Detalhe da pesquisa
1.
Proarrhythmia risk prediction using human induced pluripotent stem cell-derived cardiomyocytes.
J Pharmacol Sci
; 136(4): 249-256, 2018 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-29555184
2.
Hsp90 inhibitor geldanamycin attenuates the cytotoxicity of sunitinib in cardiomyocytes via inhibition of the autophagy pathway.
Toxicol Appl Pharmacol
; 329: 282-292, 2017 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28624441
3.
Assessment of testing methods for drug-induced repolarization delay and arrhythmias in an iPS cell-derived cardiomyocyte sheet: multi-site validation study.
J Pharmacol Sci
; 124(4): 494-501, 2014.
Artigo
Inglês
| MEDLINE | ID: mdl-24694996
4.
Prediction of relaxin-3-induced downstream pathway resulting in anxiolytic-like behaviors in rats based on a microarray and peptidome analysis.
J Recept Signal Transduct Res
; 33(4): 224-33, 2013 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-23697547
5.
Chronic probucol treatment decreases the slow component of the delayed-rectifier potassium current in CHO cells transfected with KCNQ1 and KCNE1: a novel mechanism of QT prolongation.
J Cardiovasc Pharmacol
; 59(4): 377-86, 2012 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-22189896
6.
N-type calcium channel in the pathogenesis of experimental autoimmune encephalomyelitis.
J Biol Chem
; 285(43): 33294-33306, 2010 Oct 22.
Artigo
Inglês
| MEDLINE | ID: mdl-20720005
7.
Molecular Profiling of Human Induced Pluripotent Stem Cell-Derived Cells and their Application for Drug Safety Study.
Curr Pharm Biotechnol
; 21(9): 807-828, 2020.
Artigo
Inglês
| MEDLINE | ID: mdl-32321398
8.
Quantitative mouse brain proteomics using culture-derived isotope tags as internal standards.
Nat Biotechnol
; 23(5): 617-21, 2005 May.
Artigo
Inglês
| MEDLINE | ID: mdl-15834404
9.
[Method for MEA Data Analysis of Drug-treated Rat Primary Neurons and Human iPSC-derived Neurons to Evaluate the Risk of Drug-induced Seizures].
Yakugaku Zasshi
; 138(6): 823-828, 2018.
Artigo
Japonês
| MEDLINE | ID: mdl-29863054
10.
Comprehensive in vitro cardiac safety assessment using human stem cell technology: Overview of CSAHi HEART initiative.
J Pharmacol Toxicol Methods
; 83: 42-54, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-27646297
11.
CSAHi study: Detection of drug-induced ion channel/receptor responses, QT prolongation, and arrhythmia using multi-electrode arrays in combination with human induced pluripotent stem cell-derived cardiomyocytes.
J Pharmacol Toxicol Methods
; 85: 73-81, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-28163191
12.
A new paradigm for drug-induced torsadogenic risk assessment using human iPS cell-derived cardiomyocytes.
J Pharmacol Toxicol Methods
; 84: 111-127, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-27956204
13.
Functional Characterization of Acetylcholine Receptors Expressed in Human Neurons Differentiated from Hippocampal Neural Stem/Progenitor Cells.
J Biomol Screen
; 21(10): 1065-1074, 2016 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-27572608
14.
Electrophysiological Characteristics of Human iPSC-Derived Cardiomyocytes for the Assessment of Drug-Induced Proarrhythmic Potential.
PLoS One
; 11(12): e0167348, 2016.
Artigo
Inglês
| MEDLINE | ID: mdl-27923051
15.
CSAHi study: Evaluation of multi-electrode array in combination with human iPS cell-derived cardiomyocytes to predict drug-induced QT prolongation and arrhythmia--effects of 7 reference compounds at 10 facilities.
J Pharmacol Toxicol Methods
; 78: 93-102, 2016.
Artigo
Inglês
| MEDLINE | ID: mdl-26657830
16.
N-type calcium channel alpha1B subunit (Cav2.2) knock-out mice display hyperactivity and vigilance state differences.
J Neurosci
; 23(17): 6793-7, 2003 Jul 30.
Artigo
Inglês
| MEDLINE | ID: mdl-12890773
17.
Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice.
BMC Neurosci
; 6: 33, 2005 May 06.
Artigo
Inglês
| MEDLINE | ID: mdl-15876356
18.
Increased glucose tolerance in N-type Ca2+ channel alpha(1B)-subunit gene-deficient mice.
Int J Mol Med
; 15(6): 937-44, 2005 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-15870896
19.
Utilization of iPSC Technologies for Drug-Induced Risk and Drug Efficacy Evaluation During Drug Development.
Curr Pharm Biotechnol
; 21(9): 750-751, 2020.
Artigo
Inglês
| MEDLINE | ID: mdl-32830622
20.
Improvement of acquisition and analysis methods in multi-electrode array experiments with iPS cell-derived cardiomyocytes.
J Pharmacol Toxicol Methods
; 75: 17-26, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-25910965