Correlation between three assessment pain tools in subacromial pain syndrome.

OBJECTIVE: To compare the correlation of Visual Analog Scale with pain subsections of Shoulder Pain and Disability Index and Constant-Murley Score in subacromial pain syndrome patients. DESIGN: Single cross-sectional analysis. SETTING: Hospital Rehabilitation Department. METHODS: The assessment tools were applied at baseline. Correlations between Visual Analog Scale, Shoulder Pain and Disability Index and Constant-Murley Score pain subsections were assessed by Pearson correlation coefficient. Linear regression models were calculated between scales. Statistical significance was set at two-sided p < 0.05. RESULTS: Forty-three patients were included. Pearson's correlation between assessments was for Visual Analog Scale-Shoulder Pain Disability Index-pain (r = 0.61, p < 0.001) and for Visual Analog Scale-Constant Murley Score-pain were (r = -0.74, p < 0.001). Visual Analog Scale-Shoulder Pain and Disability Index-pain determination coefficient was r2 = 0.37 and r2 = 0.54 for Visual Analog Scale-Constant-Murley Score-pain. CONCLUSIONS: Visual Analog Scale showed better correlation with Constant Murley Score-pain than with Shoulder Pain and Disability Index-pain in subacromial pain syndrome patients.

[Health-related quality of life in patients diagnosed with subacromial syndrome in the Talavera Integrated Area]. / Calidad de vida relacionada con la salud en los pacientes diagnosticados de síndrome subacromial en el Área Integrada de Talavera.

OBJECTIVE: There is a high prevalence of subacromial syndrome among patients with shoulder pathology, where the pain and tendency to chronification are some of its most important characteristics. This is why it is necessary to objectively interact with the quality of life of the subject. The main goal was to determine if there are differences between subacromial patients and asymptomatic patients regarding quality of life. METHODS: Transversal study carried out in the Talavera Integrated Area during the months of November 2016 to March2017. Participated a total of 92 subjects, 46 were symptomatic mating by age and sex with an asymptomatic sample and without joint pathology of the same size and health area. In both cases, the EQ-5D questionnaire was administered. The prevalence was calculated from the waiting list of traumatology physiotherapy in the year 2015. The SPSS statistical program was used, applying the T-test and the chi-square. RESULTS: The EQ-5D questionnaire obtained a standardized mean of 0.70 in the subacromial syndrome and 0.85 in the asymptomatic population (P=0.0001). The prevalence of impingement subacromial within shoulder pathology was 39.19%. CONCLUSIONS: Subacromial syndrome has a high prevalence within the shoulder pathology in the Rehabilitation Service and significantly interferes in the quality of life related to the health of the subject.

OBJETIVO: Existe una alta prevalencia del síndrome subacromial dentro de los pacientes con patología de hombro, en el cual el dolor y la tendencia a la cronificación son alguna de sus características más importantes. Por ello es necesario objetivar su interacción con la calidad de vida del sujeto. El objetivo principal del estudio fue determinar si existían diferencias en la calidad de vida entre sujetos con síndrome subacromial y asintomáticos. METODOS: Se realizó un estudio transversal en el Área Integrada de Talavera de la Reina (Toledo), durante los meses de noviembre de 2016 a marzo de 2017. Participaron un total de 92 sujetos, de los que 46 eran sintomáticos, apareándose por edad y sexo con una muestra asintomática y sin patología articular del mismo tamaño y área de salud. En ambos casos se les administró el cuestionario EQ-5D. La prevalencia se calculó a partir de la lista de espera de fisioterapia traumatológica del año 2015. Se utilizó el programa estadístico SPSS, empleándose la prueba T y la chi-cuadrado. RESULTADOS: El cuestionario EQ-5D obtuvo una media estandarizada de 0,70 en el síndrome subacromial y de 0,85 en la población asintomática (p=0,0001). La prevalencia del impingement subacromial dentro de la patología de hombro fue del 39,19%. CONCLUSIONES: El síndrome subacromial tiene una alta prevalencia dentro de la patología de hombro en el Servicio de Rehabilitación e interfiere significativamente en la calidad de vida relacionada con la salud del sujeto.

