RESUMO
Rectovaginal fistulae (RVF) are not uncommonly seen by the colorectal surgeon and gynaecologist, often debilitating for patients and typically managed with multiple operative procedures, achieving control rather than cure. Transvaginal repair is the least common surgical approach but has clear advantages and equivalent healing rates to other approaches. Here, we describe a simple, safe and effective flapless transvaginal technique for the repair of primary and recurrent low- and mid-level RVF of varying aetiology. We report 15 cases of RVF (nine recurrent) treated by this technique at a single UK centre. The healing rate was 67%. There were no major complications. Median follow-up was 48 months.
Assuntos
Fístula Retovaginal/cirurgia , Vagina/cirurgia , Adulto , Idoso , Cirurgia Colorretal , Feminino , Humanos , Pessoa de Meia-Idade , Cirurgiões , Resultado do Tratamento , Reino UnidoRESUMO
We conducted a survey to obtain the opinions of urogynaecologists regarding the National Institute for Health and Care Excellence or NICE 2013 urinary incontinence guideline and whether it would change their current practice. A closed format questionnaire was sent electronically to all members of the British Society of Urogynaecology or BSUG between January and March 2014. There were three major areas of disagreement. First, 70.2% of respondents disagreed that a multidisciplinary team review was necessary before invasive treatment for urinary incontinence. Second, 53.8% of respondents disagreed that preoperative urodynamic studies were not required in stress urinary incontinence diagnosed clinically. Third, 58.6% of respondents disagreed that oxybutynin, tolterodine and darifenacin should be used as first-line drug therapy for overactive bladder. The questionnaire demonstrates that there are significant concerns leading to more than a third of respondents not altering their current practice in line with the entire guideline.
Assuntos
Atitude do Pessoal de Saúde , Ginecologia/normas , Guias de Prática Clínica como Assunto , Incontinência Urinária/terapia , Urologia/normas , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Sociedades Médicas , Inquéritos e Questionários , Reino UnidoRESUMO
INTRODUCTION AND HYPOTHESIS: To determine if the classification of obstetric anal sphincter injuries (OASIs) affected clinical and functional outcome and to assess the need for follow-up of 3a tears in secondary care METHODS: Prospective data collection in 255 patients who sustained OASIs during repair with follow-up in a specialist clinic after 6 months. RESULTS: One hundred and thirty-two patients (51.7 %) sustained 3a tears, 81 (31.7 %) 3b tears, 27 (10.6 %) 3c tears and 15 (5.8 %) had 4th degree tears. Twenty-three patients (9 %) reported symptoms at 6-month follow-up. Eight patients reported anal incontinence of liquid or solid stool. Among patients who sustained 3a tears, 8 patients were symptomatic: 7 had urgency and 1 had flatus incontinence. None of the patients who sustained 3a tears reported incontinence of solid/liquid stool. There appears to be no correlation with scan findings and symptoms at follow up. Most patients are asymptomatic. Urgency of faeces is the commonest symptom. CONCLUSIONS: The vast majority of patients are asymptomatic. The necessity of seeing all these patients in secondary care for follow-up needs to be questioned. With effective primary care follow-up, there may be a place to follow up patients with 3a tears in the community during the routine 6-week postnatal check and refer the symptomatic patients to the hospital for further review.
