Pneumothorax after pneumonectomy: surgery with successful double lobe ventilation.

Contralateral pneumothorax is potentially lethal in patients who have undergone pneumonectomy. There are few reports about the diagnosis and treatment of this situation. This is a report of our experience with selective lobar ventilation of the middle and lower lobes using a guidewire and a bronchial blocker in the right upper bronchus of a patient who had previously undergone left pneumonectomy.

[Fentanyl shows different effects by administration routes on bispectral index during spinal anesthesia in patients undergoing cesarean section].

BACKGROUND: Spinal anesthesia using a local anesthetic with fentanyl has been reported to induce sedation. We previously reported that the bispectral index (BIS) value was significantly decreased by spinal anesthesia using only bupivacaine and fetanyl after cesarean delivery. In the present study, we studied the effect of different fentanyl administration routes on BIS values during spinal anesthesia for cesarean section. METHODS: Forty-six women scheduled for cesarean section were allocated into five-groups according to the route of fentanyl administration and amount of local anesthetic: intrathecal 0.5% isobaric bupivacaine 2.5 ml plus fentanyl 20 microg (n = 11), intrathecal 0.5% isobaric bupivacaine 2.5 ml plus intravenous fentanyl 100 microg (n = 12), intrathecal 0.5% isobaric bupivacaine 2.5 ml plus epidural fentanyl 100 microg (n = 8), intrathecal 0.5% isobaric bupivacaine 2.5 ml (n = 8), and intrathecal 0.5% isobaric bupivacaine 3.0 ml (n = 7). BIS values were recorded during anesthesia. RESULTS: BIS values in intrathecal fentanyl group were lower than those of other groups (P = 0.03). The cumulative duration of BIS values 80 and below 80 was longer in the intrathecal fentanyl group than those of other groups (P = 0.004). CONCLUSION: The BIS value was significantly decreased only by intrathecal fentanyl for cesarean section.

[Anesthetic management of pneumonorrhaphy for one-lung patient].

Selective immobilisation of the lobes of the lungs with a bronchial blocker is sometimes a challenge for anesthesiologists. A pneumonorrhaphy was planned in a patient who had had undergone left pneumectomy, and selective immobilisation of the right upper lobe was requested. The initial attempt to place the cuff of a bronchial blocker was unsuccessful. We inserted a urethral guide-wire through fiberoptic bronchoscope and positioned the tip at the orifice of the right upper bronchus. We then threaded the bronchial blocker through the guidewire and placed the cuff at the right upper bronchus. The right upper lobe was successfully collapsed, which greatly facilitated the surgical procedure. The method is easy, fast, and safe and should be considered when difficulty in placement of the bronchial blocker is encountered.

[Appropriate dose of isobaric bupivacaine with fentanyl in spinal anesthesia for cesarean section].

BACKGROUND: Spinal anesthesia combined with fentanyl is commonly used for cesarean section. We studied the appropriate dose of isobaric bupivacaine for spinal anesthesia when combined with a fixed dose of 20 microg fentanyl. METHODS: Forty-seven women scheduled for cesarean section were allocated into four-groups according to the dose of 0.5% isobaric bupivacaine with 20 microg fentanyl; 1.0 ml (n=5), 1.5 ml (n=11), 2.0 ml (n=11), and 2.5 ml (n=20). RESULTS: The requirement of epidural anesthesia for pain relief or muscle relaxant was less in the 2.0 ml and 2.5 ml groups than the other groups. However, dyspnea due to high spinal anesthesia developed in 3 subjects out of 20 in the 2.5 ml group. CONCLUSIONS: Two ml of 0.5% isobaric bupivacaine was the most appropriate dose for cesarean section, when combined with 20 microg of fentanyl.

[Undetachable connection between a reinforced endotracheal tube and L connector].

We anesthesiologists sometimes encounter a situation where we difficulty detaching an L connector from an endotracheal tube. However, to our knowledge, there is no paper wich describes complete inability of detaching the connector from the tube. A 33-year-old female patient was scheduled for jaw joint arthroplasty and manipulation of synarthrophysis after the previous intermaxillary fixation. After midazolam and fentanyl administration, the trachea was intubated with a reinforced endotracheal tube (Mallinckrodt Inc., St. Louis, USA) through the right nostril with the aid of a bronchofiberscope. When we tried to move the anesthesia machine, we could not detach the L connector from the endotracheal tube by any means. Furthermore, because a slip-joint is glued to a reinforced endotracheal tube, it was impossible to separate them. The patient had locklaw, and therefore to avoid reintubation, we scraped off the surface of the L connector, and the connector was successfully detached. Although slip-joints of tracheal tubes and L connectors are standardized with JIS and ISO, their connection is not necessarity good due to the difference of makers and/or a tolerance of products. We think that Tracheostomy Wedge (Portex Inc., New Hampshire, USA) is useful for detaching the cconnection.

Pentobarbital inhibits ketamine-induced dopamine release in the rat nucleus accumbens: a microdialysis study.

UNLABELLED: Dopamine release in the nucleus accumbens (NAC) plays a crucial role in the actions of various psychotropic and addictive drugs. Ketamine and barbiturates have psychotropic effects and addictive properties, but barbiturates prevent ketamine's psychotomimetic effects. We investigated the effects of ketamine and pentobarbital on dopamine release in the NAC. A microdialysis probe was implanted in the NAC in 35 rats, which were randomly assigned to seven groups: a normal saline intraperitoneal injection (ip) group, 50 and 100 mg/kg of ketamine ip groups, 25 and 50 mg/kg of pentobarbital ip groups, and a normal saline or 25 mg/kg of pentobarbital ip followed by 50 mg/kg of ketamine ip groups. Perfusate samples were collected every 20 min, and dopamine concentration was measured by high-performance liquid chromatography. Ketamine at doses of 50 mg/kg and 100 mg/kg significantly increased dopamine release in the NAC. Conversely, pentobarbital significantly decreased dopamine release in the NAC and inhibited the ketamine-induced dopamine release. These data suggest that the dopamine release in the NAC may be involved in ketamine-induced, but not barbiturate-induced, psychotropic effects and addiction. Inhibition of ketamine-induced dopamine release by barbiturates may be a mechanism by which they prevent ketamine emergence reactions. IMPLICATIONS: Ketamine increased dopamine release in the nucleus accumbens, which was inhibited by pentobarbital. The mesolimbic dopamine system may be involved in the psychotomimetic effects of ketamine, and the suppression of ketamine emergence reactions by barbiturates may be because of the inhibition of ketamine-induced dopamine release in the nucleus accumbens.