Detalhe da pesquisa
1.
Phosphorylation alters the mechanical stiffness of a model fragment of the dystrophin homologue utrophin.
J Biol Chem
; 299(2): 102847, 2023 02.
Artigo
Inglês
| MEDLINE | ID: mdl-36587764
2.
Enhancing interaction of actin and actin-binding domain 1 of dystrophin with modulators: Toward improved gene therapy for Duchenne muscular dystrophy.
J Biol Chem
; 298(12): 102675, 2022 12.
Artigo
Inglês
| MEDLINE | ID: mdl-36372234
3.
Allostery governs Cdk2 activation and differential recognition of CDK inhibitors.
Nat Chem Biol
; 17(4): 456-464, 2021 04.
Artigo
Inglês
| MEDLINE | ID: mdl-33526892
4.
Direct detection of the myosin super-relaxed state and interacting-heads motif in solution.
J Biol Chem
; 297(4): 101157, 2021 10.
Artigo
Inglês
| MEDLINE | ID: mdl-34481842
5.
Mavacamten stabilizes an autoinhibited state of two-headed cardiac myosin.
Proc Natl Acad Sci U S A
; 115(32): E7486-E7494, 2018 08 07.
Artigo
Inglês
| MEDLINE | ID: mdl-30018063
6.
Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states.
Proc Natl Acad Sci U S A
; 115(51): E11894-E11903, 2018 12 18.
Artigo
Inglês
| MEDLINE | ID: mdl-30518564
7.
A posttranslational modification of the mitotic kinesin Eg5 that enhances its mechanochemical coupling and alters its mitotic function.
Proc Natl Acad Sci U S A
; 115(8): E1779-E1788, 2018 02 20.
Artigo
Inglês
| MEDLINE | ID: mdl-29432173
8.
Converter domain mutations in myosin alter structural kinetics and motor function.
J Biol Chem
; 294(5): 1554-1567, 2019 02 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30518549
9.
Heart failure drug changes the mechanoenzymology of the cardiac myosin powerstroke.
Proc Natl Acad Sci U S A
; 114(10): E1796-E1804, 2017 03 07.
Artigo
Inglês
| MEDLINE | ID: mdl-28223517
10.
Direct real-time detection of the structural and biochemical events in the myosin power stroke.
Proc Natl Acad Sci U S A
; 112(46): 14272-7, 2015 Nov 17.
Artigo
Inglês
| MEDLINE | ID: mdl-26578772
11.
Direct measurements of the coordination of lever arm swing and the catalytic cycle in myosin V.
Proc Natl Acad Sci U S A
; 112(47): 14593-8, 2015 Nov 24.
Artigo
Inglês
| MEDLINE | ID: mdl-26553992
12.
The structural kinetics of switch-1 and the neck linker explain the functions of kinesin-1 and Eg5.
Proc Natl Acad Sci U S A
; 112(48): E6606-13, 2015 Dec 01.
Artigo
Inglês
| MEDLINE | ID: mdl-26627252
13.
Direct real-time detection of the actin-activated power stroke within the myosin catalytic domain.
Proc Natl Acad Sci U S A
; 110(18): 7211-6, 2013 Apr 30.
Artigo
Inglês
| MEDLINE | ID: mdl-23589853
14.
The Myosin SRX Comes into Focus.
Biophys J
; 119(6): 1041-1042, 2020 09 15.
Artigo
Inglês
| MEDLINE | ID: mdl-32853563
15.
Loop L5 assumes three distinct orientations during the ATPase cycle of the mitotic kinesin Eg5: a transient and time-resolved fluorescence study.
J Biol Chem
; 288(48): 34839-49, 2013 Nov 29.
Artigo
Inglês
| MEDLINE | ID: mdl-24145034
16.
Two operational modes of atomic force microscopy reveal similar mechanical properties for homologous regions of dystrophin and utrophin.
bioRxiv
; 2024 May 20.
Artigo
Inglês
| MEDLINE | ID: mdl-38826288
17.
Allosteric coupling asymmetry mediates paradoxical activation of BRAF by type II inhibitors.
Elife
; 132024 May 14.
Artigo
Inglês
| MEDLINE | ID: mdl-38742856
18.
Magnesium impacts myosin V motor activity by altering key conformational changes in the mechanochemical cycle.
Biochemistry
; 52(27): 4710-22, 2013 Jul 09.
Artigo
Inglês
| MEDLINE | ID: mdl-23725637
19.
Desmoglein 2 Functions as a Receptor for Fatty Acid Binding Protein 4 in Breast Cancer Epithelial Cells.
Mol Cancer Res
; 21(8): 836-848, 2023 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-37115197
20.
Allosteric coupling asymmetry mediates paradoxical activation of BRAF by type II inhibitors.
bioRxiv
; 2023 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37131649