Assuntos
Canal Anal/lesões , Incontinência Fecal/etiologia , Incontinência Fecal/cirurgia , Complicações do Trabalho de Parto , Adulto , Cirurgia Colorretal , Feminino , Seguimentos , Procedimentos Cirúrgicos em Ginecologia , Humanos , Gravidez , Estudos Retrospectivos , Atenção Secundária à Saúde , Resultado do TratamentoRESUMO
BACKGROUND: Overactive bladder (OAB) syndrome is a symptom complex affecting 12-14% of the UK adult female population. Symptoms include urinary urgency, with or without urgency incontinence, increased daytime urinary frequency and nocturia. OAB has a negative impact on women's social, physical, and psychological wellbeing. Initial treatment includes lifestyle modifications, bladder retraining, pelvic floor exercises and pharmacological therapy. However, these measures are unsuccessful in 25-40% of women (refractory OAB). Before considering invasive treatments, such as Botulinum toxin injection or sacral neuromodulation, most guidelines recommend urodynamics to confirm diagnosis of detrusor overactivity (DO). However, urodynamics may fail to show evidence of DO in up to 45% of cases, hence the need to evaluate its effectiveness and cost-effectiveness. FUTURE (Female Urgency, Trial of Urodynamics as Routine Evaluation) aims to test the hypothesis that, in women with refractory OAB, urodynamics and comprehensive clinical assessment is associated with superior patient-reported outcomes following treatment and is more cost-effective, compared to comprehensive clinical assessment only. METHODS: FUTURE is a pragmatic, multi-centre, superiority randomised controlled trial. Women aged ≥ 18 years with refractory OAB or urgency predominant mixed urinary incontinence, and who have failed/not tolerated conservative and medical treatment, are considered for trial entry. We aim to recruit 1096 women from approximately 60 secondary/tertiary care hospitals across the UK. All consenting women will complete questionnaires at baseline, 3 months, 6 months and 15 months post-randomisation. The primary outcome is participant-reported success at 15 months post-randomisation measured using the Patient Global Impression of Improvement. The primary economic outcome is incremental cost per quality-adjusted life year gained at 15 months. The secondary outcomes include adverse events, impact on other urinary symptoms and health-related quality of life. Qualitative interviews with participants and clinicians and a health economic evaluation will also be conducted. The statistical analysis of the primary outcome will be by intention-to-treat. Results will be presented as estimates and 95% CIs. DISCUSSION: The FUTURE study will inform patients, clinicians and policy makers whether routine urodynamics improves treatment outcomes in women with refractory OAB and whether it is cost-effective. TRIAL REGISTRATION: ISRCTN63268739 . Registered on 14 September 2017.
Assuntos
Bexiga Urinária Hiperativa , Urodinâmica , Adulto , Análise Custo-Benefício , Feminino , Humanos , Qualidade de Vida , Resultado do Tratamento , Bexiga Urinária Hiperativa/diagnóstico , Bexiga Urinária Hiperativa/terapia , Incontinência Urinária de Urgência/diagnóstico , Incontinência Urinária de Urgência/terapiaAssuntos
Biópsia por Agulha Fina/efeitos adversos , Hematúria/etiologia , Rim/patologia , Neoplasias Primárias Múltiplas/diagnóstico , Doença de von Hippel-Lindau/patologia , Adulto , Carcinoma de Células Renais/patologia , Humanos , Neoplasias Renais/patologia , Masculino , Neoplasias Pancreáticas/diagnóstico por imagem , Ultrassonografia de Intervenção/efeitos adversosRESUMO
OBJECTIVE: To investigate the effect of pregnancy and delivery on continence and to assess whether physical markers of collagen weakness can predict postpartum urinary and fecal incontinence (including incontinence of flatus). METHODS: In a prospective, longitudinal study in a London teaching hospital, 549 nulliparas were interviewed after 34 weeks' gestation and again 3 months postpartum regarding urinary and fecal symptoms before and during pregnancy and after delivery. Family histories of incontinence, prolapse, and collagen abnormalities were recorded also. Physical examination was done to assess markers of collagen weakness such as striae, hernia, varicose veins, and joint mobility. RESULTS: The prevalence of urinary incontinence before, during, and after pregnancy was 3.6%, 43.7%, and 14.6%, and rates of fecal incontinence were 0.7%, 6.0%, and 5.5%, respectively. Fecal urgency was more common in women who had spontaneous and instrument-assisted vaginal deliveries (n = 413) compared with cesareans (n = 131) (7.3% versus 3.1%; P = .046). Postnatal urinary or fecal dysfunction was not related to antenatal body mass index, smoking, race, striae, varicose veins, hemorrhoids, or family history of incontinence. Higher joint-mobility scores were associated with incontinence of flatus (P = .021) but not with other urinary or fecal symptoms. CONCLUSION: Although collagen weakness was previously implicated in the pathogenesis of incontinence, physical markers in this study could not predict postpartum urinary and fecal incontinence. Either those markers were not representative of collagen weakness, or a larger study with longer follow-up is necessary.
