, 2011 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-21802865

RESUMO

PURPOSE: The cause of snapping in trigger finger is not clearly understood. The purpose of this study was to investigate the influence of stiffness of the first annular pulley on snapping in trigger finger patients with sonoelastography, a new technique for quantitative assessment of the stiffness of soft tissues. METHODS: We first studied 20 healthy volunteers (all women, aged 24-78 y) to define the change of stiffness with aging and with specific fingers. We then studied 10 digits of 9 patients (all women, aged 60-78 y) with trigger finger that involved middle or ring fingers. Thickness and stiffness were evaluated by sonoelastography. Stiffness was estimated by strain ratio of subcutaneous fat to the pulley (F/P strain ratio). The patients were treated with corticosteroid injection, and the measurement was repeated 3 weeks later. RESULTS: In the healthy volunteers, both thickness and F/P strain ratio showed a positive correlation with age. There was no difference between the middle and ring fingers. In trigger finger patients, the pulley thicknesses of the affected finger and the adjacent normal finger before corticosteroid injection were 0.99 ± 0.19 mm and 0.60 ± 0.14 mm (mean ± SD), respectively. The F/P strain ratios of the affected finger and the adjacent normal finger before the injection were 4.2 ± 1.3 and 2.4 ± 0.63, respectively. Three weeks after the injection, snapping disappeared in all patients, the pulley thickness decreased to 0.61 ± 0.15 mm, and the F/P strain ratio decreased to 2.5 ± 0.68. The cross-sectional area for flexor tendons within the pulley did not change after the injection. CONCLUSIONS: Increased stiffness and thickening of the A1 pulley are considered to be causes for snapping in trigger finger, and corticosteroid injection can alleviate snapping by changing these 2 features.


Assuntos
Tendões/diagnóstico por imagem , Tendões/fisiopatologia , Dedo em Gatilho/fisiopatologia , Adulto , Fatores Etários , Idoso , Estudos de Casos e Controles , Técnicas de Imagem por Elasticidade , Feminino , Glucocorticoides/uso terapêutico , Humanos , Injeções , Pessoa de Meia-Idade , Gordura Subcutânea/patologia , Triancinolona Acetonida/uso terapêutico , Dedo em Gatilho/tratamento farmacológico
13.
JAMA Netw Open ; 4(11): e2133604, 2021 11 01.
Artigo em Inglês | MEDLINE | ID: mdl-34751757

RESUMO

Importance: The optimal management for acute traumatic cervical spinal cord injury (SCI) is unknown. Objective: To determine whether early surgical decompression results in better motor recovery than delayed surgical treatment in patients with acute traumatic incomplete cervical SCI associated with preexisting canal stenosis but without bone injury. Design, Setting, and Participants: This multicenter randomized clinical trial was conducted in 43 tertiary referral centers in Japan from December 2011 through November 2019. Patients aged 20 to 79 years with motor-incomplete cervical SCI with preexisting canal stenosis (American Spinal Injury Association [ASIA] Impairment Scale C; without fracture or dislocation) were included. Data were analyzed from September to November 2020. Interventions: Patients were randomized to undergo surgical treatment within 24 hours after admission or delayed surgical treatment after at least 2 weeks of conservative treatment. Main Outcomes and Measures: The primary end points were improvement in the mean ASIA motor score, total score of the spinal cord independence measure, and the proportion of patients able to walk independently at 1 year after injury. Results: Among 72 randomized patients, 70 patients (mean [SD] age, 65.1 [9.4] years; age range, 41-79 years; 5 [7%] women and 65 [93%] men) were included in the full analysis population (37 patients assigned to early surgical treatment and 33 patients assigned to delayed surgical treatment). Of these, 56 patients (80%) had data available for at least 1 primary outcome at 1 year. There was no significant difference among primary end points for the early surgical treatment group compared with the delayed surgical treatment group (mean [SD] change in ASIA motor score, 53.7 [14.7] vs 48.5 [19.1]; difference, 5.2; 95% CI, -4.2 to 14.5; P = .27; mean [SD] SCIM total score, 77.9 [22.7] vs 71.3 [27.3]; P = .34; able to walk independently, 21 of 30 patients [70.0%] vs 16 of 26 patients [61.5%]; P = .51). A mixed-design analysis of variance revealed a significant difference in the mean change in ASIA motor scores between the groups (F1,49 = 4.80; P = .03). The early surgical treatment group, compared with the delayed surgical treatment group, had greater motor scores than the delayed surgical treatment group at 2 weeks (mean [SD] score, 34.2 [18.8] vs 18.9 [20.9]), 3 months (mean [SD] score, 49.1 [15.1] vs 37.2 [20.9]), and 6 months (mean [SD] score, 51.5 [13.9] vs 41.3 [23.4]) after injury. Adverse events were common in both groups (eg, worsening of paralysis, 6 patients vs 6 patients; death, 3 patients vs 3 patients). Conclusions and Relevance: These findings suggest that among patients with cervical SCI, early surgical treatment produced similar motor regain at 1 year after injury as delayed surgical treatment but showed accelerated recovery within the first 6 months. These exploratory results suggest that early surgical treatment leads to faster neurological recovery, which requires further validation. Trial Registration: ClinicalTrials.gov Identifier: NCT01485458; umin.ac.jp/ctr Identifier: UMIN000006780.


