Detalhe da pesquisa
1.
A rapid method for cross-species quantitation of apolipoproteins A1, B48 and B100 in plasma by ultra-performance liquid chromatography/tandem mass spectrometry.
Rapid Commun Mass Spectrom
; 26(2): 101-8, 2012 Jan 30.
Artigo
Inglês
| MEDLINE | ID: mdl-22173797
2.
Discovery of benzodihydroisofurans as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase inhibitors.
Bioorg Med Chem Lett
; 22(4): 1550-6, 2012 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22264488
3.
Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties.
J Med Chem
; 64(18): 13215-13258, 2021 09 23.
Artigo
Inglês
| MEDLINE | ID: mdl-34375108
4.
Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites.
Bioorg Med Chem Lett
; 20(15): 4359-63, 2010 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20615696
5.
AMP-activated protein kinase and nitric oxide regulate the glucose sensitivity of ventromedial hypothalamic glucose-inhibited neurons.
Am J Physiol Cell Physiol
; 297(3): C750-8, 2009 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-19570894
6.
Discovery and Pharmacology of a Novel Somatostatin Subtype 5 (SSTR5) Antagonist: Synergy with DPP-4 Inhibition.
ACS Med Chem Lett
; 9(11): 1082-1087, 2018 Nov 08.
Artigo
Inglês
| MEDLINE | ID: mdl-30429949
7.
Optimization of Preclinical Metabolism for Somatostatin Receptor Subtype 5-Selective Antagonists.
ACS Med Chem Lett
; 9(11): 1088-1093, 2018 Nov 08.
Artigo
Inglês
| MEDLINE | ID: mdl-30429950
8.
DGAT2 Inhibition Alters Aspects of Triglyceride Metabolism in Rodents but Not in Non-human Primates.
Cell Metab
; 27(6): 1236-1248.e6, 2018 Jun 05.
Artigo
Inglês
| MEDLINE | ID: mdl-29706567
9.
siRNA-mediated inhibition of SREBP cleavage-activating protein reduces dyslipidemia in spontaneously dysmetabolic rhesus monkeys.
Metabolism
; 71: 202-212, 2017 06.
Artigo
Inglês
| MEDLINE | ID: mdl-28521874
10.
Glucagon like receptor 1/ glucagon dual agonist acutely enhanced hepatic lipid clearance and suppressed de novo lipogenesis in mice.
PLoS One
; 12(10): e0186586, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-29065174
11.
Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors.
J Med Chem
; 60(9): 3594-3605, 2017 05 11.
Artigo
Inglês
| MEDLINE | ID: mdl-28252959
12.
Discovery of Novel Indoline Cholesterol Ester Transfer Protein Inhibitors (CETP) through a Structure-Guided Approach.
ACS Med Chem Lett
; 7(3): 261-5, 2016 Mar 10.
Artigo
Inglês
| MEDLINE | ID: mdl-26985312
13.
Potential mechanism of enhanced postprandial glucagon-like peptide-1 release following treatment with a diacylglycerol acyltransferase 1 inhibitor.
Pharmacol Res Perspect
; 3(6): e00193, 2015 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-27022467
14.
Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.
J Med Chem
; 53(8): 3330-48, 2010 Apr 22.
Artigo
Inglês
| MEDLINE | ID: mdl-20307063
15.
Fasting enhances the response of arcuate neuropeptide Y-glucose-inhibited neurons to decreased extracellular glucose.
Am J Physiol Cell Physiol
; 296(4): C746-56, 2009 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-19211911