Assuntos
Incontinência Fecal/epidemiologia , Transtornos Puerperais/epidemiologia , Incontinência Urinária/epidemiologia , Adolescente , Adulto , Colágeno , Incontinência Fecal/diagnóstico , Incontinência Fecal/etiologia , Feminino , Humanos , Instabilidade Articular/complicações , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Gravidez , Complicações na Gravidez , Prevalência , Estudos Prospectivos , Transtornos Puerperais/diagnóstico , Transtornos Puerperais/etiologia , Fatores de Risco , Pele , Incontinência Urinária/diagnóstico , Incontinência Urinária/etiologia , Varizes/complicaçõesRESUMO
RATIONALE AND OBJECTIVES: The authors performed this study to determine whether exposure of renal calculi to radiographic contrast material has an effect on the attenuation values at computed tomography (CT) performed with varying collimation widths. MATERIALS AND METHODS: Renal calculi (23 stones of various composition) were scanned with 1-, 3-, and 10-mm collimation. Stones were then exposed to a solution of radiographic contrast material for 5 minutes, washed with water, and rescanned 36 hours later. The reproducibility of the CT attenuation measurements on different days was evaluated by obtaining measurements in a subset of 16 renal stones on 4 different days. RESULTS: There was no statistically significant change in attenuation after contrast material exposure at narrow collimation. At wider collimation, statistically significant increases were noted in both attenuation and standard deviation. A small amount of variability between readings was noted on different days, with a minimal increase in attenuation each day. Correlation between readings remained very high. CONCLUSION: Exposure of stones to a radiographic contrast material had a statistically significant effect on CT attenuation values only at wide collimation. This may be related to technical factors including volume averaging. Absence of an effect at narrow collimation suggests that the attenuation values of renal stones do not significantly change after exposure to contrast material.
Assuntos
Meios de Contraste , Cálculos Renais/diagnóstico por imagem , Tomografia Computadorizada por Raios X , HumanosRESUMO
RATIONALE AND OBJECTIVES: Urinary calculi are now commonly detected with helical computed tomography (CT), and it has been proposed that stone composition can be determined from CT attenuation values. However, typical scans are made with a beam collimation of 5 mm or more, resulting in volume averaging and reduction in accuracy of attenuation measurement. The authors tested a model for correction of errors in attenuation values, even at section widths larger than the width of the object. MATERIALS AND METHODS: Human urinary stones were scanned with helical CT at different beam collimation widths. A computer model was used to predict the effect of beam width and stone size on accuracy of measured attenuation. RESULTS: At 3-mm collimation, the model corrected the attenuation readings with an underestimation of 12% +/- 1 (compared with values at 1-mm collimation; 127 stones; diameters of 1.7-11.3 mm). With attenuation measured at 10-mm collimation, the model underestimated the true value by 34% +/- 3 (103 stones), with a significant negative correlation with stone diameter on magnitude of error (diameters of 3.0-11.3 mm). Correlation of data from patient scans with subsequent in vitro scanning of the same stones confirmed the validity of the model, but corrected in vivo scans consistently yielded lower values for the stones than in vitro. CONCLUSION: Volume averaging effects on attenuation in helical CT are predictable in vitro for urinary calculi--and presumably for other roughly spherical structures--as long as section width does not excessively exceed the diameter of the structure.
Assuntos
Tomografia Computadorizada por Raios X/métodos , Cálculos Urinários/diagnóstico por imagem , Simulação por Computador , Humanos , Técnicas In VitroRESUMO
BACKGROUND AND PURPOSE: Helical CT has become the preferred method for imaging urinary calculi, and so it would be useful if data from helical CT could also be used to predict the number of shockwaves (SWs) needed to break a given stone. METHODS AND MATERIALS: We measured the number of SWs required to comminute calcium stones in vitro. RESULTS: The SW requirement correlated with stone size (volume, weight, diameter) and with helical CT attenuation values when the scans were performed at 3-mm collimation. When CT scans were performed at 1-mm collimation, the number of SWs needed for comminution did not correlate with helical CT attenuation values. This result indicates that the correlation with 3-mm scans was attributable to volume-averaging effects, in which smaller stones yield smaller attenuation values. That is, attenuation values from helical CT at larger beam collimation widths contain information about stone size that can be exploited to predict the fragility of calcium stones. We observed that for calcium stones, the number of SWs to comminution was generally less than half the stone CT attenuation value in Hounsfield units. This "half-attenuation rule" predicted the number of SWs needed to complete fragmentation for 95% of calcium stones (24/24 calcium oxalate monohydrate, 13/13 hydroxyapatite, 8/10 brushite stones). CONCLUSION: This in vitro study suggests that it may be possible to predict effective SW dose using helical CT prior to lithotripsy.
Assuntos
Cálculos Renais/diagnóstico por imagem , Litotripsia/métodos , Tomografia Computadorizada por Raios X , Humanos , Litotripsia/efeitos adversos , Valor Preditivo dos TestesRESUMO
AIDS related cholangiopathy is a known clinical entity, but most cases described in literature are known cases of HIV infection who have presented with pain abdomen. AIDS cholangiopathy as the initial presentation of HIV infection is very rare. Here we report such a case.