Assuntos
Medula Cervical/lesões , Vértebras Cervicais/lesões , Descompressão Cirúrgica/estatística & dados numéricos , Traumatismos da Medula Espinal/cirurgia , Tempo para o Tratamento/estatística & dados numéricos , Adulto , Idoso , Medula Cervical/cirurgia , Vértebras Cervicais/cirurgia , Tratamento Conservador/estatística & dados numéricos , Descompressão Cirúrgica/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Período Pós-Operatório , Desempenho Psicomotor , Recuperação de Função Fisiológica , Traumatismos da Medula Espinal/fisiopatologia , Fatores de Tempo , Resultado do Tratamento , Adulto Jovem
14.
J Cell Biochem ; 109(4): 755-63, 2010 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-20058231

RESUMO

Since bone resorption and formation by continuous and intermittent parathyroid hormone (PTH) treatments involve various types of cells in bone, this study examined the underlying mechanism by combining culture systems using mouse primary calvarial osteoblasts and bone marrow cells. The PTH/PTHrP receptor (PTH1R) expression and the cAMP accumulation in response to PTH were increased in accordance with the differentiation of osteoblasts. Osteoclast formation was strongly induced by continuous PTH treatment in the monolayer co-culture of osteoblasts and bone marrow cells, which was associated with RANKL expression in differentiated osteoblasts. Bone formation determined by ALP activity and the type I collagen mRNA expression was stimulated by intermittent PTH treatment in the monolayer co-culture and in the bone marrow cell layer of the separated co-culture in a double chamber dish, but not in the culture of bone marrow cells alone. The stimulation in the separated co-culture, accompanied by IGF-I production by osteoblasts, was abolished when bone marrow cells were derived from knockout mice of insulin-receptor substrate-1 (IRS-1-/-) or when osteoblasts were from PTH1R-/- mice. We conclude that differentiated osteoblasts are most likely the direct target of both continuous and intermittent PTH, while bone marrow cells are likely the effector cells. The osteoblasts stimulated by continuous PTH express RANKL which causes osteoclastogenesis from the precursors in bone marrow via cell-to-cell contact, leading to bone resorption; while the osteoblasts stimulated by intermittent PTH secrete IGF-I which activates IRS-1 in osteoblast precursors in bone marrow via a paracrine mechanism, leading to bone formation.


