1.
Bioorg Med Chem Lett
; 19(22): 6275-9, 2009 Nov 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19819140
RESUMO
The same two major CYP mediated metabolites of DG-051 were produced in the presence of rat, dog, monkey and human liver microsomes. Their respective structures were hypothesized based on mass spectrometry data correlated with the parent structure and confirmed by comparison with authentic synthetic samples. The number of regioisomers synthesized as candidates for metabolite M1 was narrowed down using a metabolic study of a selectively deuterated DG-051 analogue.