Detalhe da pesquisa
1.
Development of a Selective and High Affinity Radioligand, [3H]VU6013720, for the M4 Muscarinic Receptor.
Mol Pharmacol
; 104(5): 195-202, 2023 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-37595966
2.
The muscarinic M4 acetylcholine receptor exacerbates symptoms of movement disorders.
Biochem Soc Trans
; 51(2): 691-702, 2023 04 26.
Artigo
Inglês
| MEDLINE | ID: mdl-37013974
3.
Activation of the mGlu1 metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M4 muscarinic receptor allosteric modulators.
Mol Psychiatry
; 25(11): 2786-2799, 2020 11.
Artigo
Inglês
| MEDLINE | ID: mdl-30116027
4.
Roles of the M4 acetylcholine receptor in the basal ganglia and the treatment of movement disorders.
Mov Disord
; 34(8): 1089-1099, 2019 08.
Artigo
Inglês
| MEDLINE | ID: mdl-31211471
5.
Allosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice.
Proc Natl Acad Sci U S A
; 112(45): 14078-83, 2015 Nov 10.
Artigo
Inglês
| MEDLINE | ID: mdl-26508634
6.
α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration.
Neurobiol Dis
; 105: 84-98, 2017 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-28576704
7.
The G2019S LRRK2 mutation increases myeloid cell chemotactic responses and enhances LRRK2 binding to actin-regulatory proteins.
Hum Mol Genet
; 24(15): 4250-67, 2015 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25926623
8.
Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury.
Hum Mol Genet
; 24(14): 4078-93, 2015 Jul 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25904107
9.
Abrogation of α-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats.
Proc Natl Acad Sci U S A
; 111(25): 9289-94, 2014 Jun 24.
Artigo
Inglês
| MEDLINE | ID: mdl-24927544
10.
Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration.
J Biol Chem
; 290(32): 19433-44, 2015 Aug 07.
Artigo
Inglês
| MEDLINE | ID: mdl-26078453
11.
Corrigendum to "α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration" [Neurobiol. Dis., Volume 105 (2017) Article 84, 98].
Neurobiol Dis
; 159: 105506, 2021 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-34565675
12.
Unique functional and structural properties of the LRRK2 protein ATP-binding pocket.
J Biol Chem
; 289(47): 32937-51, 2014 Nov 21.
Artigo
Inglês
| MEDLINE | ID: mdl-25228699
13.
LRRK2 secretion in exosomes is regulated by 14-3-3.
Hum Mol Genet
; 22(24): 4988-5000, 2013 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-23886663
14.
G α olf Regulates Biochemical Signaling in Neurons Associated with Movement Control and Initiation.
bioRxiv
; 2024 Apr 05.
Artigo
Inglês
| MEDLINE | ID: mdl-38617339
15.
LRRK2 inhibition attenuates microglial inflammatory responses.
J Neurosci
; 32(5): 1602-11, 2012 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22302802
16.
Inhibition of LRRK2 kinase activity rescues deficits in striatal dopamine physiology in VPS35 p.D620N knock-in mice.
NPJ Parkinsons Dis
; 9(1): 167, 2023 Dec 18.
Artigo
Inglês
| MEDLINE | ID: mdl-38110354
17.
Cholinergic system changes in Parkinson's disease: emerging therapeutic approaches.
Lancet Neurol
; 21(4): 381-392, 2022 04.
Artigo
Inglês
| MEDLINE | ID: mdl-35131038
18.
Discovery of the First Selective M4 Muscarinic Acetylcholine Receptor Antagonists with in Vivo Antiparkinsonian and Antidystonic Efficacy.
ACS Pharmacol Transl Sci
; 4(4): 1306-1321, 2021 Aug 13.
Artigo
Inglês
| MEDLINE | ID: mdl-34423268
19.
Co-Activation of Metabotropic Glutamate Receptor 3 and Beta-Adrenergic Receptors Modulates Cyclic-AMP and Long-Term Potentiation, and Disrupts Memory Reconsolidation.
Neuropsychopharmacology
; 42(13): 2553-2566, 2017 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-28664928
20.
Cholinergic Projections to the Substantia Nigra Pars Reticulata Inhibit Dopamine Modulation of Basal Ganglia through the M4 Muscarinic Receptor.
Neuron
; 96(6): 1358-1372.e4, 2017 12 20.
Artigo
Inglês
| MEDLINE | ID: mdl-29268098