Assuntos
Osso e Ossos/metabolismo , Hormônio Paratireóideo/fisiologia , Animais , Células da Medula Óssea/citologia , Comunicação Celular , Técnicas de Cocultura , Proteínas Substratos do Receptor de Insulina , Fator de Crescimento Insulin-Like I , Camundongos , Osteoblastos/citologia , Osteogênese , Ligante RANK/biossíntese
15.
J Orthop Surg (Hong Kong) ; 28(3): 2309499020959151, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32996436

RESUMO

PURPOSE: The Disabilities of the Arm, Shoulder, and Hand (DASH) is the most widely used patient-oriented outcome measure for the upper extremities in the world, and high reliability and validity of it has already been confirmed. However, there are several problems with using the DASH, some of which are culturally related. We aimed to (1) develop a patient-oriented disease-specific outcome measure for patients with disorders of the hand and elbow, which we call the HandQ and (2) examine the practical applicability, reliability, and validity of the HandQ for any patient with disorders of the hand and elbow. METHODS: A total of 216 patients were surveyed with the HandQ, as well as the Hand20 and the DASH to assess psychometric characteristics. RESULTS: There were no considerable floor and ceiling effects regarding the total HandQ score. Test-retest reliability and internal consistency determined using the intraclass correlation coefficient (0.942) and Cronbach's α test (0.961) were excellent. The HandQ was well correlated with the Hand20 and the DASH scores. Scree plot showed unidimensionality of the HandQ, and the graphical model showed the questionnaire items of the HandQ had reasonable correlation among each item. CONCLUSIONS: The HandQ has a sufficient reliability and internal consistency, and an excellent validity, and was shown to be able to be practically applicable in all patients with hand and elbow disorders.


Assuntos
Avaliação da Deficiência , Artropatias/reabilitação , Medidas de Resultados Relatados pelo Paciente , Psicometria/métodos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Articulação do Cotovelo , Feminino , Articulação da Mão , Humanos , Masculino , Pessoa de Meia-Idade , Reprodutibilidade dos Testes , Inquéritos e Questionários , Adulto Jovem
17.
Biochem Biophys Res Commun ; 365(2): 252-7, 2008 Jan 11.
Artigo em Inglês | MEDLINE | ID: mdl-17983595

RESUMO

Phosphorylated p38 mitogen-activating kinase (MAPK) is observed in osteoclasts under in vivo inflammatory situations. However, the role of p38 MAPK in osteoclast function has not been elucidated, because all external stimuli tested hitherto failed to induce the phosphorylation of p38 MAPK in osteoclasts in culture. In this study, a constitutively active form of MKK6 (MKK6CA) was expressed in osteoclasts using adenoviral gene transfer in vitro. MKK6CA expressed in osteoclasts phosphorylated p38 MAPK and enhanced the survival of osteoclasts. Dentine-resorbing activity of osteoclasts was not enhanced by the MKK6CA expression. These results suggest that p38 MAPK signaling plays a critical role in the survival of osteoclasts in inflammatory diseases.


Assuntos
Reabsorção Óssea/metabolismo , MAP Quinase Quinase 6/metabolismo , Sistema de Sinalização das MAP Quinases , Osteoclastos/metabolismo , Osteoclastos/patologia , Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo , Animais , Animais Recém-Nascidos , Sobrevivência Celular , Células Cultivadas , Camundongos
18.
Arthroscopy ; 24(10): 1161-7, 2008 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-19028169

RESUMO

In anatomic double-bundle anterior cruciate ligament (ACL) reconstruction, it is more technically demanding, even for experienced surgeons, to place 2 femoral tunnels within the ACL attachment than to place 2 tibial tunnels. We describe a technique using a three-dimensional (3-D) fluoroscopy-based navigation system to place 2 femoral tunnels accurately. After a reference frame is rigidly attached to the femur, an intraoperative image of the distal femur is obtained. The image is transferred to a navigation system and reconstructed into a 3-D image. During the placement of guidewires for the femoral tunnels through an accessory medial portal, a femoral guide with a tracker feeds back to the surgeons the direction of the guidewire on the 3-D femur bone surface image in real-time. The femoral guide is placed at the center of the footprint with the aid of visual guidance of the navigation and an arthroscopic view. The flexion angle of the knee is then adjusted to prevent posterior blowout on the computer screen during insertion of the guidewire. The length of the femoral tunnel can also be estimated before overdrilling the guidewire. This technology allows surgeons to place 2 femoral tunnels precisely without any complication during anatomic double-bundle ACL reconstruction.


