Detalhe da pesquisa
1.
Orally bioavailable amine-linked macrocyclic inhibitors of factor XIa.
Bioorg Med Chem Lett
; 30(4): 126949, 2020 02 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31932224
2.
Discovery of a phenylpyrazole amide ROCK inhibitor as a tool molecule for in vivo studies.
Bioorg Med Chem Lett
; 30(21): 127495, 2020 11 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32798651
3.
Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability.
Bioorg Med Chem Lett
; 29(19): 126604, 2019 10 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31445854
4.
Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors.
Bioorg Med Chem Lett
; 28(6): 987-992, 2018 04 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29501396
5.
Macrocyclic factor XIa inhibitors.
Bioorg Med Chem Lett
; 27(17): 4056-4060, 2017 09 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28780160
6.
Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potency.
Bioorg Med Chem Lett
; 27(16): 3833-3839, 2017 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28687203
7.
Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group.
Bioorg Med Chem
; 24(10): 2257-72, 2016 05 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27073051
8.
Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties.
Bioorg Med Chem Lett
; 25(7): 1635-42, 2015 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25728130
9.
Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy.
J Med Chem
; 65(3): 1770-1785, 2022 02 10.
Artigo
Inglês
| MEDLINE | ID: mdl-34494428
10.
Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species.
J Med Chem
; 63(13): 7226-7242, 2020 07 09.
Artigo
Inglês
| MEDLINE | ID: mdl-32456431
11.
Potent, Orally Bioavailable, and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups.
J Med Chem
; 63(2): 784-803, 2020 01 23.
Artigo
Inglês
| MEDLINE | ID: mdl-31833761
12.
Crystal structures of MEK1 binary and ternary complexes with nucleotides and inhibitors.
Biochemistry
; 48(12): 2661-74, 2009 Mar 31.
Artigo
Inglês
| MEDLINE | ID: mdl-19161339
13.
Structure-Based Design of Macrocyclic Factor XIa Inhibitors: Discovery of the Macrocyclic Amide Linker.
J Med Chem
; 60(3): 1060-1075, 2017 02 09.
Artigo
Inglês
| MEDLINE | ID: mdl-28085275
14.
Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212).
J Med Chem
; 60(23): 9703-9723, 2017 12 14.
Artigo
Inglês
| MEDLINE | ID: mdl-29077405
15.
Crystal structure of microtubule affinity-regulating kinase 4 catalytic domain in complex with a pyrazolopyrimidine inhibitor.
Acta Crystallogr F Struct Biol Commun
; 72(Pt 2): 129-34, 2016 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-26841763
16.
Discovery of a Potent Parenterally Administered Factor XIa Inhibitor with Hydroxyquinolin-2(1H)-one as the P2' Moiety.
ACS Med Chem Lett
; 6(5): 590-5, 2015 May 14.
Artigo
Inglês
| MEDLINE | ID: mdl-26005539