1.
Org Biomol Chem
; 7(4): 777-84, 2009 Feb 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19194593
RESUMO
Key relationships between the intramolecular H-bond-derived backbone conformation and the bioactivity of the novel fat-accumulation inhibitor (-)-ternatin are examined by analyses of the NMR spectroscopic data and CD spectra of designed analogues. The results reveal that the beta-turn structure of (-)-ternatin is responsible for its potent fat-accumulation inhibitory effect against 3T3-L1 murine adipocytes.
Assuntos
Adipócitos/citologia , Gorduras na Dieta/antagonistas & inibidores , Flavonoides/química , Obesidade/prevenção & controle , Células 3T3-L1 , Adipócitos/metabolismo , Animais , Flavonoides/farmacologia , Metabolismo dos Lipídeos/efeitos dos fármacos , Espectroscopia de Ressonância Magnética , Camundongos , Relação Estrutura-Atividade
2.
J Med Chem
; 51(19): 5912-4, 2008 Oct 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18798610
RESUMO
A series of Ala and Aoc analogues of (-)-ternatin were prepared, and their bioactivities were assessed by a fat-accumulation inhibition assay using 3T3-L1 adipocytes, which led to the discovery of key structure-activity relationships (SAR).