Assuntos
Ligamento Cruzado Anterior/anatomia & histologia , Ligamento Cruzado Anterior/cirurgia , Artroscopia/métodos , Ligamento Cruzado Anterior/diagnóstico por imagem , Fêmur/anatomia & histologia , Fêmur/diagnóstico por imagem , Fêmur/cirurgia , Fluoroscopia/métodos , Humanos , Processamento de Imagem Assistida por Computador/métodos , Imageamento Tridimensional/métodos , Monitorização Intraoperatória , Procedimentos de Cirurgia Plástica/métodos , Tomografia Computadorizada por Raios X , Interface Usuário-Computador
19.
Hand Surg ; 13(3): 153-8, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-19378359

RESUMO

Many modifications to trapeziectomy have been proposed for the treatment of thumb basal joint arthritis. Their final outcomes have been discussed intensively, whereas functional changes in the early post-operative period have not been fully documented. The purpose of the present study is to evaluate an early functional change following our modified ligament reconstruction with tendon interposition (LRTI) arthroplasty. Nine patients (ten thumbs) were included in this study. Pain levels, strength, and mobility were assessed before and after surgery at intervals of two months. Pain level significantly improved at two months after surgery. Grip and pinch strengths had increased gradually after a temporal decrease at two-month follow-up, and were significantly stronger at six months after surgery. Palmar abduction improved significantly at six months after surgery, whereas opposition did not change significantly. A modified LRTI is an effective procedure in terms of early functional improvement of pain, strength, and mobility.


Assuntos
Artroplastia/métodos , Articulações Carpometacarpais/cirurgia , Ligamentos Articulares/cirurgia , Osteoartrite/cirurgia , Tendões/transplante , Idoso , Feminino , Força da Mão , Humanos , Pessoa de Meia-Idade , Movimento , Medição da Dor , Polegar/cirurgia , Trapézio/cirurgia
20.
J Hand Microsurg ; 10(3): 125-129, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30483017

RESUMO

Background Although dorsal subluxation is a typical finding for osteoarthritis of the thumb carpometacarpal (CMC) joint, it is difficult to evaluate the subluxation after trapeziectomy and the significance of its surgical correction combined with trapeziectomy is still controversial. The purpose of this study was to develop a method to evaluate dorsal subluxation without using landmarks on the trapezium. Methods Thirty patients with thumb CMC arthritis and 13 normal patients were included in this study. Dorsal subluxation of the CMC joint was evaluated by measuring the distance between the volar tip of the thumb metacarpal base and dorsoradial border of the index metacarpal base (M1M2 overlap) on the X-ray true lateral view of the thumb as well as previously reported methods. Intraclass correlation coefficient (ICC) was used to assess inter- and intraobserver reliability for the measurement of M1M2 overlap by six examiners of different level of expertise. Dorsal subluxation was also evaluated after trapeziectomy with ligament reconstruction. Results There were almost perfect interobserver (ICC = 0.94) and intraobserver (ICC = 0.95 for an expert and 0.97 for a novice) reliabilities for the measurement of M1M2 overlap. There was a weak correlation between our method and previously reported methods. M1M2 overlap of the normal patients and the patients were 4.6 ± 1.2 mm and 2.3 ± 2.3 mm (mean ± SD), respectively. M1M2 overlap was corrected significantly after trapeziectomy with ligament reconstruction. Conclusion Dorsal subluxation of the thumb CMC joint could be evaluated by M1M2 overlap before and after trapeziectomy.

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