A planetary health perspective on the translation of climate change research into public health policy and practice: A scoping review protocol.

BACKGROUND: Climate Change (CC) emanating from anthropocentric human activities is a great threat to the quality of human life and well-being worldwide. The translation of CC research evidence can play a critical role in promoting the formulation of climate-sensitive policies to equip public health systems for CC-associated disaster preparedness, response, and management. This scoping review seeks to explore knowledge translation approaches for promoting, the uptake, and use of CC research evidence in public health policy and practice. METHODS: This scoping review will be conducted according to the guidelines of Arksey and O'Malley. A search strategy will be developed for published articles in PubMed, CINAHL, and Scopus databases and for grey literature in the World Health Organization, Planetary Health Alliance, and the University of the Western Cape repositories. DISCUSSION: The proposed scoping review will gather existing evidence on the relationship between knowledge translation, CC research, and public health decision-making. This will provide insights into research and practice gaps, and recommendations will be made to ensure effective knowledge translation for CC related decision-making.

Perceptions, experiences, and motivation of COVID-19 vaccine trial participants in South Africa: a qualitative study.

BACKGROUND: The informed consent process is an important step in conducting ethical clinical trials, as it ensures that research participants are aware of their rights and responsibilities in clinical trials. This study explored participants' perceptions, experiences and the factors motivating their participation in a COVID-19 vaccine trial in South Africa. METHODS: This descriptive qualitative study was conducted among twenty-five adult participants (18 to 64 years old) who participated in a COVID-19 vaccine trial in South Africa. Three focus group discussions and fifteen semi-structured interviews were carried out. Data were collected at a Clinical Research Site located in Prince Mshiyeni Memorial Hospital, in Umlazi Township, Durban, South Africa, where the COVID-19 vaccine trial participants were initially enrolled. Data were analysed iteratively using a thematic analysis approach. RESULTS: Four key findings emerged: 1) Participants who experienced an event (such as tested positive for COVID-19) during the clinical trial were more likely to talk about the informed consent more thoroughly compared to the other participants. 2) Participants understood the purpose of informed consent process better when it was repeated multiple times throughout the course of the trial. 3) Where participants did not recall or understand various elements of the informed consent, participants were likely to create their own interpretations. 4) Factors influencing participations in trials were reimbursement for participation, access to health care, protection of family members, and ability to socialize without fear of COVID-19. CONCLUSION: Overall, the findings show that the informed consent process should be regarded as an ongoing process rather than a once-off event that only happens at the start of a clinical trial. An understanding of participants' perspectives, experiences, and motivations for participating in clinical trials, can help trial staff strengthen the consent documents and processes.

A mapping exercise to identify the strengths, and gaps in knowledge translation activities at Cochrane South Africa.

Knowledge translation (KT) is a set of activities or processes for synthesising, disseminating, and applying research evidence in decision-making for the benefit of society. For KT to be successful, it is paramount for researchers to play an active role in encouraging evidence uptake and use in decision-making. We carried out a mapping exercise and interviews with research cluster heads at Cochrane South Africa (CSA) of the KT activities and processes being implemented (or are planned for implementation). We organized the mapping and interview results according to the KT themes described in the Cochrane KT framework. The KT framework comprises six themes, namely, (i) prioritization and co-production of research evidence; (ii) building a sustainable infrastructure for knowledge translation; (iii) engaging with audiences for knowledge exchange or dialogue; (iv) packaging, communication and dissemination which entails disseminating research to users; (v) building audience capacity to use evidence or training activities; and (vi) advocacy or improving the culture of using evidence. Through the mapping exercise and interviews, we learned that CSA researchers excelled in implementing activities and processes linked to most of the KT themes, including producing different types of systematic reviews and providing reliable evidence for health decision-making. Cochrane South Africa (CSA) researchers are also involved in mentoring and training postgraduate students and various health decision-makers (e.g., health professionals, guideline panels and policy-makers). While they excel in the above-mentioned activities, "packaging, communication, and dissemination of research evidence" (theme iv) was identified as an area of improvement.

Contextual and Psychosocial Factors Influencing the Use of Safe Water Sources: A Case of Madeya Village, uMkhanyakude District, South Africa.

Background: Schistosomiasis is a public health problem that affects over 240 million people worldwide. It is mostly prevalent in tropical and sub-tropical areas among communities with limited access to clean water and adequate sanitation. This study was conducted in uMkhanyakude District in rural South Africa, where water resources are limited. In this community, individuals frequently come into contact with freshwater bodies for various reasons. The objective of the study was to identify critical contextual and psychosocial factors for behaviour change to reduce risk of schistosomiasis transmission in Madeya Village, uMkhanyakude district. Methods: Structured household interviews were held with 57 primary caregivers to assess their thoughts and attitudes towards collecting water from a safe source. We used the Risk, Attitude, Norm, Ability, and Self-regulation model (RANAS) to estimate the intervention potential for each factor by analysing differences in means between groups of current performers and nonperformers who use safe water sources. Results: The subscale vulnerability belonging to the risk factor on the RANAS was scored as low. Furthermore, attitudinal factors towards the use of safe water sources were found to be low. Ability factors (confidence in performance and confidence in recovery) towards the use of safe water sources were low as well, indicating that these factors should be the target of the intervention in the study area. Discussion: Based on this study, it is recommended that a community-based empowerment intervention strategy it appropriate. The strategy should prompt behavioural practice and public commitment, use persuasive language to boost self-efficacy and target younger low-income caregivers between 18 and 35 years of age.