Calidad de vida relacionada con la salud en los pacientes diagnosticados de síndrome subacromial en el Área Integrada de Talavera / Health-related quality of life in patients diagnosed with subacromial syndrome in the Talavera Integrated Area

OBJETIVO: Existe una alta prevalencia del síndrome subacromial dentro de los pacientes con patología de hombro, en el cual el dolor y la tendencia a la cronificación son alguna de sus características más importantes. Por ello es necesario objetivar su interacción con la calidad de vida del sujeto. El objetivo principal del estudio fue determinar si existían diferencias en la calidad de vida entre sujetos con síndrome subacromial y asintomáticos. MÉTODOS: Se realizó un estudio transversal en el Área Integrada de Talavera de la Reina (Toledo), durante los meses de noviembre de 2016 a marzo de 2017. Participaron un total de 92 sujetos, de los que 46 eran sintomáticos, apareándose por edad y sexo con una muestra asintomática y sin patología articular del mismo tamaño y área de salud. En ambos casos se les administró el cuestionario EQ-5D. La prevalencia se calculó a partir de la lista de espera de fisioterapia traumatológica del año 2015. Se utilizó el programa estadístico SPSS, empleándose la prueba T y la chi-cuadrado. RESULTADOS: El cuestionario EQ-5D obtuvo una media estandarizada de 0,70 en el síndrome subacromial y de 0,85 en la población asintomática (p=0,0001). La prevalencia del impingement subacromial dentro de la patología de hombro fue del 39,19%. CONCLUSIONES: El síndrome subacromial tiene una alta prevalencia dentro de la patología de hombro en el Servicio de Rehabilitación e interfiere significativamente en la calidad de vida relacionada con la salud del sujeto

OBJECTIVE: There is a high prevalence of subacromial syndrome among patients with shoulder pathology, where the pain and tendency to chronification are some of its most important characteristics. This is why it is necessary to objectively interact with the quality of life of the subject. The main goal was to determine if there are differences between subacromial patients and asymptomatic patients regarding quality of life. METHODS: Transversal study carried out in the Talavera Integrated Area during the months of November 2016 to March2017. Participated a total of 92 subjects, 46 were symptomatic mating by age and sex with an asymptomatic sample and without joint pathology of the same size and health area. In both cases, the EQ-5D questionnaire was administered. The prevalence was calculated from the waiting list of traumatology physiotherapy in the year 2015. The SPSS statistical program was used, applying the T-test and the chi-square. RESULTS: The EQ-5D questionnaire obtained a standardized mean of 0.70 in the subacromial syndrome and 0.85 in the asymptomatic population (P=0.0001). The prevalence of impingement subacromial within shoulder pathology was 39.19%. CONCLUSIONS: Subacromial syndrome has a high prevalence within the shoulder pathology in the Rehabilitation Service and significantly interferes in the quality of life related to the health of the subject

Arginase I induction in macrophages, triggered by Th2-type cytokines, supports the growth of intracellular Leishmania parasites.

Leishmania spp. are intracellular protozoan parasites that invade and replicate within macrophages. In a previous report, we have demonstrated that the growth of intracellular amastigotes could be controlled by inhibition of arginase. This enzyme, induced in host cells by Th2 cytokines, synthesizes L-ornithine which can be used by parasites to generate polyamines and proliferate. In this study, we have designed experiments to better analyse the dependence of parasite proliferation on arginase induction in infected macrophages. Treatment of Leishmania major-infected BALB/c macrophages with interleukin (IL)-4, IL-10 or transforming growth factor-beta, which are all inducers of arginase I in murine macrophages, led to a proportional increase in the number of intracellular amastigotes. Moreover, parasite proliferation and arginase activity levels in macrophages from the susceptible BALB/c mice were significantly higher than those from infected C57BL/6 cells when treated with identical doses of these cytokines, indicating that a strong correlation exist between the permissibility of host cells to L. major infection and the induction of arginase I in macrophages. Specific inhibition of arginase by N(omega)-hydroxy-nor-L-arginine (nor-LOHA) reverted growth, while L-ornithine and putrescine promoted parasite proliferation, indicating that the parasite cell division depends critically on the level of L-ornithine available in the host. Therefore, arginase induction in the context of a Th2 predominant response might be a contributor to susceptibility in leishmaniasis.