Organ preservation in patients with advanced laryngeal tumours. Results of induction chemotherapy versus chemoradiotherapy in actual clinical practice. / Preservación de órgano en pacientes con tumores avanzados de laringe. Resultados de la quimioterapia de inducción versus quimio-radioterapia en la práctica clínica real.

INTRODUCTION AND OBJECTIVES: A high percentage of patients with locally advanced larynx carcinomas are candidates for inclusion in organ preservation protocols. The objective of this study is to compare the results of two schemes of preservation, induction chemotherapy versus chemoradiotherapy, in patients with locally advanced larynx carcinomas in the context of actual clinical practice. METHODS: Our retrospective study included 157 patients with locally advanced tumours of the larynx (T3-T4) treated with induction chemotherapy (n = 121) or chemoradiotherapy (n = 36). RESULTS: From 121 patients who began treatment with induction chemotherapy, 6 died due to toxicity, 37 were treated with surgery, and 78 completed the preservation scheme; 36 patients received treatment with chemoradiotherapy. There were no significant differences in 5-year disease-specific survival between both treatments: 68.9% in induction chemotherapy versus 75.7% in chemoradiotherapy (p = 0.259). In 45.9% of patients the laryngeal function was preserved. Patients treated with chemoradiotherapy had a tendency to have better 5-year laryngeal dysfunction-free survival than patients treated with induction chemotherapy (55.6% versus 44.8%, p = 0.079). CONCLUSION: Patients included in a protocol of organ preservation achieved a 5-year laryngeal dysfunction-free survival of 45.9%. There were no significant differences in disease-specific survival among patients treated with induction chemotherapy or chemoradiotherapy.

Oncological results of salvage laryngectomy in patients with laryngeal carcinoma. / Resultados oncológicos de la laringectomía de rescate en pacientes con carcinomas escamosos de laringe.

OBJECTIVE: To analyse the oncological results of a salvage total laryngectomy in patients with a laryngeal carcinoma. MATERIAL AND METHODS: Retrospective review of a cohort of 241 patients treated with a salvage laryngectomy after a local recurrence. The initial treatment received by these patients was radiotherapy (n=201, 83.4%), chemoradiotherapy (n=19, 7.9%), and partial surgery (n=21, 8.7%), RESULTS: Total laryngectomy as salvage treatment achieved local control of the disease in 81.3% of cases, with a 5-year specific survival of 65.3%. The variables related with specific survival in a univariate analysis were the location of the primary tumour, the local extension of the initial tumour and of the recurrence, the resection margins, and the pathological status of the neck dissections. According to the results of a multivariate analysis, the variables related to specific survival were the status of the resection margins, the presence of simultaneous regional recurrence, and the local extension of the recurrence. CONCLUSION: The 5-year specific survival of patients treated with a salvage laryngectomy was 65.3%. The variables related with the control of the disease were the status of the resection margins, the presence of simultaneous regional recurrence and the local extension of the recurrence.

Efficacy and safety of fluocinolone acetonide 0.025% otic solution in patients with otic eczema: a randomized, double-blind, placebo-controlled clinical trial.

Objectives To assess the efficacy and safety of fluocinolone acetonide 0.025% otic solution versus placebo in treating patients with otic eczema. Methods In this multicentre, randomized, double-blind, parallel-group phase 3 clinical trial, conducted at 12 Spanish centres between March 2012 and March 2013, patients received fluocinolone acetonide 0.025% or placebo otic solution twice daily for 7 days (days 1-7) with an 8-day follow-up (days 9-15). Outcome measures included change in itching from baseline (day 1) to study days 4-8 and 9-15, and change in otoscopic signs (erythema, oedema, and scaling) from baseline to the end of treatment (day 8) and end of follow-up (day 15). Results Patients treated with fluocinolone acetonide 0.025% (n = 66), as compared with placebo-treated patients (n = 69), showed significantly higher reductions in itching from baseline to study days 4-8 and 9-15, and in individual and global otoscopic signs from baseline to the end of treatment (day 8) and end of follow-up (day 15). Incidence and severity of adverse events was similar between the fluocinolone and placebo groups. Conclusions Fluocinolone acetonide 0.025% otic solution, administered twice daily for 7 days, is an effective and safe treatment for otic eczema.