Assuntos
Dor Abdominal/etiologia , Colangite/etiologia , Infecções por HIV/complicações , Adolescente , Infecções por HIV/diagnóstico , Humanos , MasculinoRESUMO
OBJECTIVE: Forty-five cases of advanced esophageal carcinoma were treated with Nd:YAG laser, to relieve dysphagia. METHODS: There were 36 males (80%) and nine female (20%) patients. The mean age of the patients was 55.87 years. Thirty-nine patients (86.6%) were found to have squamous cell carcinoma. Middle third growths were found to be most common (66.6%), followed by lower third (20%) and upper third (13.3%) tumours. The mean dysphagia grade at presentation was 3.33 with all 45 patients (100%) having dysphagia. RESULTS: After three months of treatment, the mean dysphagia grade improved to 1.73 with 39 patients being able to eat at least soft or solid food. Mean number of laser sessions required was 3.3. The mean weight of the patients also increased from 45.13 Kg to 47.71 Kg. Three patients developed an esophageal perforation (6.6%), out of whom two died. No other major complication was observed. CONCLUSION: Nd:YAG laser is thus an excellent means of palliation of distressful symptom of carcinoma of esophagus with expectable morbidity and mortality.
Assuntos
Carcinoma de Células Escamosas/cirurgia , Transtornos de Deglutição/prevenção & controle , Neoplasias Esofágicas/cirurgia , Terapia a Laser , Cuidados Paliativos , Carcinoma de Células Escamosas/complicações , Transtornos de Deglutição/etiologia , Neoplasias Esofágicas/complicações , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos ProspectivosRESUMO
An Indian case of Alport's syndrome who had association of keratoglobus and blue sclerae is described.
Assuntos
Rim/patologia , Nefrite Hereditária/diagnóstico , Esclera/anormalidades , Adulto , Diagnóstico Diferencial , Humanos , MasculinoRESUMO
We describe a case of post-operative bleeding after a posterior fascial defect repair. This was refractive to exploration and vaginal packing so laparotomy would have been necessary. Superselective cannulation demonstrated bleeding from a branch of the anterior pudendal artery which had crossed the midline making identification difficult during vaginal exploration. The bleeding vessel was embolised using a mixture of PVA300 and Spongistan gel foam and the bleeding ceased. The use of embolisation in the peri-operative phase is discussed.
Assuntos
Embolização Terapêutica/métodos , Hemorragia Pós-Operatória/terapia , Vagina/irrigação sanguínea , Angiografia , Artérias , Fasciotomia , Feminino , Seguimentos , Esponja de Gelatina Absorvível/uso terapêutico , Hemostáticos/uso terapêutico , Humanos , Pessoa de Meia-Idade , Álcool de Polivinil/uso terapêutico , Retocele/cirurgia , Incontinência Urinária por Estresse/cirurgia , Vagina/cirurgiaRESUMO
Endopelvic fascia contributes to the support of the uterus and vagina. There is increasing evidence that alteration in the fascial extracellular matrix may lead to weakening of the fascia and development of prolapse. Other workers have identified discrete defects in endopelvic fascia that can be rectified to cure prolapse. This paper reviews fascial defects and their repair.
Assuntos
Fáscia/anormalidades , Diafragma da Pelve/cirurgia , Fasciotomia , Feminino , Doenças dos Genitais Femininos/patologia , Humanos , Diafragma da Pelve/anormalidades , Prolapso , Incontinência Urinária/patologia , Doenças Urológicas/patologiaRESUMO
Voiding dysfunction in women is common, but is frequently undiagnosed until the patient presents with symptoms. The aetiology of voiding dysfunction includes the following, any of which may lead to acute or chronic disorders: obstructive causes; postsurgical conditions; neurological disorders; overdistension; inflammatory, pharmacological, psychogenic causes and learned voiding dysfunction; detrusor myopathy and urethral sphincter hypertrophy. Clinical assessment should include history, and general, neurological and pelvic examinations. Investigations may include uroflowmetry, ultrasound for residual urine and upper urinary tract dilatation, urodynamic assessment and electromyography. New surgical techniques to identify vesical branches of the pelvic nerves intraoperatively during radical hysterectomy have been shown to help prevent voiding dysfunction postoperatively. If acute retention occurs, then bladder drainage is the most important measure. Suprapubic catheters are superior to transurethral catheters if long-term voiding difficulties are expected. Whenever possible, patients with chronic retention should be taught clean intermittent self-catheterization. Depending on the cause, other possible treatment options include urethral dilatation, insertion of an intraurethral device, and neuromodulation. Voiding dysfunction in women is still poorly understood. Prompt management of acute retention is essential, and clean intermittent self-catheterization remains the most effective therapy for chronic retention.
