Detalhe da pesquisa
1.
Mutated Toll-like receptor 9 increases Alzheimer's disease risk by compromising innate immunity protection.
Mol Psychiatry
; 2023 Jul 11.
Artigo
Inglês
| MEDLINE | ID: mdl-37433968
2.
Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays.
J Biol Chem
; 295(12): 4001-4013, 2020 03 20.
Artigo
Inglês
| MEDLINE | ID: mdl-32034092
3.
Clinical evaluation of [18F] JNJ-64326067, a novel candidate PET tracer for the detection of tau pathology in Alzheimer's disease.
Eur J Nucl Med Mol Imaging
; 47(13): 3176-3185, 2020 12.
Artigo
Inglês
| MEDLINE | ID: mdl-32535652
4.
The Dynamics and Turnover of Tau Aggregates in Cultured Cells: INSIGHTS INTO THERAPIES FOR TAUOPATHIES.
J Biol Chem
; 291(25): 13175-93, 2016 Jun 17.
Artigo
Inglês
| MEDLINE | ID: mdl-27129267
5.
LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism.
J Cell Sci
; 128(3): 54152, 2015 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25501810
6.
Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo.
Acta Neuropathol
; 133(5): 731-749, 2017 05.
Artigo
Inglês
| MEDLINE | ID: mdl-28083634
7.
Comparison of New Tau PET-Tracer Candidates With [18F]T808 and [18F]T807.
Mol Imaging
; 152016.
Artigo
Inglês
| MEDLINE | ID: mdl-27030397
8.
Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo.
Acta Neuropathol
; 131(4): 549-69, 2016 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-26739002
9.
Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice.
Neurobiol Dis
; 73: 83-95, 2015 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-25220759
10.
Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice.
Acta Neuropathol
; 129(6): 875-94, 2015 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-25862635
11.
The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo.
J Biol Chem
; 287(31): 25927-40, 2012 Jul 27.
Artigo
Inglês
| MEDLINE | ID: mdl-22692213
12.
microRNA-132 regulates gene expression programs involved in microglial homeostasis.
iScience
; 26(6): 106829, 2023 Jun 16.
Artigo
Inglês
| MEDLINE | ID: mdl-37250784
13.
Time course of tinnitus development following noise exposure in mice.
J Neurosci Res
; 90(7): 1480-8, 2012 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-22434653
14.
Requirement of central ghrelin signaling for alcohol reward.
Proc Natl Acad Sci U S A
; 106(27): 11318-23, 2009 Jul 07.
Artigo
Inglês
| MEDLINE | ID: mdl-19564604
15.
The 3-O sulfation of heparan sulfate proteoglycans contributes to the cellular internalization of tau aggregates.
BMC Mol Cell Biol
; 23(1): 61, 2022 Dec 24.
Artigo
Inglês
| MEDLINE | ID: mdl-36564747
16.
A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid ß In Vivo.
ACS Med Chem Lett
; 13(1): 76-83, 2022 Jan 13.
Artigo
Inglês
| MEDLINE | ID: mdl-35059126
17.
Vesicular glutamate transporter VGLUT1 has a role in hippocampal long-term potentiation and spatial reversal learning.
Cereb Cortex
; 20(3): 684-93, 2010 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-19574394
18.
Discovery of Extremely Selective Fused Pyridine-Derived ß-Site Amyloid Precursor Protein-Cleaving Enzyme (BACE1) Inhibitors with High In Vivo Efficacy through 10s Loop Interactions.
J Med Chem
; 64(19): 14165-14174, 2021 10 14.
Artigo
Inglês
| MEDLINE | ID: mdl-34553947
19.
Structure-Based Approaches to Improving Selectivity through Utilizing Explicit Water Molecules: Discovery of Selective ß-Secretase (BACE1) Inhibitors over BACE2.
J Med Chem
; 64(6): 3075-3085, 2021 03 25.
Artigo
Inglês
| MEDLINE | ID: mdl-33719429
20.
JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate.
J Med Chem
; 64(19): 14175-14191, 2021 10 14.
Artigo
Inglês
| MEDLINE | ID: mdl-34553934