Preservación de órgano en pacientes con tumores avanzados de laringe. Resultados de la quimioterapia de inducción versus quimio-radioterapia en la práctica clínica real / Organ preservation in patients with advanced laryngeal tumours. Results of induction chemotherapy versus chemoradiotherapy in actual clinical practice

Introducción y objetivos: Un porcentaje elevado de pacientes con carcinomas localmente avanzados de laringe son candidatos a ser incluidos en protocolos de preservación de órgano. El objetivo del presente estudio es comparar los resultados de dos esquemas de preservación, quimioterapia de inducción versus quimio-radioterapia, en pacientes con carcinomas de laringe localmente avanzados en un contexto de práctica clínica real.MétodosEstudio retrospectivo realizado en 157 pacientes con tumores localmente avanzados de laringe (T3-T4) tratados con quimioterapia de inducción (n = 121) o quimio-radioterapia (n = 36).ResultadosDe los 121 pacientes que iniciaron tratamiento con quimioterapia de inducción, seis fallecieron como consecuencia de toxicidad, 37 fueron tratados con cirugía y 78 completaron el esquema de preservación; 36 pacientes recibieron un tratamiento inicial con quimio-radioterapia. No existieron diferencias significativas en la supervivencia específica a los cinco años en función de que los pacientes iniciasen un tratamiento con quimioterapia de inducción o quimio-radioterapia (68,9% versus 75,7%, p = 0,259). Un 45,9% de los pacientes consiguió una preservación de la función laríngea. Los pacientes tratados con quimio-radioterapia tuvieron una tendencia a conseguir una supervivencia libre de pérdida de la función laríngea a los cinco años superior a la de los pacientes tratados con quimioterapia de inducción (55,6% versus 44,8%, p = 0,079).ConclusiónLos pacientes incluidos en un protocolo de preservación consiguieron una supervivencia libre de disfunción laríngea a los cinco años del 45,9%. No se observaron diferencias significativas en la supervivencia específica entre los pacientes tratados con quimioterapia de inducción o quimio-radioterapia. (AU)

Introduction and objectives: A high percentage of patients with locally advanced larynx carcinomas are candidates for inclusion in organ preservation protocols. The objective of this study is to compare the results of two schemes of preservation, induction chemotherapy versus chemoradiotherapy, in patients with locally advanced larynx carcinomas in the context of actual clinical practice.MethodsOur retrospective study included 157 patients with locally advanced tumours of the larynx (T3-T4) treated with induction chemotherapy (n = 121) or chemoradiotherapy (n = 36).ResultsFrom 121 patients who began treatment with induction chemotherapy, 6 died due to toxicity, 37 were treated with surgery, and 78 completed the preservation scheme; 36 patients received treatment with chemoradiotherapy. There were no significant differences in 5-year disease-specific survival between both treatments: 68.9% in induction chemotherapy versus 75.7% in chemoradiotherapy (p = 0.259). In 45.9% of patients the laryngeal function was preserved. Patients treated with chemoradiotherapy had a tendency to have better 5-year laryngeal dysfunction-free survival than patients treated with induction chemotherapy (55.6% versus 44.8%, p = 0.079).ConclusionPatients included in a protocol of organ preservation achieved a 5-year laryngeal dysfunction-free survival of 45.9%. There were no significant differences in disease-specific survival among patients treated with induction chemotherapy or chemoradiotherapy. (AU)

Resultados oncológicos de la laringectomía de rescate en pacientes con carcinomas escamosos de laringe / Oncological results of salvage laryngectomy in patients with laryngeal carcinoma

OBJETIVO: Analizar los resultados oncológicos conseguidos con una laringectomía total como cirugía de rescate en pacientes con carcinomas escamosos de la laringe. MATERIAL Y MÉTODOS: Revisión retrospectiva de una cohorte de 241 pacientes tratados con una laringectomía total tras una recidiva local de la enfermedad. El tratamiento inicial recibido por los pacientes fue de radioterapia (n = 201; 83,4%), quimiorradioterapia (n = 19; 7,9%), o una cirugía parcial (n = 21; 8,7%). RESULTADOS: La laringectomía total como cirugía de rescate consiguió el control local de la enfermedad en el 81,3% de las ocasiones, con una supervivencia específica a los 5 años del 65,3%. Las variables relacionadas con la supervivencia específica en un estudio univariante fueron la localización del tumor, la extensión local del tumor inicial y de la recidiva, los márgenes de resección, y el estatus patológico de los vaciamientos cervicales. De acuerdo con los resultados de un análisis multivariante, las variables que se relacionaron con la supervivencia fueron el estatus de los márgenes de resección, la presencia de una recidiva regional simultánea y la extensión local de la recidiva. CONCLUSIONES: La supervivencia específica a los 5 años de los pacientes tratados con una laringectomía total de rescate fue del 65,3%. Las variables que se relacionaron con el control final de la enfermedad fueron el estatus de los márgenes de resección, la presencia de una recidiva regional simultánea y la extensión local de la recidiva