Assuntos
Retenção Urinária , Feminino , Humanos , Retenção Urinária/etiologia , Retenção Urinária/fisiopatologia , Retenção Urinária/terapiaRESUMO
OBJECTIVE: To determine whether periurethral collagen is an effective, safe and practical day-case procedure to control genuine stress incontinence (urethral sphincter incompetence) in the elderly female. DESIGN: Prospective longitudinal study using subjective and objective outcome measures with long term follow up. SETTING: A teaching hospital tertiary referral centre. SAMPLE: Thirty-two women over 65 years of age with a urodynamic diagnosis of genuine stress incontinence. RESULTS: At one year, 22 women (79%) were subjectively cured or improved, and 14 (50%) were objectively cured; at two years, 18 (69%) and 14 (54%), respectively. Symptoms of urgency, urge incontinence, frequency and nocturia improved, while voiding difficulty remained unchanged. Brief urinary retention was encountered in seven women. No long term side effects or complications were encountered. Urodynamic studies suggest that collagen works by preventing premature bladder neck opening through physical stress, rather than by obstruction. This would account for the slight increase in functional urethral length. CONCLUSIONS: Contigen collagen is a simple and effective day case procedure as an alternative to major surgery and is without significant morbidity or complication. It is ideal for the elderly.
Assuntos
Colágeno/uso terapêutico , Incontinência Urinária por Estresse/terapia , Idoso , Idoso de 80 Anos ou mais , Assistência Ambulatorial , Colágeno/administração & dosagem , Colágeno/efeitos adversos , Feminino , Humanos , Injeções , Estudos Longitudinais , Estudos Prospectivos , Incontinência Urinária por Estresse/fisiopatologia , Micção , UrodinâmicaRESUMO
OBJECTIVE: To assess the role of urodynamics in the prediction and assessment of outcome and analysis of the mechanism of cure for stress incontinence using periurethral collagen as our treatment model. DESIGN: Prospective longitudinal study. SETTING: A teaching hospital tertiary referral centre. PATIENTS: Sixty women with genuine stress incontinence. RESULTS: The objective cure rate was 54% (n = 54) at 12 months. Subtracted cystometry, urethral electrical conductivity and bladder neck excursion measurements did not predict cure. A low pre-injection maximum urethral closure pressure adversely affects outcome (31 cmH2O (success) vs 19 cmH2O (failure), P = 0.004); all women with a maximum urethral closure pressure > 39 cmH2O were rendered dry. Urethral pressure profilometry can analyse mechanism of cure. Total profile length, stress maximum urethral closure pressure, stress functional urethral length and pressure transmission ratio in the first quarter of urethral length were increased in successful cases (P < 0.05), and rest maximum urethral and maximum urethral closure pressures, area under rest profile and pressure transmission ratio in the second quarter of urethral length were increased in failed cases (P < 0.02). CONCLUSIONS: In successful cases the increased area and pressure transmission ratio in the first quarter of the functional urethral length suggest that collagen placement occurs at the bladder neck or proximal urethra. Cure appears to be due to prevention of bladder neck opening during stress and not obstruction. In addition the cephalad elongation of the urethra caused by collagen probably accounts for the increased abdominal pressure transmission in the first quarter of the urethra. In failures, there is an increased length and increased area to peak pressure suggesting collagen is deposited more distally. This study confirms the role of certain urethral pressure profilometry variables in the prediction and analysis of mechanism of cure.
Assuntos
Colágeno/uso terapêutico , Incontinência Urinária por Estresse/terapia , Urodinâmica , Adulto , Idoso , Idoso de 80 Anos ou mais , Colágeno/administração & dosagem , Feminino , Seguimentos , Humanos , Estudos Longitudinais , Pessoa de Meia-Idade , Pressão , Estudos Prospectivos , Resultado do Tratamento , Incontinência Urinária por Estresse/fisiopatologiaRESUMO
For centuries the structure and function of the pelvic floor and anal sphincter have remained enigmatic. Great strides made in new imaging techniques over the last decade has enabled a better understanding of this complex and dynamic structure. We can now explore pelvic floor dysfunction.