Detalhe da pesquisa
1.
Itk kinase inhibitors: initial efforts to improve the metabolical stability and the cell activity of the benzimidazole lead.
Bioorg Med Chem Lett
; 18(20): 5537-40, 2008 Oct 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18819794
2.
5-Aminomethyl-1H-benzimidazoles as orally active inhibitors of inducible T-cell kinase (Itk).
Bioorg Med Chem Lett
; 18(20): 5541-4, 2008 Oct 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18823779
3.
Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk).
Bioorg Med Chem Lett
; 18(20): 5545-9, 2008 Oct 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18819799
4.
The discovery of orally active triaminotriazine aniline amides as inhibitors of p38 MAP kinase.
J Med Chem
; 47(25): 6283-91, 2004 Dec 02.
Artigo
Inglês
| MEDLINE | ID: mdl-15566298
5.
Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists.
Bioorg Med Chem
; 14(8): 2725-46, 2006 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-16377201
6.
The synthesis and SAR of 2-amino-pyrrolo[2,3-d]pyrimidines: a new class of Aurora-A kinase inhibitors.
Bioorg Med Chem Lett
; 16(22): 5778-83, 2006 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-16949284
7.
Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors.
Bioorg Med Chem Lett
; 16(1): 123-8, 2006 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-16236500
8.
Identified a morpholinyl-4-piperidinylacetic acid derivative as a potent oral active VLA-4 antagonist.
Bioorg Med Chem Lett
; 15(1): 41-5, 2005 Jan 03.
Artigo
Inglês
| MEDLINE | ID: mdl-15582407
9.
Comprehensive survey of combinatorial library synthesis: 2005.
J Comb Chem
; 8(5): 597-635, 2006.
Artigo
Inglês
| MEDLINE | ID: mdl-16961395