OBJECTIVE: To analyse the oncological results of a salvage total laryngectomy in patients with a laryngeal carcinoma. MATERIAL AND METHODS: Retrospective review of a cohort of 241 patients treated with a salvage laryngectomy after a local recurrence. The initial treatment received by these patients was radiotherapy (n = 201, 83.4%), chemoradiotherapy (n=19, 7.9%), and partial surgery (n = 21, 8.7%), RESULTS: Total laryngectomy as salvage treatment achieved local control of the disease in 81.3% of cases, with a 5-year specific survival of 65.3%. The variables related with specific survival in a univariate analysis were the location of the primary tumour, the local extension of the initial tumour and of the recurrence, the resection margins, and the pathological status of the neck dissections. According to the results of a multivariate analysis, the variables related to specific survival were the status of the resection margins, the presence of simultaneous regional recurrence, and the local extension of the recurrence. CONCLUSION: The 5-year specific survival of patients treated with a salvage laryngectomy was 65.3%. The variables related with the control of the disease were the status of the resection margins, the presence of simultaneous regional recurrence and the local extension of the recurrence

Mastoiditis aguda: revisión casuística / Acute mastoiditis: review of a single center experience

Fundamento. La incidencia de mastoiditis aguda y la necesidad de tratamiento quirúrgico disminuyeron con la introducción del tratamiento antibiótico. Posteriormente se ha mantenido estable o podría haber aumentado por cambios de la sensibilidad microbiana. Objetivo. Conocer la presentación clínica y evolución de las mastoiditis agudas tratadas en nuestro centro. Método. Revisión retrospectiva de 19 mastoiditis agudas ingresadas entre enero de 1998 y enero de 2002. Resultados. La edad media fue de 35 meses. Todos iban a guarderia o colegio. 7 (36.8%) tenían otitis medias agudas recurrentes. 13 (68.4%) recibieron antibióticos el mes anterior. 17 (89.5%) presentaban otitis aguda. 13 (68.4%) manifestaban fiebre, 18 (94.7%) otalgia o irritabilidad, 9 (47.4%) supuración, todos tímpano alterado y eritema postauricular, 15 (78.9%) tumefacción postauricular y 17 (89.5%) pabellón desplazado. El recuento fue superior a 15000 leucocitos/mm3 en 4, la proteína C reactiva superior a 60 mg/L en 7 y el hemocultivo negativo en 15 de 17. La tomografía computerizada confirmó el diagnóstico, 2 con osteitis y 2 con absceso retroauricular. El antibiótico más utilizado fue la cefotaxima. 2 requirieron punción timpánica (10.5%), 8 drenaje transtimpánico (42.1%), 2 mastoidectomía (10.5%) y 9 (47.4%) ningun abordaje. Conclusiones. La mastoiditis aguda se da sobre todo en menores de 6 años, no siempre con otitis media aguda recurrente, que han recibido antibióticos el mes previo. Habitualmente es complicación de una otitis media aguda. El diagnóstico es clínico. La tomografía computerizada determina la extensión. El tratamiento es antibiótico endovenoso y drenaje de la colección purulenta (AU)

Background. The incidence of acute mastoiditis and the need for surgical treatment declined significantly after the introduction of antibiotics and stabilized subsequently. However, given the changes in bacterial sensitivities, the incidence of acute mastoiditis may be rising. Objective. To describe the clinical characteristics, treatment, and outcome of patients diagnosed with acute mastoiditis in our institution. Method. Retrospective review of 19 patients with acute mastoiditis seen in our institution between January 1998 and January 2002. Results. Mean age at diagnosis was 35 months. All patients were attending either daycare or school. Seven patients (36.8%) had recurrent acute otitis media. Thirteen patients (68.4%) had received an antibiotic during the previous month. Seventeen patients (89.5%) had concomitant acute otitis media, 13 (68.4%) had fever, 18 (94.7%) had otalgia or irritability, 9 (47.4%) had otorrhea, 15 (78.9%) had retroauricular swelling, 17 (89.5%) had auricular displacement, and ll patients had abnormal tympanic membrane and retroauricular erythema. White blood cell count was greater than 15,000/cumm in 4 patients, C-Reactive protein was greater than 60 mg/L in 7 patients, and blood culture was negative in 15 of 17 patients in whom blood culture was obtained. Computorized tomography confirmed the diagnosis of mastoiditis in all patients. In two patients, there was evidence of osteitis, and in 2 patients a retroauricular abscess was noted. The most frequent antibiotic prescribed was cefotaxime. Two patients (10.5%) required myringotomy, 8 patients (42.1%) required the placement of tympanic drainage tubes, 2 patients (10.5%) required mastoidectomy, and 9 patients (47.4%) did not require any surgical intervention. Conclusions. Acute mastoiditis is diagnosed typically in young children (< 6 years) that have a recent history of antibiotic administration, as a complication of acute otitis media. However, it is not always associated with recurrent acute otitis media.The diagnosis is usually clinical, and computorized tomography may help in the definition of the extension of the infection. The treatment is with intravenous antibiotics and surgical drainage of any abscesses (AU)